A portable micro gas chromatography system for lung cancer associated volatile organic compound detection

Te Hsuen Tzeng; Chun Yen Kuo; San Yuan Wang; Po Kai Huang; Yen Ming Huang; Wei Che Hsieh; Yu Jie Huang; Po Hung Kuo; Shih An Yu; Si Chen Lee; Yufeng Jane Tseng; Wei Cheng Tian; Shey Shi Lu

doi:10.1109/JSSC.2015.2489839

A portable micro gas chromatography system for lung cancer associated volatile organic compound detection

Te Hsuen Tzeng, Chun Yen Kuo, San Yuan Wang, Po Kai Huang, Yen Ming Huang, Wei Che Hsieh, Yu Jie Huang, Po Hung Kuo, Shih An Yu, Si Chen Lee, Yufeng Jane Tseng, Wei Cheng Tian, Shey Shi Lu

Research output: Contribution to journal › Article › peer-review

72 Citations (Scopus)

Abstract

With the help of micro-electromechanical systems (MEMS) and complementary metal-oxide-semiconductor (CMOS) technology, a portable micro gas chromatography (μGC) system for lung cancer associated volatile organic compounds (VOCs) detection is realized for the first time. The system is composed of an MEMS preconcentrator, an MEMS separation column, and a CMOS system-on-chip (SoC). The preconcentrator provides a concentration ratio of 2170. The separation column can separate more than seven types of lung cancer associated VOCs. The SoC is fabricated by a TSMC 0.35 μm 2P4M process including the CMOS VOCs detector, sensor calibration circuit, low-noise chopper instrumentation amplifier (IA), 10 bit analog to digital converter, and the microcontrol unit (MCU). Experimental results show that the system is able to detect seven types of lung cancer associated VOCs (acetone, 2-butanone, benzene, heptane, toluene, m-xylene, 1,3,5-trimethylbenzene). The concentration linearity is R² = 0.985 and the detection sensitivity is up to 15 ppb with 1,3,5-trimethylbenzene.

Original language	English
Article number	7314865
Pages (from-to)	259-272
Number of pages	14
Journal	IEEE Journal of Solid-State Circuits
Volume	51
Issue number	1
DOIs	https://doi.org/10.1109/JSSC.2015.2489839
Publication status	Published - Jan 1 2016
Externally published	Yes

Keywords

Biomedical
Calibration
Complementary metal-oxide-semiconductor-micro-electromechanical system (CMOS-MEMS)
Continuous wavelet transform (CWT)
Deconvolution
Micro gas chromatography (μGC )
System-on-chip (SoC)
Volatile organic compound (VOCS)

ASJC Scopus subject areas

Electrical and Electronic Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/JSSC.2015.2489839

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Tzeng, T. H., Kuo, C. Y., Wang, S. Y., Huang, P. K., Huang, Y. M., Hsieh, W. C., Huang, Y. J., Kuo, P. H., Yu, S. A., Lee, S. C., Tseng, Y. J., Tian, W. C., & Lu, S. S. (2016). A portable micro gas chromatography system for lung cancer associated volatile organic compound detection. IEEE Journal of Solid-State Circuits, 51(1), 259-272. Article 7314865. https://doi.org/10.1109/JSSC.2015.2489839

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abstract = "With the help of micro-electromechanical systems (MEMS) and complementary metal-oxide-semiconductor (CMOS) technology, a portable micro gas chromatography (μGC) system for lung cancer associated volatile organic compounds (VOCs) detection is realized for the first time. The system is composed of an MEMS preconcentrator, an MEMS separation column, and a CMOS system-on-chip (SoC). The preconcentrator provides a concentration ratio of 2170. The separation column can separate more than seven types of lung cancer associated VOCs. The SoC is fabricated by a TSMC 0.35 μm 2P4M process including the CMOS VOCs detector, sensor calibration circuit, low-noise chopper instrumentation amplifier (IA), 10 bit analog to digital converter, and the microcontrol unit (MCU). Experimental results show that the system is able to detect seven types of lung cancer associated VOCs (acetone, 2-butanone, benzene, heptane, toluene, m-xylene, 1,3,5-trimethylbenzene). The concentration linearity is R2 = 0.985 and the detection sensitivity is up to 15 ppb with 1,3,5-trimethylbenzene.",

