TY - JOUR
T1 - A population-based cohort study suggests an increased risk of multiple sclerosis incidence in patients with type 2 diabetes mellitus
AU - Hou, Wen Hsuan
AU - Li, Chung Yi
AU - Chang, Hsin-Hui
AU - Sun, Yu
AU - Tsai, Chiang Chin
PY - 2017
Y1 - 2017
N2 - Background: To prospectively investigate the incidence and relative risks of multiple sclerosis (MS) in patients with type 2 diabetes (T2DM). Materials and methods: Patients with T2DM (n = 614,623) and age- and sex-matched controls (n = 614,021) were followed from 2000 to 2008 to identify cases of newly diagnosed MS (ICD-9-CM: 340). The person-year approach with Poisson assumption was used to evaluate the incidence density. We estimated the covariate-adjusted hazard ratio (HR) of MS incidence in relation to T2DM diabetes using a multiple Cox proportional hazard regression model. Results: Over 9 years of follow-up, 175 T2DM patients were newly diagnosed with MS, and 114 matched controls had the same first-ever diagnosis, representing a covariate-adjusted HR of 1.44 (95% confidence interval [CI], 1.08-1.94). The sex-specific adjusted HR for both men and women with T2DM was also elevated at 1.34 (95% CI, 0.81-2.23) and 1.51 (95% CI, 1.05-2.19), respectively. Women aged <50 years had the greatest risk of MS (HR 2.16; 95% CI, 1.02-4.59). Conclusion: This study demonstrated a moderate but significant association of T2DM with MS incidence, and the association was not confounded by socio-demographic characteristics or certain MS-related comorbidities.
AB - Background: To prospectively investigate the incidence and relative risks of multiple sclerosis (MS) in patients with type 2 diabetes (T2DM). Materials and methods: Patients with T2DM (n = 614,623) and age- and sex-matched controls (n = 614,021) were followed from 2000 to 2008 to identify cases of newly diagnosed MS (ICD-9-CM: 340). The person-year approach with Poisson assumption was used to evaluate the incidence density. We estimated the covariate-adjusted hazard ratio (HR) of MS incidence in relation to T2DM diabetes using a multiple Cox proportional hazard regression model. Results: Over 9 years of follow-up, 175 T2DM patients were newly diagnosed with MS, and 114 matched controls had the same first-ever diagnosis, representing a covariate-adjusted HR of 1.44 (95% confidence interval [CI], 1.08-1.94). The sex-specific adjusted HR for both men and women with T2DM was also elevated at 1.34 (95% CI, 0.81-2.23) and 1.51 (95% CI, 1.05-2.19), respectively. Women aged <50 years had the greatest risk of MS (HR 2.16; 95% CI, 1.02-4.59). Conclusion: This study demonstrated a moderate but significant association of T2DM with MS incidence, and the association was not confounded by socio-demographic characteristics or certain MS-related comorbidities.
KW - Cohort studies
KW - Cox proportional hazard model
KW - Diabetes mellitus
KW - Multiple sclerosis
UR - http://www.scopus.com/inward/record.url?scp=85019650900&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019650900&partnerID=8YFLogxK
U2 - 10.1016/j.je.2016.06.006
DO - 10.1016/j.je.2016.06.006
M3 - Article
C2 - 28142047
AN - SCOPUS:85019650900
SN - 0917-5040
VL - 27
SP - 235
EP - 241
JO - Journal of Epidemiology
JF - Journal of Epidemiology
IS - 5
ER -