A heavy-chain antibody-drug conjugate targeting glycosylated CEACAM6 inhibits brain metastatic tumor growth

Yao Tsung Tsai; Min Hsuan Yen; Ping Jen Hu; Cheng Chung Lee; Chang Yi Liu; Tsai Mu Cheng; Hsieh Tsung Shen; Bo Xiang Benjamin Zhang; Hsin Lun Lee; Kuo Hsiang Chuang; Chee Voon Yap; Wen Chang Wang; Ming Heng Wu

doi:10.1016/j.canlet.2026.218463

A heavy-chain antibody-drug conjugate targeting glycosylated CEACAM6 inhibits brain metastatic tumor growth

Yao Tsung Tsai
, Min Hsuan Yen
, Ping Jen Hu
, Cheng Chung Lee
, Chang Yi Liu
, Tsai Mu Cheng
, Hsieh Tsung Shen
, Bo Xiang Benjamin Zhang
, Hsin Lun Lee
, Kuo Hsiang Chuang
, Chee Voon Yap
, Wen Chang Wang
, Ming Heng Wu

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	218463
Journal	Cancer Letters
Volume	648
DOIs	https://doi.org/10.1016/j.canlet.2026.218463
Publication status	Published - Jun 28 2026

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.canlet.2026.218463

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Tsai, Y. T., Yen, M. H., Hu, P. J., Lee, C. C., Liu, C. Y., Cheng, T. M., Shen, H. T., Benjamin Zhang, B. X., Lee, H. L., Chuang, K. H., Yap, C. V., Wang, W. C., & Wu, M. H. (2026). A heavy-chain antibody-drug conjugate targeting glycosylated CEACAM6 inhibits brain metastatic tumor growth. Cancer Letters, 648, Article 218463. https://doi.org/10.1016/j.canlet.2026.218463

@article{b2dc2a4f76c7415d96a37bc0ab83ff78,

title = "A heavy-chain antibody-drug conjugate targeting glycosylated CEACAM6 inhibits brain metastatic tumor growth",

author = "Tsai, \{Yao Tsung\} and Yen, \{Min Hsuan\} and Hu, \{Ping Jen\} and Lee, \{Cheng Chung\} and Liu, \{Chang Yi\} and Cheng, \{Tsai Mu\} and Shen, \{Hsieh Tsung\} and \{Benjamin Zhang\}, \{Bo Xiang\} and Lee, \{Hsin Lun\} and Chuang, \{Kuo Hsiang\} and Yap, \{Chee Voon\} and Wang, \{Wen Chang\} and Wu, \{Ming Heng\}",

year = "2026",

month = jun,

day = "28",

doi = "10.1016/j.canlet.2026.218463",

language = "English",

volume = "648",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

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TY - JOUR

T1 - A heavy-chain antibody-drug conjugate targeting glycosylated CEACAM6 inhibits brain metastatic tumor growth

AU - Tsai, Yao Tsung

AU - Yen, Min Hsuan

AU - Hu, Ping Jen

AU - Lee, Cheng Chung

AU - Liu, Chang Yi

AU - Cheng, Tsai Mu

AU - Shen, Hsieh Tsung

AU - Benjamin Zhang, Bo Xiang

AU - Lee, Hsin Lun

AU - Chuang, Kuo Hsiang

AU - Yap, Chee Voon

AU - Wang, Wen Chang

AU - Wu, Ming Heng

PY - 2026/6/28

Y1 - 2026/6/28

UR - https://www.scopus.com/pages/publications/105034498566

UR - https://www.scopus.com/pages/publications/105034498566#tab=citedBy

U2 - 10.1016/j.canlet.2026.218463

DO - 10.1016/j.canlet.2026.218463

M3 - Article

C2 - 41912133

AN - SCOPUS:105034498566

SN - 0304-3835

VL - 648

JO - Cancer Letters

JF - Cancer Letters

M1 - 218463

ER -

A heavy-chain antibody-drug conjugate targeting glycosylated CEACAM6 inhibits brain metastatic tumor growth

ASJC Scopus subject areas

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