TY - JOUR
T1 - A higher anti-Müllerian hormone level is associated with an increased chance of pregnancy in patients undergoing controlled ovarian stimulation and intrauterine insemination
AU - Wang, M. H.
AU - Chen, Chi-Huang
AU - Wang, Chia Wowi
AU - Hsu, Ming-I
AU - Tzeng, Chii-Ruey
N1 - Publisher Copyright:
© 2014 Informa UK, Ltd.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Anti-Müllerian hormone (AMH) level has been found to be a useful marker of ovarian reserve, and a predictor of poor and hyper-responses in patients undergoing controlled ovarian stimulation (COS). The study aimed to determine the association of serum AMH level with achieving pregnancy in patients undergoing COS with intrauterine insemination. The cross-sectional study investigated 204 patients who underwent COS with intrauterine insemination at the Obstetrics and Gynecology Department of Taipei Medical University Hospital, from January 2011 to March 2012. The medical records of these patients were reviewed, and serum AMH levels were evaluated for association with successful clinical pregnancy. The AMH level in the patients who achieved clinical pregnancy was significantly higher than in patients who did not (median 2.7 vs 2.0 ng/ml, p = 0.005). Controlling for factors affecting infertility, AMH level had a significant independent influence on outcome; a higher AMH level was associated with a decreased risk of a non-pregnant outcome (odds ratio, OR = 0.895, p = 0.026). In patients undergoing COS and intrauterine insemination, a low AMH level is associated with a decreased chance of a clinical pregnancy, and this association remains irrespective of the presence or absence of endometriosis.
AB - Anti-Müllerian hormone (AMH) level has been found to be a useful marker of ovarian reserve, and a predictor of poor and hyper-responses in patients undergoing controlled ovarian stimulation (COS). The study aimed to determine the association of serum AMH level with achieving pregnancy in patients undergoing COS with intrauterine insemination. The cross-sectional study investigated 204 patients who underwent COS with intrauterine insemination at the Obstetrics and Gynecology Department of Taipei Medical University Hospital, from January 2011 to March 2012. The medical records of these patients were reviewed, and serum AMH levels were evaluated for association with successful clinical pregnancy. The AMH level in the patients who achieved clinical pregnancy was significantly higher than in patients who did not (median 2.7 vs 2.0 ng/ml, p = 0.005). Controlling for factors affecting infertility, AMH level had a significant independent influence on outcome; a higher AMH level was associated with a decreased risk of a non-pregnant outcome (odds ratio, OR = 0.895, p = 0.026). In patients undergoing COS and intrauterine insemination, a low AMH level is associated with a decreased chance of a clinical pregnancy, and this association remains irrespective of the presence or absence of endometriosis.
KW - Anti-Müllerian hormone
KW - Controlled ovarian stimulation
KW - Infertility
KW - Intrauterine insemination
KW - in-vitro fertilisation
UR - http://www.scopus.com/inward/record.url?scp=84919455727&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84919455727&partnerID=8YFLogxK
U2 - 10.3109/01443615.2014.935718
DO - 10.3109/01443615.2014.935718
M3 - Article
C2 - 25010731
AN - SCOPUS:84919455727
SN - 0144-3615
VL - 35
SP - 64
EP - 68
JO - Journal of Obstetrics and Gynaecology
JF - Journal of Obstetrics and Gynaecology
IS - 1
ER -