A new γ-lactone from the leaves of Cinnamomum kotoense

Sien Sing Yang; Wen Chi Hou; Li Wei Huang; Zong-Huei Li

doi:10.1080/14786410600906236

A new γ-lactone from the leaves of Cinnamomum kotoense

Sien Sing Yang
, Wen Chi Hou
, Li Wei Huang
, Zong-Huei Li

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

A new C₁₉ γ-lactone, cinnakotolactone (1), along with a known analogue, isolinderanolide B (2), were isolated from the n-hexane layer of the leaf extracts of Cinnamomum kotoense. Their structures were elucidated on the basis of spectroscopic analysis. The anti-proliferation activities of 1 and 2 were evaluated against human HT29 and MCF-7 cancer cell lines, and their IC₅₀ values ranged from 3.3 ± 0.3 to 25.8 ± 5.3 μM.

Original language	English
Pages (from-to)	1246-1250
Number of pages	5
Journal	Natural Product Research
Volume	20
Issue number	13
DOIs	https://doi.org/10.1080/14786410600906236
Publication status	Published - Nov 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-proliferation activity
Cinnakotolactone
Cinnamomum kotoense
Lauraceae
Leaves

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Plant Science
Organic Chemistry

Access to Document

10.1080/14786410600906236

Cite this

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title = "A new γ-lactone from the leaves of Cinnamomum kotoense",

abstract = "A new C19 γ-lactone, cinnakotolactone (1), along with a known analogue, isolinderanolide B (2), were isolated from the n-hexane layer of the leaf extracts of Cinnamomum kotoense. Their structures were elucidated on the basis of spectroscopic analysis. The anti-proliferation activities of 1 and 2 were evaluated against human HT29 and MCF-7 cancer cell lines, and their IC50 values ranged from 3.3 ± 0.3 to 25.8 ± 5.3 μM.",

keywords = "Anti-proliferation activity, Cinnakotolactone, Cinnamomum kotoense, Lauraceae, Leaves",

author = "Yang, \{Sien Sing\} and Hou, \{Wen Chi\} and Huang, \{Li Wei\} and Zong-Huei Li",

note = "Funding Information: This research was supported by the grant from Cathy General Hospital (94CGH-TMU-14). We are grateful to Ms Shwu-Huey Wang and Ms Shou-Ling Huang for the NMR data acquisition in the Instrumentation Center of Taipei Medical University and Instrumentation Center of the College of Science, National Taiwan University, respectively.",

year = "2006",

month = nov,

doi = "10.1080/14786410600906236",

language = "English",

volume = "20",

pages = "1246--1250",

journal = "Natural Product Research",

issn = "1478-6419",

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T1 - A new γ-lactone from the leaves of Cinnamomum kotoense

AU - Yang, Sien Sing

AU - Hou, Wen Chi

AU - Huang, Li Wei

AU - Li, Zong-Huei

N1 - Funding Information: This research was supported by the grant from Cathy General Hospital (94CGH-TMU-14). We are grateful to Ms Shwu-Huey Wang and Ms Shou-Ling Huang for the NMR data acquisition in the Instrumentation Center of Taipei Medical University and Instrumentation Center of the College of Science, National Taiwan University, respectively.

PY - 2006/11

Y1 - 2006/11

N2 - A new C19 γ-lactone, cinnakotolactone (1), along with a known analogue, isolinderanolide B (2), were isolated from the n-hexane layer of the leaf extracts of Cinnamomum kotoense. Their structures were elucidated on the basis of spectroscopic analysis. The anti-proliferation activities of 1 and 2 were evaluated against human HT29 and MCF-7 cancer cell lines, and their IC50 values ranged from 3.3 ± 0.3 to 25.8 ± 5.3 μM.

AB - A new C19 γ-lactone, cinnakotolactone (1), along with a known analogue, isolinderanolide B (2), were isolated from the n-hexane layer of the leaf extracts of Cinnamomum kotoense. Their structures were elucidated on the basis of spectroscopic analysis. The anti-proliferation activities of 1 and 2 were evaluated against human HT29 and MCF-7 cancer cell lines, and their IC50 values ranged from 3.3 ± 0.3 to 25.8 ± 5.3 μM.

KW - Anti-proliferation activity

KW - Cinnakotolactone

KW - Cinnamomum kotoense

KW - Lauraceae

KW - Leaves

UR - https://www.scopus.com/pages/publications/37849189029

UR - https://www.scopus.com/pages/publications/37849189029#tab=citedBy

U2 - 10.1080/14786410600906236

DO - 10.1080/14786410600906236

M3 - Article

C2 - 17127517

AN - SCOPUS:37849189029

SN - 1478-6419

VL - 20

SP - 1246

EP - 1250

JO - Natural Product Research

JF - Natural Product Research

IS - 13

ER -

A new γ-lactone from the leaves of Cinnamomum kotoense

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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