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  Targeting mitochondrial oxphos and their regulatory signals in prostate cancers

  Chen, C. L., Lin, C. Y. & Kung, H. J., Dec 1 2021, In: International journal of molecular sciences. 22, 24, 13435.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  10 Citations (Scopus)

• Targeting myotonic dystrophy by preimplantation genetic diagnosis-karyomapping

  Wang, C. W., Liu, Y. L. & Chen, C. H., Nov 2019, In: Taiwanese Journal of Obstetrics and Gynecology. 58, 6, p. 891-894 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Citations (Scopus)

• Targeting nanoparticle-conjugated microbubbles combined with ultrasound-mediated microbubble destruction for enhanced tumor therapy

  Chen, K. W., Hsu, P. H., Huang, H. L., Liu, H. L., Lin, Y. T., Hsu, C. Y., Lin, J. H. & Lin, Y. H., Dec 2022, In: Pharmacological Research. 186, 106532.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• Targeting neuropilin 1 as an antitumor strategy in lung cancer

  Hong, T. M., Chen, Y. L., Wu, Y. Y., Yuan, A., Chao, Y. C., Chung, Y. C., Wu, M. H., Yang, S. C., Pan, S. H., Shih, J. Y., Chan, W. K. & Yang, P. C., Aug 15 2007, In: Clinical Cancer Research. 13, 16, p. 4759-4768 10 p.

  Research output: Contribution to journal › Article › peer-review
  136 Citations (Scopus)

• Targeting of multiple oncogenic signaling pathways by Hsp90 inhibitor alone or in combination with berberine for treatment of colorectal cancer

  Su, Y-H., Tang, W. C., Cheng, Y. W., Sia, P., Huang, C. C., Lee, Y. C., Jiang, H. Y., Wu, M. H., Lai, I. L., Lee, J. W. & Lee, K. H., Oct 1 2015, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1853, 10, p. 2261-2272 12 p.

  Research output: Contribution to journal › Article › peer-review
  52 Citations (Scopus)

• Targeting of Topoisomerase I for Prognoses and Therapeutics of Camptothecin-Resistant Ovarian Cancer

  Lee, Y. C., Lee, C. H., Tsai, H. P., An, H. W., Lee, C-M., Wu, J. C., Chen, C. S., Huang, S. H., Hwang, J., Cheng, K. T., Leiw, P. L., Chen, C. L. & Lin, C. M., Jul 24 2015, In: PLoS ONE. 10, 7, e0132579.

  Research output: Contribution to journal › Article › peer-review
  26 Citations (Scopus)

• Targeting PKLR/MYCN/ROMO1 signaling suppresses neuroendocrine differentiation of castration-resistant prostate cancer

  Chen, W. Y., Thuy Dung, P. V., Yeh, H. L., Chen, W. H., Jiang, K. C., Li, H. R., Chen, Z. Q., Hsiao, M., Huang, J., Wen, Y. C. & Liu, Y. N., Jun 2023, In: Redox Biology. 62, 102686.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Targeting PML-RARα and oncogenic signaling pathways by Chinese herbal mixture Tien-Hsien liquid in acute promyelocytic leukemia NB4 cells

  Lai, T-I., Yao, C. J., Yang, C. M., Chuang, S. E., Yan, J. L., Liu, C. Y., Chen, S. W., Yan, K. H. & Lai, G. M., 2011, In: Evidence-based Complementary and Alternative Medicine. 2011, 984154.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• Targeting ROS and cPLA2/COX2 Expressions Ameliorated Renal Damage in Obese Mice with Endotoxemia

  Chang, J. F., Yeh, J. C., Ho, C. T., Liu, S. H., Hsieh, C. Y., Wang, T. M., Chang, S. W., Lee, I. T., Huang, K. Y., Wang, J. Y. & Lin, W. N., Sept 6 2019, In: International Journal of Molecular Sciences. 20, 18, 4393.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  13 Citations (Scopus)

• Targeting SHP-1-STAT3 signaling: A promising therapeutic approach for the treatment of cholangiocarcinoma

  Hu, M. H., Chen, L. J., Chen, Y. L., Tsai, M. S., Shiau, C. W., Chao, T. I., Liu, C. Y., Kao, J. H. & Chen, K. F., 2017, In: Oncotarget. 8, 39, p. 65077-65089 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  16 Citations (Scopus)

• Targeting spleen tyrosine kinase-bruton's tyrosine kinase axis for immunologically mediated glomerulonephritis

  Chen, J. S., Chang, L. C., Huang, S. J. & Cheng, C. W., 2014, In: BioMed Research International. 2014, 814869.

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)

• Targeting Src-Hic-5 Signal Cascade for Preventing Migration of Cholangiocarcinoma Cell HuCCT1

  Wu, W. S., Ling, C. H., Lee, M. C., Cheng, C. C., Chen, R. F., Lin, C. F., You, R. I. & Chen, Y. C., May 2022, In: Biomedicines. 10, 5, 1022.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  3 Citations (Scopus)

• Targeting the CXCR4/CXCL12 axis in treating epithelial ovarian cancer

  Mao, T. L., Fan, K. F. & Liu, C. L., Oct 1 2017, In: Gene Therapy. 24, 10, p. 621-629 9 p.

