A comparison of safety, tolerability and immunogenicity of Oka/Merck varicella vaccine and VARILRIX™ in healthy children

Yu Lung Lau; S. J.Rupert Vessey; Ivan S.F. Chan; Tsz Leung Lee; Li Min Huang; Chin Yun Lee; Tzou-Yien Lin; Bee Wah Lee; Kow Kwan; Siti M. Kasim; Christina Y. Chan; Karen M. Kaplan; Daniel J. Distefano; Anna L. Harmon; Amy Golie; Jonathan Hartzel; Jin Xu; Shu Li; Holly Matthews; Jerald C. Sadoff; Alan Shaw

doi:10.1016/S0264-410X(02)00245-1

A comparison of safety, tolerability and immunogenicity of Oka/Merck varicella vaccine and VARILRIX™ in healthy children

Yu Lung Lau
, S. J.Rupert Vessey
, Ivan S.F. Chan
, Tsz Leung Lee
, Li Min Huang
, Chin Yun Lee
, Tzou-Yien Lin
, Bee Wah Lee
, Kow Kwan
, Siti M. Kasim
, Christina Y. Chan
, Karen M. Kaplan
, Daniel J. Distefano
, Anna L. Harmon
, Amy Golie
, Jonathan Hartzel
, Jin Xu
, Shu Li
, Holly Matthews
, Jerald C. Sadoff

Alan Shaw

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

This study compared safety, tolerability, and immunogenicity of the Oka/Merck varicella vaccine and VARILRIX™ [Oka-RIT strain SmithKline Beecham Biologicals] in healthy children 12-24 months of age. Subjects were randomized in this double blind study to receive either a single dose of Oka/Merck varicella vaccine, (∼50,000 plaque forming units (PFU), Group A or ∼16,000PFU, Group B) or 1 dose of VARILRIX™, (∼40,000PFU/dose, Group C). Safety profiles in each treatment group were similar. The proportions of subjects achieving a 6-week postvaccination titer ≥5 gpELISA units in Groups A, B or C were 97.1, 95.2 and 85.6%, respectively.

Original language	English
Pages (from-to)	2942-2949
Number of pages	8
Journal	Vaccine
Volume	20
Issue number	23-24
DOIs	https://doi.org/10.1016/S0264-410X(02)00245-1
Publication status	Published - Jul 26 2002
Externally published	Yes

Keywords

Immunogenicity
Varicella vaccination
Varicella zoster virus

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/S0264-410X(02)00245-1

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Lau, Y. L., Vessey, S. J. R., Chan, I. S. F., Lee, T. L., Huang, L. M., Lee, C. Y., Lin, T.-Y., Lee, B. W., Kwan, K., Kasim, S. M., Chan, C. Y., Kaplan, K. M., Distefano, D. J., Harmon, A. L., Golie, A., Hartzel, J., Xu, J., Li, S., Matthews, H., ... Shaw, A. (2002). A comparison of safety, tolerability and immunogenicity of Oka/Merck varicella vaccine and VARILRIX™ in healthy children. Vaccine, 20(23-24), 2942-2949. https://doi.org/10.1016/S0264-410X(02)00245-1

Lau, YL, Vessey, SJR, Chan, ISF, Lee, TL, Huang, LM, Lee, CY, Lin, T-Y, Lee, BW, Kwan, K, Kasim, SM, Chan, CY, Kaplan, KM, Distefano, DJ, Harmon, AL, Golie, A, Hartzel, J, Xu, J, Li, S, Matthews, H, Sadoff, JC & Shaw, A 2002, 'A comparison of safety, tolerability and immunogenicity of Oka/Merck varicella vaccine and VARILRIX™ in healthy children', Vaccine, vol. 20, no. 23-24, pp. 2942-2949. https://doi.org/10.1016/S0264-410X(02)00245-1

