TY - JOUR
T1 - A dose-dependent pharmacokinetic study on caffeic acid in rabbits after intravenous administration
AU - Uang, Yow Shieng
AU - Hsu, Kuang Yang
PY - 1997
Y1 - 1997
N2 - The dose-dependent pharmacokinetics of caffeic acid (CA) were studied in rabbits. Three different doses (5, 10, and 25mg kg-1) were administered intravenously to six rabbits each. The concentration-time profiles for CA could be fitted by a two-compartment model for each dose. The results showed that total-body clearance and elimination rate constant from the central compartment (k10) after a 5 mg kg-1 dose were greater than those after the other two doses. Furthermore, the terminal elimination half-life (β half-life) and mean residence time (MRT) after a 5 mg kg-1 dose were less than after the other doses. The AUC value increased linearly with dose within the range of 10-25 mg kg-1. Most of the unchanged caffeic acid was excreted in the urine within 2 h. The percentage of unchanged caffeic acid excreted in the urine was 63.4, 60.0, and 55.4% after doses of 5, 10, and 25 mg kg-1, respectively, which was not significantly different. However, significant differences in the renal clearances and renal excretion rate constants were observed with a 5 mg kg-1 dose compared to the other doses. On the other hand, nonrenal clearances and nonrenal excretion rate constants showed no dose-related differences. The differences observed in total-body clearance, k10, β half-life, and MRT between a 5 mg kg-1 dose and the ether doses can be explained on the basis of the differences in renal clearance and renal excretion rate constants.
AB - The dose-dependent pharmacokinetics of caffeic acid (CA) were studied in rabbits. Three different doses (5, 10, and 25mg kg-1) were administered intravenously to six rabbits each. The concentration-time profiles for CA could be fitted by a two-compartment model for each dose. The results showed that total-body clearance and elimination rate constant from the central compartment (k10) after a 5 mg kg-1 dose were greater than those after the other two doses. Furthermore, the terminal elimination half-life (β half-life) and mean residence time (MRT) after a 5 mg kg-1 dose were less than after the other doses. The AUC value increased linearly with dose within the range of 10-25 mg kg-1. Most of the unchanged caffeic acid was excreted in the urine within 2 h. The percentage of unchanged caffeic acid excreted in the urine was 63.4, 60.0, and 55.4% after doses of 5, 10, and 25 mg kg-1, respectively, which was not significantly different. However, significant differences in the renal clearances and renal excretion rate constants were observed with a 5 mg kg-1 dose compared to the other doses. On the other hand, nonrenal clearances and nonrenal excretion rate constants showed no dose-related differences. The differences observed in total-body clearance, k10, β half-life, and MRT between a 5 mg kg-1 dose and the ether doses can be explained on the basis of the differences in renal clearance and renal excretion rate constants.
KW - Caffeic acid
KW - Renal clearance
KW - Renal excretion rate constant
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U2 - 10.1002/(SICI)1099-081X(199711)18:8<727::AID-BDD58>3.0.CO;2-F
DO - 10.1002/(SICI)1099-081X(199711)18:8<727::AID-BDD58>3.0.CO;2-F
M3 - Article
C2 - 9373729
AN - SCOPUS:0030661613
SN - 0142-2782
VL - 18
SP - 727
EP - 736
JO - Biopharmaceutics and Drug Disposition
JF - Biopharmaceutics and Drug Disposition
IS - 8
ER -