A new sterol from the Formosan soft coral Lobophytum durum

Chia Ling Hung, Li Chieh Huang, Kun Yauh Shih, Kuei Hung Lai, Bo Rong Peng, Tsong Long Hwang, Su Ying Chien, Chia Ying Li, Hsu Ming Chung

Research output: Contribution to journalArticlepeer-review


Chromatographic investigation on the ethyl acetate extract of the soft coral Lobophytum durum collected from the waters of Guishan Island in northeast Taiwan resulted in the isolation of three sterols 1–3, including one new sterol, 3β-hydroxy-25-methylene-5-cholesten-7-one (1), and two previously reported sterols, 7-oxogorgosterol (2), and (24R)-ergostane-3β,5α,6β,25-tetraol 25-monoacetate (3). The structures of sterols 1–3 were determined by extensive spectroscopic data analysis and by comparison with literatures. Additionally, the 24R-configuration of sterol 3 was identified by a single-crystal X-ray diffraction analysis and 13C chemical shifts for first time. The anti-inflammatory activities of sterols 1–3 were evaluated by examining their inhibitory effects on the generation of superoxide anions and the release of elastase against activated human neutrophils.

Original languageEnglish
Article number136790
JournalJournal of Molecular Structure
Publication statusPublished - Jan 15 2024


  • Anti-inflammatory
  • Lobophytum durum
  • Soft coral
  • Sterol
  • X-ray

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Inorganic Chemistry


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