A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Ting Jing Shen, Ming Kai Jhan, Jo Chi Kao, Min Ru Ho, Tsung Ting Tsai, Po-Chun Tseng, Yung Ting Wang, Chiou-Feng Lin

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Dengue virus (DENV), an arthropod-borne virus transmitted by mosquitoes, may cause the severe disease known as dengue hemorrhagic fever, which is characterized by lethal complications due to plasma leakage, ascites, pleural effusion, respiratory distress, severe bleeding, and organ impairment. A few cases of DENV infection present neurological manifestations; however, studies have not explored DENV-induced neuropathogenesis further. In this study, we present a protocol to use an immunocompetent outbred ICR (Institute of Cancer Research) mouse for investigating the induction of central nervous system (CNS) infection with DENV, followed by the progression of acute viral encephalitis-like disease.
Original languageEnglish
JournalJournal of Visualized Experiments
Publication statusPublished - 2019


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