A bronchial epithelium-mimetic microfluidic chip system for investigating microenvironmental change-induced inflammatory process

Tushar Harishchandra Punde; Wen Hao Wu; Pei Chun Lien; Po Chen Shih; Margaret Dah Tsyr Chang; Kang Yun Lee; Han Pin Kuo; Cheng Hsien Liu

A bronchial epithelium-mimetic microfluidic chip system for investigating microenvironmental change-induced inflammatory process

Tushar Harishchandra Punde, Wen Hao Wu, Pei Chun Lien, Po Chen Shih, Margaret Dah Tsyr Chang, Kang Yun Lee, Han Pin Kuo, Cheng Hsien Liu

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We report a 3D biomimetic microsystem which mimics lung microenvironment for monitoring the role of chemokine induced lung inflammation. The extravasation of fibrocytes in response to eosinophil cationic protein (ECP)-stimulated bronchial epithelial cells induced lung inflammation was mimicked on the micro-fluidic chip system for monitoring the microenvironmental changes.

Original language	English
Title of host publication	Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
Publisher	Chemical and Biological Microsystems Society
Pages	1021-1023
Number of pages	3
ISBN (Print)	9780979806452
Publication status	Published - 2012
Externally published	Yes
Event	16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan Duration: Oct 28 2012 → Nov 1 2012

Other

Other	16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
Country/Territory	Japan
City	Okinawa
Period	10/28/12 → 11/1/12

Keywords

Biomimetics
Bronchial asthma
Eosinophil cationic protein
Fibrocytes
Microfluidic chip

ASJC Scopus subject areas

Chemical Engineering (miscellaneous)
Bioengineering

Cite this

Punde, T. H., Wu, W. H., Lien, P. C., Shih, P. C., Chang, M. D. T., Lee, K. Y., Kuo, H. P., & Liu, C. H. (2012). A bronchial epithelium-mimetic microfluidic chip system for investigating microenvironmental change-induced inflammatory process. In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 (pp. 1021-1023). Chemical and Biological Microsystems Society.

A bronchial epithelium-mimetic microfluidic chip system for investigating microenvironmental change-induced inflammatory process. / Punde, Tushar Harishchandra; Wu, Wen Hao; Lien, Pei Chun et al.
Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, 2012. p. 1021-1023.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Punde, TH, Wu, WH, Lien, PC, Shih, PC, Chang, MDT, Lee, KY , Kuo, HP & Liu, CH 2012, A bronchial epithelium-mimetic microfluidic chip system for investigating microenvironmental change-induced inflammatory process. in Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, pp. 1021-1023, 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012, Okinawa, Japan, 10/28/12.

Punde TH, Wu WH, Lien PC, Shih PC, Chang MDT, Lee KY et al. A bronchial epithelium-mimetic microfluidic chip system for investigating microenvironmental change-induced inflammatory process. In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society. 2012. p. 1021-1023

Punde, Tushar Harishchandra ; Wu, Wen Hao ; Lien, Pei Chun et al. / A bronchial epithelium-mimetic microfluidic chip system for investigating microenvironmental change-induced inflammatory process. Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, 2012. pp. 1021-1023

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abstract = "We report a 3D biomimetic microsystem which mimics lung microenvironment for monitoring the role of chemokine induced lung inflammation. The extravasation of fibrocytes in response to eosinophil cationic protein (ECP)-stimulated bronchial epithelial cells induced lung inflammation was mimicked on the micro-fluidic chip system for monitoring the microenvironmental changes.",

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AU - Punde, Tushar Harishchandra

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AU - Lien, Pei Chun

AU - Shih, Po Chen

AU - Chang, Margaret Dah Tsyr

AU - Lee, Kang Yun

AU - Kuo, Han Pin

AU - Liu, Cheng Hsien

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AB - We report a 3D biomimetic microsystem which mimics lung microenvironment for monitoring the role of chemokine induced lung inflammation. The extravasation of fibrocytes in response to eosinophil cationic protein (ECP)-stimulated bronchial epithelial cells induced lung inflammation was mimicked on the micro-fluidic chip system for monitoring the microenvironmental changes.

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KW - Bronchial asthma

KW - Eosinophil cationic protein

KW - Fibrocytes

KW - Microfluidic chip

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PB - Chemical and Biological Microsystems Society

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A bronchial epithelium-mimetic microfluidic chip system for investigating microenvironmental change-induced inflammatory process

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Keywords

ASJC Scopus subject areas

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