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title = "A comparison of safety, tolerability and immunogenicity of Oka/Merck varicella vaccine and VARILRIX{\texttrademark} in healthy children",

abstract = "This study compared safety, tolerability, and immunogenicity of the Oka/Merck varicella vaccine and VARILRIX{\texttrademark} [Oka-RIT strain SmithKline Beecham Biologicals] in healthy children 12-24 months of age. Subjects were randomized in this double blind study to receive either a single dose of Oka/Merck varicella vaccine, (∼50,000 plaque forming units (PFU), Group A or ∼16,000PFU, Group B) or 1 dose of VARILRIX{\texttrademark}, (∼40,000PFU/dose, Group C). Safety profiles in each treatment group were similar. The proportions of subjects achieving a 6-week postvaccination titer ≥5 gpELISA units in Groups A, B or C were 97.1, 95.2 and 85.6\%, respectively.",

keywords = "Immunogenicity, Varicella vaccination, Varicella zoster virus",

author = "Lau, \{Yu Lung\} and Vessey, \{S. J.Rupert\} and Chan, \{Ivan S.F.\} and Lee, \{Tsz Leung\} and Huang, \{Li Min\} and Lee, \{Chin Yun\} and Tzou-Yien Lin and Lee, \{Bee Wah\} and Kow Kwan and Kasim, \{Siti M.\} and Chan, \{Christina Y.\} and Kaplan, \{Karen M.\} and Distefano, \{Daniel J.\} and Harmon, \{Anna L.\} and Amy Golie and Jonathan Hartzel and Jin Xu and Shu Li and Holly Matthews and Sadoff, \{Jerald C.\} and Alan Shaw",

note = "Funding Information: This study was supported by a grant from Merck \& Co. Inc.",

year = "2002",

month = jul,

day = "26",

doi = "10.1016/S0264-410X(02)00245-1",

language = "English",

volume = "20",

pages = "2942--2949",

journal = "Vaccine",

issn = "0264-410X",

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T1 - A comparison of safety, tolerability and immunogenicity of Oka/Merck varicella vaccine and VARILRIX™ in healthy children

AU - Lau, Yu Lung

AU - Vessey, S. J.Rupert

AU - Chan, Ivan S.F.

AU - Lee, Tsz Leung

AU - Huang, Li Min

AU - Lee, Chin Yun

AU - Lin, Tzou-Yien

AU - Lee, Bee Wah

AU - Kwan, Kow

AU - Kasim, Siti M.

AU - Chan, Christina Y.

AU - Kaplan, Karen M.

AU - Distefano, Daniel J.

AU - Harmon, Anna L.

AU - Golie, Amy

AU - Hartzel, Jonathan

AU - Xu, Jin

AU - Li, Shu

AU - Matthews, Holly

AU - Sadoff, Jerald C.

AU - Shaw, Alan

N1 - Funding Information: This study was supported by a grant from Merck & Co. Inc.

PY - 2002/7/26

Y1 - 2002/7/26

N2 - This study compared safety, tolerability, and immunogenicity of the Oka/Merck varicella vaccine and VARILRIX™ [Oka-RIT strain SmithKline Beecham Biologicals] in healthy children 12-24 months of age. Subjects were randomized in this double blind study to receive either a single dose of Oka/Merck varicella vaccine, (∼50,000 plaque forming units (PFU), Group A or ∼16,000PFU, Group B) or 1 dose of VARILRIX™, (∼40,000PFU/dose, Group C). Safety profiles in each treatment group were similar. The proportions of subjects achieving a 6-week postvaccination titer ≥5 gpELISA units in Groups A, B or C were 97.1, 95.2 and 85.6%, respectively.

AB - This study compared safety, tolerability, and immunogenicity of the Oka/Merck varicella vaccine and VARILRIX™ [Oka-RIT strain SmithKline Beecham Biologicals] in healthy children 12-24 months of age. Subjects were randomized in this double blind study to receive either a single dose of Oka/Merck varicella vaccine, (∼50,000 plaque forming units (PFU), Group A or ∼16,000PFU, Group B) or 1 dose of VARILRIX™, (∼40,000PFU/dose, Group C). Safety profiles in each treatment group were similar. The proportions of subjects achieving a 6-week postvaccination titer ≥5 gpELISA units in Groups A, B or C were 97.1, 95.2 and 85.6%, respectively.

KW - Immunogenicity

KW - Varicella vaccination

KW - Varicella zoster virus

UR - https://www.scopus.com/pages/publications/0037178307

UR - https://www.scopus.com/pages/publications/0037178307#tab=citedBy

U2 - 10.1016/S0264-410X(02)00245-1

DO - 10.1016/S0264-410X(02)00245-1

M3 - Article

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AN - SCOPUS:0037178307

SN - 0264-410X

VL - 20

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EP - 2949

JO - Vaccine

JF - Vaccine

IS - 23-24

ER -

A comparison of safety, tolerability and immunogenicity of Oka/Merck varicella vaccine and VARILRIX™ in healthy children

Abstract

Keywords

ASJC Scopus subject areas

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