A cohort study to evaluate the effectiveness of laparoscopic-guided local injection of etoposide in the management of women with unruptured tubal pregnancy

Ching Hui Chen; Wen Ling Lee; Li Hsuan Chiu; Hsu Dong Sun; Wei-Min Liu; Peng Hui Wang

doi:10.1016/j.fertnstert.2011.06.033

A cohort study to evaluate the effectiveness of laparoscopic-guided local injection of etoposide in the management of women with unruptured tubal pregnancy

Ching Hui Chen, Wen Ling Lee, Li Hsuan Chiu, Hsu Dong Sun, Wei-Min Liu, Peng Hui Wang

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Objective: To assess the feasibility of laparoscopic-guided local injection of etoposide or methotrexate (MTX) in the management of unruptured tubal pregnancy and compare the effectiveness of the two regimens. Design: Retrospective cohort study. Setting: Medical center. Patient(s): Thirty-one women with laparoscopically diagnosed unruptured tubal pregnancy. Intervention(s): A regimen of etoposide 50 mg via laparoscopic-guided local injection (n = 17) compared with a conventional MTX 50 mg regimen (n = 11), after 3 patients were excluded (2 refusals and 1 with salpingostomy). Main Outcome Measure(s): Serial serum β-hCG levels and the success rate in both groups. Result(s): General characteristics of the patients were similar in both groups. The overall success rate was 96.4% (27 of 28). The duration between treatment and nadir of serum β-hCG level (

Original language	English
Pages (from-to)	654-658
Number of pages	5
Journal	Fertility and Sterility
Volume	96
Issue number	3
DOIs	https://doi.org/10.1016/j.fertnstert.2011.06.033
Publication status	Published - Sept 2011

Keywords

conservative treatment
etoposide
laparoscopic-guided local injection
methotrexate
β-human chorionic gonadotropin

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynaecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.fertnstert.2011.06.033

Cite this

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title = "A cohort study to evaluate the effectiveness of laparoscopic-guided local injection of etoposide in the management of women with unruptured tubal pregnancy",

abstract = "Objective: To assess the feasibility of laparoscopic-guided local injection of etoposide or methotrexate (MTX) in the management of unruptured tubal pregnancy and compare the effectiveness of the two regimens. Design: Retrospective cohort study. Setting: Medical center. Patient(s): Thirty-one women with laparoscopically diagnosed unruptured tubal pregnancy. Intervention(s): A regimen of etoposide 50 mg via laparoscopic-guided local injection (n = 17) compared with a conventional MTX 50 mg regimen (n = 11), after 3 patients were excluded (2 refusals and 1 with salpingostomy). Main Outcome Measure(s): Serial serum β-hCG levels and the success rate in both groups. Result(s): General characteristics of the patients were similar in both groups. The overall success rate was 96.4% (27 of 28). The duration between treatment and nadir of serum β-hCG level (",

keywords = "conservative treatment, etoposide, laparoscopic-guided local injection, methotrexate, β-human chorionic gonadotropin",

author = "Chen, {Ching Hui} and Lee, {Wen Ling} and Chiu, {Li Hsuan} and Sun, {Hsu Dong} and Wei-Min Liu and Wang, {Peng Hui}",

note = "Funding Information: This work was supported in part by grants from Taipei Medical University, Taipei Veterans General Hospital ( V99F-014 , VGHUST99-G4 , and V100C-054 ), Taiwan. ",

year = "2011",

month = sep,

doi = "10.1016/j.fertnstert.2011.06.033",

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AU - Chen, Ching Hui

AU - Lee, Wen Ling

AU - Chiu, Li Hsuan

AU - Sun, Hsu Dong

AU - Liu, Wei-Min

AU - Wang, Peng Hui

N1 - Funding Information: This work was supported in part by grants from Taipei Medical University, Taipei Veterans General Hospital ( V99F-014 , VGHUST99-G4 , and V100C-054 ), Taiwan.

PY - 2011/9

Y1 - 2011/9

N2 - Objective: To assess the feasibility of laparoscopic-guided local injection of etoposide or methotrexate (MTX) in the management of unruptured tubal pregnancy and compare the effectiveness of the two regimens. Design: Retrospective cohort study. Setting: Medical center. Patient(s): Thirty-one women with laparoscopically diagnosed unruptured tubal pregnancy. Intervention(s): A regimen of etoposide 50 mg via laparoscopic-guided local injection (n = 17) compared with a conventional MTX 50 mg regimen (n = 11), after 3 patients were excluded (2 refusals and 1 with salpingostomy). Main Outcome Measure(s): Serial serum β-hCG levels and the success rate in both groups. Result(s): General characteristics of the patients were similar in both groups. The overall success rate was 96.4% (27 of 28). The duration between treatment and nadir of serum β-hCG level (

AB - Objective: To assess the feasibility of laparoscopic-guided local injection of etoposide or methotrexate (MTX) in the management of unruptured tubal pregnancy and compare the effectiveness of the two regimens. Design: Retrospective cohort study. Setting: Medical center. Patient(s): Thirty-one women with laparoscopically diagnosed unruptured tubal pregnancy. Intervention(s): A regimen of etoposide 50 mg via laparoscopic-guided local injection (n = 17) compared with a conventional MTX 50 mg regimen (n = 11), after 3 patients were excluded (2 refusals and 1 with salpingostomy). Main Outcome Measure(s): Serial serum β-hCG levels and the success rate in both groups. Result(s): General characteristics of the patients were similar in both groups. The overall success rate was 96.4% (27 of 28). The duration between treatment and nadir of serum β-hCG level (

KW - conservative treatment

KW - etoposide

KW - laparoscopic-guided local injection

KW - methotrexate

KW - β-human chorionic gonadotropin

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A cohort study to evaluate the effectiveness of laparoscopic-guided local injection of etoposide in the management of women with unruptured tubal pregnancy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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