A prospective randomized study of brain tissue oxygen pressure-guided management in moderate and severe traumatic brain injury patients

Chien Min Lin; Ming Chin Lin; Sheng Jean Huang; Cheng Kuei Chang; Dan Ping Chao; Tai Ngar Lui; Hsin I. Ma; Ming Ying Liu; Wen Yuh Chung; Yang Hsin Shih; Shin Han Tsai; Hung Yi Chiou; Mau Roung Lin; Sen Li Jen; Li Wei; Chung-Che Wu; En Yuan Lin; Kuo Hsing Liao; Yung Hsiao Chiang; Wen Ta Chiu; Jia Wei Lin

doi:10.1155/2015/529580

A prospective randomized study of brain tissue oxygen pressure-guided management in moderate and severe traumatic brain injury patients

Chien Min Lin, Ming Chin Lin, Sheng Jean Huang, Cheng Kuei Chang, Dan Ping Chao, Tai Ngar Lui, Hsin I. Ma, Ming Ying Liu, Wen Yuh Chung, Yang Hsin Shih, Shin Han Tsai, Hung Yi Chiou, Mau Roung Lin, Sen Li Jen, Li Wei, Chung-Che Wu, En Yuan Lin, Kuo Hsing Liao, Yung Hsiao Chiang, Wen Ta ChiuJia Wei Lin

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Abstract

The purpose of this study was to compare the effect of PbtOguided therapy with traditional intracranial pressure- (ICP-) guided treatment on the management of cerebral variables, therapeutic interventions, survival rates, and neurological outcomes of moderate and severe traumatic brain injury (TBI) patients. From 2009 to 2010, TBI patients with a Glasgow coma scale 20 mmHg), and 27 patients were treated with ICP-guided therapy (ICP <20 mmHg and CPP > 60 mmHg) in the neurosurgical intensive care unit (NICU); demographic characteristics were similar across groups. The survival rate in the PbtOguided group was also significantly increased at 3 and 6 months after injury. Moreover, there was a significant correlation between the PbtOsignal and Glasgow outcome scale-extended in patients from 1 to 6 months after injury. This finding demonstrates that therapy directed by PbtOmonitoring is valuable for the treatment of patients with moderate and severe TBI and that increasing PaOto 150 mmHg may be efficacious for preventing cerebral hypoxic events after brain trauma.

Original language	English
Article number	529580
Journal	BioMed Research International
Volume	2015
DOIs	https://doi.org/10.1155/2015/529580
Publication status	Published - 2015

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology
General Immunology and Microbiology

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Lin, C. M., Lin, M. C., Huang, S. J., Chang, C. K., Chao, D. P., Lui, T. N., Ma, H. I., Liu, M. Y., Chung, W. Y., Shih, Y. H., Tsai, S. H., Chiou, H. Y., Lin, M. R., Jen, S. L., Wei, L., Wu, C.-C., Lin, E. Y., Liao, K. H., Chiang, Y. H., ... Lin, J. W. (2015). A prospective randomized study of brain tissue oxygen pressure-guided management in moderate and severe traumatic brain injury patients. BioMed Research International, 2015, Article 529580. https://doi.org/10.1155/2015/529580

Lin, CM , Lin, MC, Huang, SJ, Chang, CK, Chao, DP, Lui, TN, Ma, HI, Liu, MY, Chung, WY, Shih, YH, Tsai, SH , Chiou, HY , Lin, MR, Jen, SL, Wei, L , Wu, C-C, Lin, EY, Liao, KH , Chiang, YH , Chiu, WT & Lin, JW 2015, 'A prospective randomized study of brain tissue oxygen pressure-guided management in moderate and severe traumatic brain injury patients', BioMed Research International, vol. 2015, 529580. https://doi.org/10.1155/2015/529580