keywords = "Biomedical, Calibration, Complementary metal-oxide-semiconductor-micro-electromechanical system (CMOS-MEMS), Continuous wavelet transform (CWT), Deconvolution, Micro gas chromatography (μGC ), System-on-chip (SoC), Volatile organic compound (VOCS)",

author = "Tzeng, {Te Hsuen} and Kuo, {Chun Yen} and Wang, {San Yuan} and Huang, {Po Kai} and Huang, {Yen Ming} and Hsieh, {Wei Che} and Huang, {Yu Jie} and Kuo, {Po Hung} and Yu, {Shih An} and Lee, {Si Chen} and Tseng, {Yufeng Jane} and Tian, {Wei Cheng} and Lu, {Shey Shi}",

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year = "2016",

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doi = "10.1109/JSSC.2015.2489839",

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T1 - A portable micro gas chromatography system for lung cancer associated volatile organic compound detection

AU - Tzeng, Te Hsuen

AU - Kuo, Chun Yen

AU - Wang, San Yuan

AU - Huang, Po Kai

AU - Huang, Yen Ming

AU - Hsieh, Wei Che

AU - Huang, Yu Jie

AU - Kuo, Po Hung

AU - Yu, Shih An

AU - Lee, Si Chen

AU - Tseng, Yufeng Jane

AU - Tian, Wei Cheng

AU - Lu, Shey Shi

PY - 2016/1/1

Y1 - 2016/1/1

N2 - With the help of micro-electromechanical systems (MEMS) and complementary metal-oxide-semiconductor (CMOS) technology, a portable micro gas chromatography (μGC) system for lung cancer associated volatile organic compounds (VOCs) detection is realized for the first time. The system is composed of an MEMS preconcentrator, an MEMS separation column, and a CMOS system-on-chip (SoC). The preconcentrator provides a concentration ratio of 2170. The separation column can separate more than seven types of lung cancer associated VOCs. The SoC is fabricated by a TSMC 0.35 μm 2P4M process including the CMOS VOCs detector, sensor calibration circuit, low-noise chopper instrumentation amplifier (IA), 10 bit analog to digital converter, and the microcontrol unit (MCU). Experimental results show that the system is able to detect seven types of lung cancer associated VOCs (acetone, 2-butanone, benzene, heptane, toluene, m-xylene, 1,3,5-trimethylbenzene). The concentration linearity is R2 = 0.985 and the detection sensitivity is up to 15 ppb with 1,3,5-trimethylbenzene.

AB - With the help of micro-electromechanical systems (MEMS) and complementary metal-oxide-semiconductor (CMOS) technology, a portable micro gas chromatography (μGC) system for lung cancer associated volatile organic compounds (VOCs) detection is realized for the first time. The system is composed of an MEMS preconcentrator, an MEMS separation column, and a CMOS system-on-chip (SoC). The preconcentrator provides a concentration ratio of 2170. The separation column can separate more than seven types of lung cancer associated VOCs. The SoC is fabricated by a TSMC 0.35 μm 2P4M process including the CMOS VOCs detector, sensor calibration circuit, low-noise chopper instrumentation amplifier (IA), 10 bit analog to digital converter, and the microcontrol unit (MCU). Experimental results show that the system is able to detect seven types of lung cancer associated VOCs (acetone, 2-butanone, benzene, heptane, toluene, m-xylene, 1,3,5-trimethylbenzene). The concentration linearity is R2 = 0.985 and the detection sensitivity is up to 15 ppb with 1,3,5-trimethylbenzene.

KW - Biomedical

KW - Calibration

KW - Complementary metal-oxide-semiconductor-micro-electromechanical system (CMOS-MEMS)

KW - Continuous wavelet transform (CWT)

KW - Deconvolution

KW - Micro gas chromatography (μGC )

KW - System-on-chip (SoC)

KW - Volatile organic compound (VOCS)

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M1 - 7314865

ER -

A portable micro gas chromatography system for lung cancer associated volatile organic compound detection

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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