A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata

Zong-Huei Li; Ching Kuo Lee; Wan Lin Tsou; Sheng Yung Liu; Mao Tien Kuo; Wu Che Wen

doi:10.1055/s-2007-990232

A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata

Zong-Huei Li, Ching Kuo Lee, Wan Lin Tsou, Sheng Yung Liu, Mao Tien Kuo, Wu Che Wen

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

Antroquinonol (1), an ubiquinone derivative, was isolated from the solid-state fermented mycelium of Antrodia camphorata (Polyporaceae, Aphyllophorales), a parasitic fungus indigenous to Taiwan. The structure of compound 1 was elucidated by the analysis of their spectroscopic data. Its cytotoxic activities were evaluated against MCF-7, MDA-MB-231 (human breast carcinoma), Hep3B, HepG2 (human liver carcinoma) and DU-145, LNCaP (human prostate carcinoma) cell lines, and the IC₅₀ values ranged from 0.13 ± 0.02 to 6.09 ± 0.07 μM.

Original language	English
Pages (from-to)	1412-1415
Number of pages	4
Journal	Planta Medica
Volume	73
Issue number	13
DOIs	https://doi.org/10.1055/s-2007-990232
Publication status	Published - Oct 2007

ASJC Scopus subject areas

Plant Science
Drug Discovery
Organic Chemistry
Pharmacology

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title = "A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata",

abstract = "Antroquinonol (1), an ubiquinone derivative, was isolated from the solid-state fermented mycelium of Antrodia camphorata (Polyporaceae, Aphyllophorales), a parasitic fungus indigenous to Taiwan. The structure of compound 1 was elucidated by the analysis of their spectroscopic data. Its cytotoxic activities were evaluated against MCF-7, MDA-MB-231 (human breast carcinoma), Hep3B, HepG2 (human liver carcinoma) and DU-145, LNCaP (human prostate carcinoma) cell lines, and the IC50 values ranged from 0.13 ± 0.02 to 6.09 ± 0.07 μM.",

author = "Zong-Huei Li and Lee, {Ching Kuo} and Tsou, {Wan Lin} and Liu, {Sheng Yung} and Kuo, {Mao Tien} and Wen, {Wu Che}",

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AU - Li, Zong-Huei

AU - Lee, Ching Kuo

AU - Tsou, Wan Lin

AU - Liu, Sheng Yung

AU - Kuo, Mao Tien

AU - Wen, Wu Che

PY - 2007/10

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AB - Antroquinonol (1), an ubiquinone derivative, was isolated from the solid-state fermented mycelium of Antrodia camphorata (Polyporaceae, Aphyllophorales), a parasitic fungus indigenous to Taiwan. The structure of compound 1 was elucidated by the analysis of their spectroscopic data. Its cytotoxic activities were evaluated against MCF-7, MDA-MB-231 (human breast carcinoma), Hep3B, HepG2 (human liver carcinoma) and DU-145, LNCaP (human prostate carcinoma) cell lines, and the IC50 values ranged from 0.13 ± 0.02 to 6.09 ± 0.07 μM.

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A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata

Abstract

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