Abstract

Dengue virus (DENV), an arthropod-borne virus transmitted by mosquitoes, may cause the severe disease known as dengue hemorrhagic fever, which is characterized by lethal complications due to plasma leakage, ascites, pleural effusion, respiratory distress, severe bleeding, and organ impairment. A few cases of DENV infection present neurological manifestations; however, studies have not explored DENV-induced neuropathogenesis further. In this study, we present a protocol to use an immunocompetent outbred ICR (Institute of Cancer Research) mouse for investigating the induction of central nervous system (CNS) infection with DENV, followed by the progression of acute viral encephalitis-like disease.
Original languageEnglish
JournalJournal of Visualized Experiments
Publication statusPublished - 2019

Keywords

  • Dengue virus
  • Encephalitis
  • Immunology and infection
  • Intracerebral injection
  • Intraperitoneal injection
  • Issue 146
  • Murine
  • Neurotoxicity
  • Suckling mice

Fingerprint

Dive into the research topics of 'A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease'. Together they form a unique fingerprint.

Cite this