TY - GEN
T1 - A Labchip with Co-Cultured Spheroids Applied for HIPEC Cancer Drug Screening
AU - Hsieh, Chang Hung
AU - Huang, Wei Yu
AU - Hsieh, Mao Chih
AU - Tai, Yu Ting
AU - Chi, Jen Tsan Ashley
AU - Dong, Si Jin
AU - Liu, Cheng Hsien
N1 - Publisher Copyright:
© 2023 IEEJ.
PY - 2023
Y1 - 2023
N2 - Cancer has always been one of the health issues of concern to all walks of life. The reason why cancer is difficult to cure is that cancer cells will metastasize or spread to other parts of the body. However, the cancer cells in the abdominal cavity of patients are metastasized from colorectal cancer, rectal cancer, gastric cancer, etc. In recent years, Hyperthermic Intraperitoneal Chemotherapy (HIPEC), is an emerging therapy that has attracted attention. Based on Microelectromechanical technology, this research designs a multi-layer microfluidic chip, which has the function of the automatic combination of multiple drugs and co-culture of multicellular tumor spheroids in different cell proportions. With the heating device, the chip and drug temperature during drug perfusion was maintained at 37, 43 and 45 °C, respectively, to simulate and test the treatment process of intraperitoneal hyperthermic chemotherapy. This microfluidic system is developed with and aims to provide clinicians with screening the suitable drug combination for individual patients before surgery to approach precision medicine and customized treatment.
AB - Cancer has always been one of the health issues of concern to all walks of life. The reason why cancer is difficult to cure is that cancer cells will metastasize or spread to other parts of the body. However, the cancer cells in the abdominal cavity of patients are metastasized from colorectal cancer, rectal cancer, gastric cancer, etc. In recent years, Hyperthermic Intraperitoneal Chemotherapy (HIPEC), is an emerging therapy that has attracted attention. Based on Microelectromechanical technology, this research designs a multi-layer microfluidic chip, which has the function of the automatic combination of multiple drugs and co-culture of multicellular tumor spheroids in different cell proportions. With the heating device, the chip and drug temperature during drug perfusion was maintained at 37, 43 and 45 °C, respectively, to simulate and test the treatment process of intraperitoneal hyperthermic chemotherapy. This microfluidic system is developed with and aims to provide clinicians with screening the suitable drug combination for individual patients before surgery to approach precision medicine and customized treatment.
KW - Cancer metastasis
KW - Combinatorial chip
KW - HIPEC
KW - MEMS
KW - Microfluidics
KW - Multicellular tumor spheroids
UR - http://www.scopus.com/inward/record.url?scp=85193537264&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85193537264&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85193537264
T3 - 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023
SP - 1288
EP - 1291
BT - 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023
Y2 - 25 June 2023 through 29 June 2023
ER -
