Abstract
A concise synthesis of denbinobin is described via an intramolecular free radical cyclization and Fremy's salt mediated oxidation as a key reactions. A seven-step process starting from commercially available 3,5-dimethoxybenzyl bromide (6) and 2-bromoisovanillin (5) effectively constructs the natural product denbinobin (1).
Original language | English |
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Pages (from-to) | 8103-8104 |
Number of pages | 2 |
Journal | Tetrahedron Letters |
Volume | 46 |
Issue number | 47 |
DOIs | |
Publication status | Published - Nov 21 2005 |
Keywords
- Free radical cyclization
- Fremy's salt oxidation
- Natural product
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry