A sequence-based prediction of Kruppel-like factors proteins using XGBoost and optimized features

Nguyen Quoc Khanh Le, Duyen Thi Do, Trinh Trung Duong Nguyen, Quynh Anh Le

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


Krüppel-like factors (KLF) refer to a group of conserved zinc finger-containing transcription factors that are involved in various physiological and biological processes, including cell proliferation, differentiation, development, and apoptosis. Some bioinformatics methods such as sequence similarity searches, multiple sequence alignment, phylogenetic reconstruction, and gene synteny analysis have also been proposed to broaden our knowledge of KLF proteins. In this study, we proposed a novel computational approach by using machine learning on features calculated from primary sequences. To detail, our XGBoost-based model is efficient in identifying KLF proteins, with accuracy of 96.4% and MCC of 0.704. It also holds a promising performance when testing our model on an independent dataset. Therefore, our model could serve as an useful tool to identify new KLF proteins and provide necessary information for biologists and researchers in KLF proteins. Our machine learning source codes as well as datasets are freely available at https://github.com/khanhlee/KLF-XGB.

Original languageEnglish
Article number145643
Publication statusPublished - Jun 30 2021


  • eXtreme Gradient Boosting
  • Feature selection
  • Kruppel-like factor
  • Protein sequence
  • SMOTE imbalance
  • Zinc finger

ASJC Scopus subject areas

  • Genetics


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