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title = "A prospective randomized study of brain tissue oxygen pressure-guided management in moderate and severe traumatic brain injury patients",

abstract = "The purpose of this study was to compare the effect of PbtOguided therapy with traditional intracranial pressure- (ICP-) guided treatment on the management of cerebral variables, therapeutic interventions, survival rates, and neurological outcomes of moderate and severe traumatic brain injury (TBI) patients. From 2009 to 2010, TBI patients with a Glasgow coma scale 20 mmHg), and 27 patients were treated with ICP-guided therapy (ICP <20 mmHg and CPP > 60 mmHg) in the neurosurgical intensive care unit (NICU); demographic characteristics were similar across groups. The survival rate in the PbtOguided group was also significantly increased at 3 and 6 months after injury. Moreover, there was a significant correlation between the PbtOsignal and Glasgow outcome scale-extended in patients from 1 to 6 months after injury. This finding demonstrates that therapy directed by PbtOmonitoring is valuable for the treatment of patients with moderate and severe TBI and that increasing PaOto 150 mmHg may be efficacious for preventing cerebral hypoxic events after brain trauma.",

author = "Lin, {Chien Min} and Lin, {Ming Chin} and Huang, {Sheng Jean} and Chang, {Cheng Kuei} and Chao, {Dan Ping} and Lui, {Tai Ngar} and Ma, {Hsin I.} and Liu, {Ming Ying} and Chung, {Wen Yuh} and Shih, {Yang Hsin} and Tsai, {Shin Han} and Chiou, {Hung Yi} and Lin, {Mau Roung} and Jen, {Sen Li} and Li Wei and Chung-Che Wu and Lin, {En Yuan} and Liao, {Kuo Hsing} and Chiang, {Yung Hsiao} and Chiu, {Wen Ta} and Lin, {Jia Wei}",

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year = "2015",

doi = "10.1155/2015/529580",

language = "English",

volume = "2015",

journal = "BioMed Research International",

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AU - Lin, Chien Min

AU - Lin, Ming Chin

AU - Huang, Sheng Jean

AU - Chang, Cheng Kuei

AU - Chao, Dan Ping

AU - Lui, Tai Ngar

AU - Ma, Hsin I.

AU - Liu, Ming Ying

AU - Chung, Wen Yuh

AU - Shih, Yang Hsin

AU - Tsai, Shin Han

AU - Chiou, Hung Yi

AU - Lin, Mau Roung

AU - Jen, Sen Li

AU - Wei, Li

AU - Wu, Chung-Che

AU - Lin, En Yuan

AU - Liao, Kuo Hsing

AU - Chiang, Yung Hsiao

AU - Chiu, Wen Ta

AU - Lin, Jia Wei

PY - 2015

Y1 - 2015

N2 - The purpose of this study was to compare the effect of PbtOguided therapy with traditional intracranial pressure- (ICP-) guided treatment on the management of cerebral variables, therapeutic interventions, survival rates, and neurological outcomes of moderate and severe traumatic brain injury (TBI) patients. From 2009 to 2010, TBI patients with a Glasgow coma scale 20 mmHg), and 27 patients were treated with ICP-guided therapy (ICP <20 mmHg and CPP > 60 mmHg) in the neurosurgical intensive care unit (NICU); demographic characteristics were similar across groups. The survival rate in the PbtOguided group was also significantly increased at 3 and 6 months after injury. Moreover, there was a significant correlation between the PbtOsignal and Glasgow outcome scale-extended in patients from 1 to 6 months after injury. This finding demonstrates that therapy directed by PbtOmonitoring is valuable for the treatment of patients with moderate and severe TBI and that increasing PaOto 150 mmHg may be efficacious for preventing cerebral hypoxic events after brain trauma.

AB - The purpose of this study was to compare the effect of PbtOguided therapy with traditional intracranial pressure- (ICP-) guided treatment on the management of cerebral variables, therapeutic interventions, survival rates, and neurological outcomes of moderate and severe traumatic brain injury (TBI) patients. From 2009 to 2010, TBI patients with a Glasgow coma scale 20 mmHg), and 27 patients were treated with ICP-guided therapy (ICP <20 mmHg and CPP > 60 mmHg) in the neurosurgical intensive care unit (NICU); demographic characteristics were similar across groups. The survival rate in the PbtOguided group was also significantly increased at 3 and 6 months after injury. Moreover, there was a significant correlation between the PbtOsignal and Glasgow outcome scale-extended in patients from 1 to 6 months after injury. This finding demonstrates that therapy directed by PbtOmonitoring is valuable for the treatment of patients with moderate and severe TBI and that increasing PaOto 150 mmHg may be efficacious for preventing cerebral hypoxic events after brain trauma.

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A prospective randomized study of brain tissue oxygen pressure-guided management in moderate and severe traumatic brain injury patients

Abstract

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