A phase II study of lapatinib in patients with advanced biliary tree and hepatocellular cancer

Ramesh K. Ramanathan; Chandra P. Belani; Deepti A. Singh; Michael Tanaka; Heinz Josef Lenz; Yun Yen; Hedy L. Kindler; Syma Iqbal; Jeff Longmate; Philip C. MacK; Georg Lurje; Regina Gandour-Edwards; Janet Dancey; David R. Gandara

doi:10.1007/s00280-009-0927-7

A phase II study of lapatinib in patients with advanced biliary tree and hepatocellular cancer

Ramesh K. Ramanathan, Chandra P. Belani, Deepti A. Singh, Michael Tanaka, Heinz Josef Lenz, Yun Yen, Hedy L. Kindler, Syma Iqbal, Jeff Longmate, Philip C. MacK, Georg Lurje, Regina Gandour-Edwards, Janet Dancey, David R. Gandara

Research output: Contribution to journal › Article › peer-review

267 Citations (Scopus)

Abstract

Purpose: To evaluate the response to lapatinib, an inhibitor of epidermal growth factor receptors 1 and 2, in patients with advanced bilary tree cancer (BTC) and hepatocellular cancer (HCC). Methods: Lapatinib was dosed at 1,500 mg/day orally continuously. Results: Fifty-seven patients were accrued (BTC 17, HCC 40). Therapy was well tolerated. The response in BTC was 0% and in HCC was 5%. The progression free survival (PFS) for BTC and HCC patients was 1.8 (95% CI: 1.7-5.2) months and 2.3 (95% CI: 1.7-5.6) months. The median survival for BTC and HCC patients was 5.2 (95% CI 3.3-∞) months and 6.2 (95% CI: 5.1-∞) months. EGFR genotyping indicated HCC patients with <20 repeats have the lowest PFS. The occurrence of any skin rash significantly prolonged PFS and survival. Conclusions: Lapatinib was well-tolerated. There was evidence of activity in HCC, but therapy with lapatinib did not meet the predefined efficacy rate.

Original language	English
Pages (from-to)	777-783
Number of pages	7
Journal	Cancer Chemotherapy and Pharmacology
Volume	64
Issue number	4
DOIs	https://doi.org/10.1007/s00280-009-0927-7
Publication status	Published - Sept 2009
Externally published	Yes

Keywords

Biliary tree cancer
Hepatocellular cancer
Lapatinib
Phase II study

ASJC Scopus subject areas

Oncology
Toxicology
Pharmacology
Cancer Research
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00280-009-0927-7

Cite this

Ramanathan, R. K., Belani, C. P., Singh, D. A., Tanaka, M., Lenz, H. J., Yen, Y., Kindler, H. L., Iqbal, S., Longmate, J., MacK, P. C., Lurje, G., Gandour-Edwards, R., Dancey, J., & Gandara, D. R. (2009). A phase II study of lapatinib in patients with advanced biliary tree and hepatocellular cancer. Cancer Chemotherapy and Pharmacology, 64(4), 777-783. https://doi.org/10.1007/s00280-009-0927-7

Ramanathan, RK, Belani, CP, Singh, DA, Tanaka, M, Lenz, HJ, Yen, Y, Kindler, HL, Iqbal, S, Longmate, J, MacK, PC, Lurje, G, Gandour-Edwards, R, Dancey, J & Gandara, DR 2009, 'A phase II study of lapatinib in patients with advanced biliary tree and hepatocellular cancer', Cancer Chemotherapy and Pharmacology, vol. 64, no. 4, pp. 777-783. https://doi.org/10.1007/s00280-009-0927-7

@article{f7cfa1d161a64768a6365834f5b43e70,

title = "A phase II study of lapatinib in patients with advanced biliary tree and hepatocellular cancer",

abstract = "Purpose: To evaluate the response to lapatinib, an inhibitor of epidermal growth factor receptors 1 and 2, in patients with advanced bilary tree cancer (BTC) and hepatocellular cancer (HCC). Methods: Lapatinib was dosed at 1,500 mg/day orally continuously. Results: Fifty-seven patients were accrued (BTC 17, HCC 40). Therapy was well tolerated. The response in BTC was 0% and in HCC was 5%. The progression free survival (PFS) for BTC and HCC patients was 1.8 (95% CI: 1.7-5.2) months and 2.3 (95% CI: 1.7-5.6) months. The median survival for BTC and HCC patients was 5.2 (95% CI 3.3-∞) months and 6.2 (95% CI: 5.1-∞) months. EGFR genotyping indicated HCC patients with <20 repeats have the lowest PFS. The occurrence of any skin rash significantly prolonged PFS and survival. Conclusions: Lapatinib was well-tolerated. There was evidence of activity in HCC, but therapy with lapatinib did not meet the predefined efficacy rate.",

