Abstract
The purpose of this study was to prepare resorbable α-calcium sulfate hemihydrate/amorphous calcium phosphate (α-CSH/ACP) bone substitute with a resorption period of 3-6 months specifically designed for dental implantation surgery. A one-pot process was used to manufacture α-CSH and ACP. Granular particles of α-CSH/ACP (60/40) with diameters of 420-840 μm were prepared. In dissolution test, both α-CSH/ACP (60/40) and CSD displayed rapid dissolution in the first 20 days, followed by a remarkably slow dissolution rate to reach weight retention plateaus of around 13.5%±0.7% and 40.5%±1.4% at 90 days, respectively. The in vivo study showed no adverse effects as a consequence of any of the implanted materials. After 3 weeks, the defects treated with α-CSH/ACP (60/40) showed more new bone formation (21.1%) than the empty control (13.6%) (p
Original language | English |
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Pages (from-to) | 440-446 |
Number of pages | 7 |
Journal | Materials Science and Engineering C |
Volume | 32 |
Issue number | 3 |
DOIs | |
Publication status | Published - Apr 1 2012 |
Keywords
- Amorphous calcium phosphate
- Bone graft substitute
- Dental implant surgery
- Resorption rate
- α-calcium sulfate hemihydrate
ASJC Scopus subject areas
- Condensed Matter Physics
- Mechanics of Materials
- Mechanical Engineering
- General Materials Science