A facile method for the synthesis of glaucine and norglaucine from boldine

Wei Jan Huang; Chung Hsiung Chen; Om V. Singh; Su Lin Lee; Shoei Sheng Lee

doi:10.1081/SCC-120014988

A facile method for the synthesis of glaucine and norglaucine from boldine

Wei Jan Huang, Chung Hsiung Chen, Om V. Singh, Su Lin Lee, Shoei Sheng Lee

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

A large-scale preparation of glaucine was achieved by reacting boldine with trimethylphenylammonium chloride and potassium t-butoxide in high yield. Treatment of glaucine with 30% H202, subsequent with hydrated ferrous sulfate, afforded norglaucine in an overall yield of 40%.

Original language	English
Pages (from-to)	3681-3686
Number of pages	6
Journal	Synthetic Communications
Volume	32
Issue number	23
DOIs	https://doi.org/10.1081/SCC-120014988
Publication status	Published - 2002

Keywords

Glaucine
Large-scale preparation
Norglaucine

ASJC Scopus subject areas

Organic Chemistry

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10.1081/SCC-120014988

Cite this

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title = "A facile method for the synthesis of glaucine and norglaucine from boldine",

abstract = "A large-scale preparation of glaucine was achieved by reacting boldine with trimethylphenylammonium chloride and potassium t-butoxide in high yield. Treatment of glaucine with 30% H202, subsequent with hydrated ferrous sulfate, afforded norglaucine in an overall yield of 40%.",

keywords = "Glaucine, Large-scale preparation, Norglaucine",

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AU - Huang, Wei Jan

AU - Chen, Chung Hsiung

AU - Singh, Om V.

AU - Lee, Su Lin

AU - Lee, Shoei Sheng

PY - 2002

Y1 - 2002

N2 - A large-scale preparation of glaucine was achieved by reacting boldine with trimethylphenylammonium chloride and potassium t-butoxide in high yield. Treatment of glaucine with 30% H202, subsequent with hydrated ferrous sulfate, afforded norglaucine in an overall yield of 40%.

AB - A large-scale preparation of glaucine was achieved by reacting boldine with trimethylphenylammonium chloride and potassium t-butoxide in high yield. Treatment of glaucine with 30% H202, subsequent with hydrated ferrous sulfate, afforded norglaucine in an overall yield of 40%.

KW - Glaucine

KW - Large-scale preparation

KW - Norglaucine

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A facile method for the synthesis of glaucine and norglaucine from boldine

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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