A new capnellene skeleton from the octocoral Capnella imbricata (Quoy & Gaimard, 1833)

I. Ting Wu, Yu Chen Fan, Guan Zhou Lin, Yi Lin Wang, Tsong Long Hwang, Kuei Hung Lai, Hsu Ming Chung

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Chemical investigations on the ethyl acetate extract of the octocoral Capnella imbricata collected from the waters of Taiwan, which led to the isolation of three capnellenes (1–3), including one new metabolite, △9(12)-capnellene-8β,10α,15-triol (1), along with two known metabolites, △9(12)-capnellene-5α,8β,10α-triol (2), and △9(12)-capnellene-8β,10α-diol (3). The structures of the isolated metabolites were elucidated through extensive spectroscopic analyses, while the relative stereochemistry of 3 was confirmed by a single-crystal X-ray diffraction analysis for the first time in this study. Compounds 1–3 were evaluated in terms of their anti-inflammatory activity by examining their inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.

Original languageEnglish
Article number133995
JournalJournal of Molecular Structure
Publication statusPublished - Jan 2023


  • Anti-inflammatory
  • Capnella imbricata
  • Capnellene
  • Octocoral
  • X-ray

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Inorganic Chemistry


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