keywords = "Biliary tree cancer, Hepatocellular cancer, Lapatinib, Phase II study",

author = "Ramanathan, {Ramesh K.} and Belani, {Chandra P.} and Singh, {Deepti A.} and Michael Tanaka and Lenz, {Heinz Josef} and Yun Yen and Kindler, {Hedy L.} and Syma Iqbal and Jeff Longmate and MacK, {Philip C.} and Georg Lurje and Regina Gandour-Edwards and Janet Dancey and Gandara, {David R.}",

year = "2009",

month = sep,

doi = "10.1007/s00280-009-0927-7",

language = "English",

volume = "64",

pages = "777--783",

journal = "Cancer Chemotherapy and Pharmacology",

issn = "0344-5704",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "4",

}

TY - JOUR

T1 - A phase II study of lapatinib in patients with advanced biliary tree and hepatocellular cancer

AU - Ramanathan, Ramesh K.

AU - Belani, Chandra P.

AU - Singh, Deepti A.

AU - Tanaka, Michael

AU - Lenz, Heinz Josef

AU - Yen, Yun

AU - Kindler, Hedy L.

AU - Iqbal, Syma

AU - Longmate, Jeff

AU - MacK, Philip C.

AU - Lurje, Georg

AU - Gandour-Edwards, Regina

AU - Dancey, Janet

AU - Gandara, David R.

PY - 2009/9

Y1 - 2009/9

N2 - Purpose: To evaluate the response to lapatinib, an inhibitor of epidermal growth factor receptors 1 and 2, in patients with advanced bilary tree cancer (BTC) and hepatocellular cancer (HCC). Methods: Lapatinib was dosed at 1,500 mg/day orally continuously. Results: Fifty-seven patients were accrued (BTC 17, HCC 40). Therapy was well tolerated. The response in BTC was 0% and in HCC was 5%. The progression free survival (PFS) for BTC and HCC patients was 1.8 (95% CI: 1.7-5.2) months and 2.3 (95% CI: 1.7-5.6) months. The median survival for BTC and HCC patients was 5.2 (95% CI 3.3-∞) months and 6.2 (95% CI: 5.1-∞) months. EGFR genotyping indicated HCC patients with <20 repeats have the lowest PFS. The occurrence of any skin rash significantly prolonged PFS and survival. Conclusions: Lapatinib was well-tolerated. There was evidence of activity in HCC, but therapy with lapatinib did not meet the predefined efficacy rate.

AB - Purpose: To evaluate the response to lapatinib, an inhibitor of epidermal growth factor receptors 1 and 2, in patients with advanced bilary tree cancer (BTC) and hepatocellular cancer (HCC). Methods: Lapatinib was dosed at 1,500 mg/day orally continuously. Results: Fifty-seven patients were accrued (BTC 17, HCC 40). Therapy was well tolerated. The response in BTC was 0% and in HCC was 5%. The progression free survival (PFS) for BTC and HCC patients was 1.8 (95% CI: 1.7-5.2) months and 2.3 (95% CI: 1.7-5.6) months. The median survival for BTC and HCC patients was 5.2 (95% CI 3.3-∞) months and 6.2 (95% CI: 5.1-∞) months. EGFR genotyping indicated HCC patients with <20 repeats have the lowest PFS. The occurrence of any skin rash significantly prolonged PFS and survival. Conclusions: Lapatinib was well-tolerated. There was evidence of activity in HCC, but therapy with lapatinib did not meet the predefined efficacy rate.

KW - Biliary tree cancer

KW - Hepatocellular cancer

KW - Lapatinib

KW - Phase II study

UR - http://www.scopus.com/inward/record.url?scp=68149164263&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68149164263&partnerID=8YFLogxK

U2 - 10.1007/s00280-009-0927-7

DO - 10.1007/s00280-009-0927-7

M3 - Article

C2 - 19169683

AN - SCOPUS:68149164263

SN - 0344-5704

VL - 64

SP - 777

EP - 783

JO - Cancer Chemotherapy and Pharmacology

JF - Cancer Chemotherapy and Pharmacology

IS - 4

ER -

A phase II study of lapatinib in patients with advanced biliary tree and hepatocellular cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this