A Dynamic Model for Estimating the Retention Duration of Neutralizing Antibody Titers After Vaccination in a COVID-19 Convalescent Population

Fang Chi Hsu; Li Chern Pan; Yen Fang Huang; Chin Hui Yang; Ming Neng Shiu; Hsiu Ju Lin

doi:10.1093/infdis/jiad431

A Dynamic Model for Estimating the Retention Duration of Neutralizing Antibody Titers After Vaccination in a COVID-19 Convalescent Population

Fang Chi Hsu, Li Chern Pan, Yen Fang Huang, Chin Hui Yang, Ming Neng Shiu, Hsiu Ju Lin

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We measured neutralizing antibodies (nAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a cohort of 235 convalescent patients (representing 384 analytic samples). They were followed for up to 588 days after the first report of onset in Taiwan. A proposed Bayesian approach was used to estimate nAb dynamics in patients postvaccination. This model revealed that the titer reached its peak (1819.70 IU/mL) by 161 days postvaccination and decreased to 154.18 IU/mL by day 360. Thus, the nAb titers declined in 6 months after vaccination. Protection, against variant B.1.1.529 (ie, Omicron) may only occur during the peak period.

Original language	English
Pages (from-to)	398-402
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	229
Issue number	2
DOIs	https://doi.org/10.1093/infdis/jiad431
Publication status	Published - Feb 15 2024

Keywords

Bayesian
COVID-19
Markov chain Monte Carlo
neutralizing antibody titer

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiad431

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title = "A Dynamic Model for Estimating the Retention Duration of Neutralizing Antibody Titers After Vaccination in a COVID-19 Convalescent Population",

abstract = "We measured neutralizing antibodies (nAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a cohort of 235 convalescent patients (representing 384 analytic samples). They were followed for up to 588 days after the first report of onset in Taiwan. A proposed Bayesian approach was used to estimate nAb dynamics in patients postvaccination. This model revealed that the titer reached its peak (1819.70 IU/mL) by 161 days postvaccination and decreased to 154.18 IU/mL by day 360. Thus, the nAb titers declined in 6 months after vaccination. Protection, against variant B.1.1.529 (ie, Omicron) may only occur during the peak period.",

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AU - Yang, Chin Hui

AU - Shiu, Ming Neng

AU - Lin, Hsiu Ju

PY - 2024/2/15

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A Dynamic Model for Estimating the Retention Duration of Neutralizing Antibody Titers After Vaccination in a COVID-19 Convalescent Population

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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