A 0.5V 1.27mW nose-on-a-chip for rapid diagnosis of ventilator-associated pneumonia

Kea Tiong Tang; Shih Wen Chiu; Chung-Hung Shih; Chia Ling Chang; Chia Min Yang; Da Jeng Yao; Jen Huo Wang; Chien Ming Huang; Hsin Chen; Kwuang Han Chang; Chih Cheng Hsieh; Ting Hau Chang; Meng Fan Chang; Chia Min Wang; Yi Wen Liu; Tsan Jieh Chen; Chia Hsiang Yang; Herming Chiueh; Jyuo Min Shyu

doi:10.1109/ISSCC.2014.6757496

A 0.5V 1.27mW nose-on-a-chip for rapid diagnosis of ventilator-associated pneumonia

Kea Tiong Tang, Shih Wen Chiu, Chung-Hung Shih, Chia Ling Chang, Chia Min Yang, Da Jeng Yao, Jen Huo Wang, Chien Ming Huang, Hsin Chen, Kwuang Han Chang, Chih Cheng Hsieh, Ting Hau Chang, Meng Fan Chang, Chia Min Wang, Yi Wen Liu, Tsan Jieh Chen, Chia Hsiang Yang, Herming Chiueh, Jyuo Min Shyu

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

21 Citations (Scopus)

Abstract

Ventilator-associated pneumonia (VAP) is the most frequently acquired infection among patients that receive mechanical ventilation in the intensive-care unit (ICU). The mortality rate for VAP lies in the 20-to-50% range and could be even higher in some ICUs. A standard operation procedure to VAP treatment includes a sequence of chest radiography, sputum gram stain, sputum culture, and empiric therapy, initially with antibiotics covering broad pathogens. However, collection of the gram stain and culture of lower respiratory tract specimen is usually not time-efficient (up to 5 days), delaying the initiation of therapy and unacceptable for critically ill patients. A rapid and accurate diagnosis for VAP is therefore crucial, but still unavailable. It is known that microorganisms generate complex metabolites during infection. Fast detection is feasible by examining metabolic wastes in proximal end of the expiratory device, demanding a miniaturized, battery-powered, gas-sensing device. In this work, a fully integrated low-power nose-on-a-chip with a robust learning kernel is developed for such a vital clinical need.

Original language	English
Title of host publication	2014 IEEE International Solid-State Circuits Conference, ISSCC 2014 - Digest of Technical Papers
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	420-421
Number of pages	2
ISBN (Print)	9781479909186
DOIs	https://doi.org/10.1109/ISSCC.2014.6757496
Publication status	Published - 2014
Event	2014 61st IEEE International Solid-State Circuits Conference, ISSCC 2014 - San Francisco, CA, United States Duration: Feb 9 2014 → Feb 13 2014

Publication series

Name	Digest of Technical Papers - IEEE International Solid-State Circuits Conference
Volume	57
ISSN (Print)	0193-6530

Other

Other	2014 61st IEEE International Solid-State Circuits Conference, ISSCC 2014
Country/Territory	United States
City	San Francisco, CA
Period	2/9/14 → 2/13/14

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Electrical and Electronic Engineering

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10.1109/ISSCC.2014.6757496

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Tang, K. T., Chiu, S. W., Shih, C.-H., Chang, C. L., Yang, C. M., Yao, D. J., Wang, J. H., Huang, C. M., Chen, H., Chang, K. H., Hsieh, C. C., Chang, T. H., Chang, M. F., Wang, C. M., Liu, Y. W., Chen, T. J., Yang, C. H., Chiueh, H., & Shyu, J. M. (2014). A 0.5V 1.27mW nose-on-a-chip for rapid diagnosis of ventilator-associated pneumonia. In 2014 IEEE International Solid-State Circuits Conference, ISSCC 2014 - Digest of Technical Papers (pp. 420-421). Article 6757496 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; Vol. 57). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ISSCC.2014.6757496

A 0.5V 1.27mW nose-on-a-chip for rapid diagnosis of ventilator-associated pneumonia. / Tang, Kea Tiong; Chiu, Shih Wen; Shih, Chung-Hung et al.
2014 IEEE International Solid-State Circuits Conference, ISSCC 2014 - Digest of Technical Papers. Institute of Electrical and Electronics Engineers Inc., 2014. p. 420-421 6757496 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; Vol. 57).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Tang, KT, Chiu, SW, Shih, C-H, Chang, CL, Yang, CM, Yao, DJ, Wang, JH, Huang, CM, Chen, H, Chang, KH, Hsieh, CC, Chang, TH, Chang, MF, Wang, CM, Liu, YW, Chen, TJ, Yang, CH, Chiueh, H & Shyu, JM 2014, A 0.5V 1.27mW nose-on-a-chip for rapid diagnosis of ventilator-associated pneumonia. in 2014 IEEE International Solid-State Circuits Conference, ISSCC 2014 - Digest of Technical Papers., 6757496, Digest of Technical Papers - IEEE International Solid-State Circuits Conference, vol. 57, Institute of Electrical and Electronics Engineers Inc., pp. 420-421, 2014 61st IEEE International Solid-State Circuits Conference, ISSCC 2014, San Francisco, CA, United States, 2/9/14. https://doi.org/10.1109/ISSCC.2014.6757496

