A concise synthesis of denbinobin

Yu Chieh Wang; Chien Huang Lin; Chi-Ming Chen; Jing Ping Liou

doi:10.1016/j.tetlet.2005.09.118

A concise synthesis of denbinobin

Yu Chieh Wang, Chien Huang Lin, Chi-Ming Chen, Jing Ping Liou

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

A concise synthesis of denbinobin is described via an intramolecular free radical cyclization and Fremy's salt mediated oxidation as a key reactions. A seven-step process starting from commercially available 3,5-dimethoxybenzyl bromide (6) and 2-bromoisovanillin (5) effectively constructs the natural product denbinobin (1).

Original language	English
Pages (from-to)	8103-8104
Number of pages	2
Journal	Tetrahedron Letters
Volume	46
Issue number	47
DOIs	https://doi.org/10.1016/j.tetlet.2005.09.118
Publication status	Published - Nov 21 2005

Keywords

Free radical cyclization
Fremy's salt oxidation
Natural product

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2005.09.118

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abstract = "A concise synthesis of denbinobin is described via an intramolecular free radical cyclization and Fremy's salt mediated oxidation as a key reactions. A seven-step process starting from commercially available 3,5-dimethoxybenzyl bromide (6) and 2-bromoisovanillin (5) effectively constructs the natural product denbinobin (1).",

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AU - Wang, Yu Chieh

AU - Lin, Chien Huang

AU - Chen, Chi-Ming

AU - Liou, Jing Ping

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N2 - A concise synthesis of denbinobin is described via an intramolecular free radical cyclization and Fremy's salt mediated oxidation as a key reactions. A seven-step process starting from commercially available 3,5-dimethoxybenzyl bromide (6) and 2-bromoisovanillin (5) effectively constructs the natural product denbinobin (1).

AB - A concise synthesis of denbinobin is described via an intramolecular free radical cyclization and Fremy's salt mediated oxidation as a key reactions. A seven-step process starting from commercially available 3,5-dimethoxybenzyl bromide (6) and 2-bromoisovanillin (5) effectively constructs the natural product denbinobin (1).

KW - Free radical cyclization

KW - Fremy's salt oxidation

KW - Natural product

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ER -

A concise synthesis of denbinobin

Abstract

Keywords

ASJC Scopus subject areas

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