Abstract
A model of intima thickening proposed by Friedman and his coworkers is incorporated in our computer code to simulate the growth of intima under shear. The computer code is based on a finite volume method in a boundary-fitted coordinate system. It is found that the model yields an evenly-distributed thickening over a straight, smooth vessel wall. However, in a stenosed or a curved artery, thicker intima can be formed in preferential regions due to unevenly-distributed wall shear stresses. The results clearly demonstrate the correlations among the geometry, wall shear rate and the plaque localization in arteries. The model is applied to a straight artery with a stenosis of sinus, a smooth curved artery and a stenosed curved artery. The effects of stenosis/sinus and lumen curvature on the flows and the intimal thickening are studied. The simulation provides a numerical visualization of the intimal thickening in a dynamic way.
| Original language | English |
|---|---|
| Pages (from-to) | 337-351 |
| Number of pages | 15 |
| Journal | Biorheology |
| Volume | 29 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - Jan 1 1992 |
| Externally published | Yes |
ASJC Scopus subject areas
- Physiology
- Physiology (medical)