Tang KT, Chiu SW, Shih CH, Chang CL, Yang CM, Yao DJ et al. A 0.5V 1.27mW nose-on-a-chip for rapid diagnosis of ventilator-associated pneumonia. In 2014 IEEE International Solid-State Circuits Conference, ISSCC 2014 - Digest of Technical Papers. Institute of Electrical and Electronics Engineers Inc. 2014. p. 420-421. 6757496. (Digest of Technical Papers - IEEE International Solid-State Circuits Conference). doi: 10.1109/ISSCC.2014.6757496

Tang, Kea Tiong ; Chiu, Shih Wen ; Shih, Chung-Hung et al. / A 0.5V 1.27mW nose-on-a-chip for rapid diagnosis of ventilator-associated pneumonia. 2014 IEEE International Solid-State Circuits Conference, ISSCC 2014 - Digest of Technical Papers. Institute of Electrical and Electronics Engineers Inc., 2014. pp. 420-421 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference).

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abstract = "Ventilator-associated pneumonia (VAP) is the most frequently acquired infection among patients that receive mechanical ventilation in the intensive-care unit (ICU). The mortality rate for VAP lies in the 20-to-50% range and could be even higher in some ICUs. A standard operation procedure to VAP treatment includes a sequence of chest radiography, sputum gram stain, sputum culture, and empiric therapy, initially with antibiotics covering broad pathogens. However, collection of the gram stain and culture of lower respiratory tract specimen is usually not time-efficient (up to 5 days), delaying the initiation of therapy and unacceptable for critically ill patients. A rapid and accurate diagnosis for VAP is therefore crucial, but still unavailable. It is known that microorganisms generate complex metabolites during infection. Fast detection is feasible by examining metabolic wastes in proximal end of the expiratory device, demanding a miniaturized, battery-powered, gas-sensing device. In this work, a fully integrated low-power nose-on-a-chip with a robust learning kernel is developed for such a vital clinical need.",

author = "Tang, {Kea Tiong} and Chiu, {Shih Wen} and Chung-Hung Shih and Chang, {Chia Ling} and Yang, {Chia Min} and Yao, {Da Jeng} and Wang, {Jen Huo} and Huang, {Chien Ming} and Hsin Chen and Chang, {Kwuang Han} and Hsieh, {Chih Cheng} and Chang, {Ting Hau} and Chang, {Meng Fan} and Wang, {Chia Min} and Liu, {Yi Wen} and Chen, {Tsan Jieh} and Yang, {Chia Hsiang} and Herming Chiueh and Shyu, {Jyuo Min}",

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AU - Chang, Chia Ling

AU - Yang, Chia Min

AU - Yao, Da Jeng

AU - Wang, Jen Huo

AU - Huang, Chien Ming

AU - Chen, Hsin

AU - Chang, Kwuang Han

AU - Hsieh, Chih Cheng

AU - Chang, Ting Hau

AU - Chang, Meng Fan

AU - Wang, Chia Min

AU - Liu, Yi Wen

AU - Chen, Tsan Jieh

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AU - Chiueh, Herming

AU - Shyu, Jyuo Min

PY - 2014

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N2 - Ventilator-associated pneumonia (VAP) is the most frequently acquired infection among patients that receive mechanical ventilation in the intensive-care unit (ICU). The mortality rate for VAP lies in the 20-to-50% range and could be even higher in some ICUs. A standard operation procedure to VAP treatment includes a sequence of chest radiography, sputum gram stain, sputum culture, and empiric therapy, initially with antibiotics covering broad pathogens. However, collection of the gram stain and culture of lower respiratory tract specimen is usually not time-efficient (up to 5 days), delaying the initiation of therapy and unacceptable for critically ill patients. A rapid and accurate diagnosis for VAP is therefore crucial, but still unavailable. It is known that microorganisms generate complex metabolites during infection. Fast detection is feasible by examining metabolic wastes in proximal end of the expiratory device, demanding a miniaturized, battery-powered, gas-sensing device. In this work, a fully integrated low-power nose-on-a-chip with a robust learning kernel is developed for such a vital clinical need.

AB - Ventilator-associated pneumonia (VAP) is the most frequently acquired infection among patients that receive mechanical ventilation in the intensive-care unit (ICU). The mortality rate for VAP lies in the 20-to-50% range and could be even higher in some ICUs. A standard operation procedure to VAP treatment includes a sequence of chest radiography, sputum gram stain, sputum culture, and empiric therapy, initially with antibiotics covering broad pathogens. However, collection of the gram stain and culture of lower respiratory tract specimen is usually not time-efficient (up to 5 days), delaying the initiation of therapy and unacceptable for critically ill patients. A rapid and accurate diagnosis for VAP is therefore crucial, but still unavailable. It is known that microorganisms generate complex metabolites during infection. Fast detection is feasible by examining metabolic wastes in proximal end of the expiratory device, demanding a miniaturized, battery-powered, gas-sensing device. In this work, a fully integrated low-power nose-on-a-chip with a robust learning kernel is developed for such a vital clinical need.

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ER -

A 0.5V 1.27mW nose-on-a-chip for rapid diagnosis of ventilator-associated pneumonia

Abstract

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