TY - JOUR
T1 - A simple procedure for preparation of N-thiazolyl and N-thiadiazolylcantharidinimides and evaluation of their cytotoxicities against human hepatocellular carcinoma cells
AU - Pen-Yuan, Lin
AU - Sheng-Jie, Shi
AU - Hsien-Liang, Shu
AU - Hsue-Fen, Chen
AU - Chiung-Chang, Lin
AU - Pong-Chun, Liu
AU - Wang, Leng-Fang
PY - 2000
Y1 - 2000
N2 - We made an effort to prepare effective cantharidinimides by heating the reactants 1 and 2a-j to 200°C with toluene and triethylamine to provide 10 N-thiazolyl- and N-thiadiazolylcantharidinimides 3a-j in high yields of 48-91%. All of the synthetic compounds were tested for their capability to suppress growth of the human hepatocellular carcinoma cell lines, SK-Hep-1 and Hep 3B. The results showed that compound 3f was the most potent, and it was more cytotoxic than cantharidin.
AB - We made an effort to prepare effective cantharidinimides by heating the reactants 1 and 2a-j to 200°C with toluene and triethylamine to provide 10 N-thiazolyl- and N-thiadiazolylcantharidinimides 3a-j in high yields of 48-91%. All of the synthetic compounds were tested for their capability to suppress growth of the human hepatocellular carcinoma cell lines, SK-Hep-1 and Hep 3B. The results showed that compound 3f was the most potent, and it was more cytotoxic than cantharidin.
KW - Cantharidin
KW - Cytotoxicity
KW - Human hepatocellular carcinoma cell
KW - N-thiadiazolylcantharidinimide
KW - N-thiazolylcantharidinimide
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U2 - 10.1006/bioo.2000.1178
DO - 10.1006/bioo.2000.1178
M3 - Article
AN - SCOPUS:0034520232
SN - 0045-2068
VL - 28
SP - 266
EP - 272
JO - Bioorganic Chemistry
JF - Bioorganic Chemistry
IS - 5
ER -