A model for tumor cell killing by topoisomerase poisons

H. Zhang, P. D'Arpa, Leroy-Fong Liu

Research output: Contribution to journalArticlepeer-review

175 Citations (Scopus)


Our model proposes that topoisomerase-targeting antitumor drugs form reversible drug-enzyme-DNA complexes that collide with the DNA and RNA synthesis machineries. On collisions, the complexes lose their reversibility, and generate lethal double-strand DNA breaks. Further investigations of topoisomerase action will allow this model to be refined, and may ultimately lead to the development of more effective anticancer drugs.

Original languageEnglish
Pages (from-to)23-26
Number of pages4
JournalCancer Cells
Issue number1
Publication statusPublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research


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