Abstract
We made an effort to prepare effective cantharidinimides by heating the reactants 1 and 2a-j to 200°C with toluene and triethylamine to provide 10 N-thiazolyl- and N-thiadiazolylcantharidinimides 3a-j in high yields of 48-91%. All of the synthetic compounds were tested for their capability to suppress growth of the human hepatocellular carcinoma cell lines, SK-Hep-1 and Hep 3B. The results showed that compound 3f was the most potent, and it was more cytotoxic than cantharidin.
| Original language | English |
|---|---|
| Pages (from-to) | 266-272 |
| Number of pages | 7 |
| Journal | Bioorganic Chemistry |
| Volume | 28 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2000 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Cantharidin
- Cytotoxicity
- Human hepatocellular carcinoma cell
- N-thiadiazolylcantharidinimide
- N-thiazolylcantharidinimide
ASJC Scopus subject areas
- Drug Discovery
- Molecular Biology
- Biochemistry
- Organic Chemistry
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