A single-center study of treatment outcomes of pediatric basal ganglia germinoma in Taiwan

Yu Mei Kang, Shih Chieh Lin, Yi Yen Lee, Feng Chi Chang, Muh Lii Liang, Hsin Hung Chen, Tai Tong Wong, Yi Wei Chen

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Purpose: A basal ganglia (BG) germinoma is a rare tumor, and the optimal treatment remains unknown. We evaluated the clinical outcomes of treatment of BG germinoma in pediatric patients in Taiwan. Methods: We retrospectively reviewed the medical records of 34 children with BG germinoma who were treated with radiotherapy (RT) at Taipei Veterans General Hospital between 1989 and 2016. The median follow-up time is 8.3 years (1.8–25.2 years). Survival was analyzed using the Kaplan–Meier estimate. Univariate Cox proportional-hazards models were used to identify the potential risk factors. Results: Only four patients (11.8%) experienced recurrence and all successfully underwent salvage therapy. One patient (2.97%) died due to suspected radiotherapy (RT)-related sarcoma in the scalp. The 2-, 3-, and 5-year DFS rates were 91.2%, 88.2%, and 79.4%, respectively; the 2-, 3-, and 5-year OS rates were 97.1%, 94.1%, and 82.4%, respectively. Focal RT showed low DFS in the Kaplan–Meier survival curves (P =.028) compared with non-focal RT (whole ventricle, whole brain, or cranial spinal area). In the univariate Cox proportional-hazards model, there was a significant difference in DFS between focal and non-focal RT (P =.03). There is no difference in DFS and OS between BG germinoma patients and non-BG germinoma patients. Conclusions: We found an excellent DFS and OS in pediatric patients with BG germinoma treated with RT. Whole ventricle irradiation is recommended for good tumor control and low treatment-related toxicity. BG germinoma patients showed similar treatment results as germinoma patients in other common sites.

Original languageEnglish
Pages (from-to)1745-1753
Number of pages9
JournalChild's Nervous System
Issue number8
Publication statusPublished - Aug 1 2020
Externally publishedYes


  • Basal ganglia
  • Chemotherapy
  • Germinoma
  • Pediatric
  • Radiotherapy
  • Whole ventricular irradiation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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