TY - JOUR
T1 - A Neural "tuning Curve" for Multisensory Experience and Cognitive-Perceptual Schizotypy
AU - Ferri, Francesca
AU - Nikolova, Yuliya S.
AU - Perrucci, Mauro Gianni
AU - Costantini, Marcello
AU - Ferretti, Antonio
AU - Gatta, Valentina
AU - Huang, Zirui
AU - Edden, Richard A.E.
AU - Yue, Qiang
AU - D'Aurora, Marco
AU - Sibille, Etienne
AU - Stuppia, Liborio
AU - Romani, Gian Luca
AU - Northoff, Georg
N1 - Publisher Copyright:
© The Author 2017. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Our coherent perception of external events is enabled by the integration of inputs from different senses occurring within a range of temporal offsets known as the temporal binding window (TBW), which varies from person to person. A relatively wide TBW may increase the likelihood that stimuli originating from different environmental events are erroneously integrated and abnormally large TBW has been found in psychiatric disorders characterized by unusual perceptual experiences. Despite strong evidence of inter-individual differences in TBW, both within clinical and nonclinical populations, the neurobiological underpinnings of this variability remain unclear. We adopted an integrated strategy linking TBW to temporal dynamics in functional magnetic resonance imaging (fMRI)-resting-state activity and cortical excitation/inhibition (E/I) balance. E/I balance was indexed by glutamate/Gamma-AminoButyric Acid (GABA) concentrations and common variation in glutamate and GABA genes in a healthy sample. Stronger resting-state long-range temporal correlations, indicated by larger power law exponent (PLE), in the auditory cortex, robustly predicted narrower audio-tactile TBW, which was in turn associated with lower cognitive-perceptual schizotypy. Furthermore, PLE was highest and TBW narrowest for individuals with intermediate levels of E/I balance, with shifts towards either extreme resulting in reduced multisensory temporal precision and increased schizotypy, effectively forming a neural "tuning curve" for multisensory experience and schizophrenia risk. Our findings shed light on the neurobiological underpinnings of multisensory integration and its potentially clinically relevant inter-individual variability.
AB - Our coherent perception of external events is enabled by the integration of inputs from different senses occurring within a range of temporal offsets known as the temporal binding window (TBW), which varies from person to person. A relatively wide TBW may increase the likelihood that stimuli originating from different environmental events are erroneously integrated and abnormally large TBW has been found in psychiatric disorders characterized by unusual perceptual experiences. Despite strong evidence of inter-individual differences in TBW, both within clinical and nonclinical populations, the neurobiological underpinnings of this variability remain unclear. We adopted an integrated strategy linking TBW to temporal dynamics in functional magnetic resonance imaging (fMRI)-resting-state activity and cortical excitation/inhibition (E/I) balance. E/I balance was indexed by glutamate/Gamma-AminoButyric Acid (GABA) concentrations and common variation in glutamate and GABA genes in a healthy sample. Stronger resting-state long-range temporal correlations, indicated by larger power law exponent (PLE), in the auditory cortex, robustly predicted narrower audio-tactile TBW, which was in turn associated with lower cognitive-perceptual schizotypy. Furthermore, PLE was highest and TBW narrowest for individuals with intermediate levels of E/I balance, with shifts towards either extreme resulting in reduced multisensory temporal precision and increased schizotypy, effectively forming a neural "tuning curve" for multisensory experience and schizophrenia risk. Our findings shed light on the neurobiological underpinnings of multisensory integration and its potentially clinically relevant inter-individual variability.
KW - GABA (gamma-amminobutyric acid)
KW - excitation
KW - functional magnetic resonance imaging (fMRI) resting-state activity
KW - glutamate
KW - inhibition balance
KW - long-range temporal correlations
KW - multilocus genetic score
KW - multisensory perception
KW - schizotypy
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U2 - 10.1093/schbul/sbw174
DO - 10.1093/schbul/sbw174
M3 - Article
C2 - 28168302
AN - SCOPUS:85021814952
SN - 0586-7614
VL - 43
SP - 801
EP - 813
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
IS - 4
ER -