  Research output: Contribution to journal › Article › peer-review
  40 Citations (Scopus)

• Targeting the delivery of glycan-based paclitaxel prodrugs to cancer cells via glucose transporters

  Lin, Y. S., Tungpradit, R., Sinchaikul, S., An, F. M., Liu, D. Z., Phutrakul, S. & Chen, S. T., Dec 11 2008, In: Journal of Medicinal Chemistry. 51, 23, p. 7428-7441 14 p.

  Research output: Contribution to journal › Article › peer-review
  90 Citations (Scopus)

• Targeting the Epigenetic Non-Coding RNA MALAT1/Wnt Signaling Axis as a Therapeutic Approach to Suppress Stemness and Metastasis in Hepatocellular Carcinoma

  Chang, H. L., Bamodu, O. A., Ong, J. R., Lee, W. H., Yeh, C. T. & Tsai, J. T., Apr 20 2020, In: Cells. 9, 4

  Research output: Contribution to journal › Article › peer-review

  Open Access
  22 Citations (Scopus)

• Targeting the histone demethylase PHF8-mediated PKCα-Src-PTEN axis in HER2-negative gastric cancer

  Tseng, L. L., Cheng, H. H., Yeh, T. S., Huang, S. C., Syu, Y. Y., Chuu, C. P., Yuh, C. H., Kung, H. J. & Wang, W. C., Oct 6 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 40, p. 24859-24866 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  13 Citations (Scopus)

• Targeting therapeutic agent against C3b/C4b, SB002, on the inflammation-induced bone loss in experimental periodontitis

  Huang, R. Y., Tseng, F. Y., You, J. J., Van Dyke, T. E., Cheng, C. D., Sung, C. E., Weng, P. W., Shieh, Y. S. & Cheng, W. C., 2023, (Accepted/In press) In: Journal of Clinical Periodontology. 50, 5, p. 657-670 14 p.

  Research output: Contribution to journal › Article › peer-review

• Targeting therapy for breast carcinoma by ATP synthase inhibitor aurovertin b

  Huang, T. C., Chang, H. Y., Hsu, C. H., Kuo, W. H., Chang, K. J. & Juan, H. F., Apr 2008, In: Journal of Proteome Research. 7, 4, p. 1433-1444 12 p.

  Research output: Contribution to journal › Article › peer-review
  93 Citations (Scopus)

• Targeting the SPOCK1-snail/slug axis-mediated epithelial-to-mesenchymal transition by apigenin contributes to repression of prostate cancer metastasis

  Chien, M. H., Lin, Y. W., Wen, Y. C., Yang, Y. C., Hsiao, M., Chang, J. L., Huang, H. C. & Lee, W. J., Jun 10 2019, In: Journal of Experimental and Clinical Cancer Research. 38, 1, p. 246 246.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  44 Citations (Scopus)

• Targeting the SREBP-1/Hsa-Mir-497/SCAP/FASN Oncometabolic Axis Inhibits the Cancer Stem-Like and Chemoresistant Phenotype of Non-Small Cell Lung Carcinoma Cells

  Tiong, T. Y., Weng, P. W., Wang, C. H., Setiawan, S. A., Yadav, V. K., Pikatan, N. W., Fong, I. H., Yeh, C. T., Hsu, C. H. & Kuo, K. T., Jul 1 2022, In: International journal of molecular sciences. 23, 13, 7283.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Citations (Scopus)

• Targeting the XIAP/caspase-7 complex selectively kills caspase-3-deficient malignancies

  Lin, Y-F., Lai, T. C., Chang, C. K., Chen, C. L., Huang, M. S., Yang, C. J., Liu, H. G., Dong, J. J., Chou, Y. A., Teng, K. H., Chen, S. H., Tian, W. T., Jan, Y. H., Hsiao, M. & Liang, P. H., Sept 3 2013, In: Journal of Clinical Investigation. 123, 9, p. 3861-3875 15 p.

  Research output: Contribution to journal › Article › peer-review
  21 Citations (Scopus)

• Targeting to overexpressed glucose-regulated protein 78 in gastric cancer discovered by 2D DIGE improves the diagnostic and therapeutic efficacy of micelles-mediated system

  Cheng, C. C., Lu, N., Peng, C. L., Chang, C. C., Mai, F. D., Chen, L. Y., Liao, M. H., Wang, W. M. & Chang, J., Aug 2012, In: Proteomics. 12, 15-16, p. 2584-2597 14 p.

  Research output: Contribution to journal › Article › peer-review
  16 Citations (Scopus)

• Targeting TYRO3 inhibits epithelial-mesenchymal transition and increases drug sensitivity in colon cancer

  Chien, C-W., Hou, P-C., Wu, H-C., Chang, Y-L., Lin, S-C., Lin, S-C., Lin, B-W., Lee, J-C., Chang, Y-J., Sun, H. S. & Tsai, S-J., Nov 10 2016, In: Oncogene. 35, 45, p. 5872-5881 10 p.

  Research output: Contribution to journal › Article › peer-review
  52 Citations (Scopus)

• Targeting Tyrosine Kinases and Autophagy in Prostate Cancer

  Kung, H. J., Feb 1 2011, In: Hormones and Cancer. 2, 1, p. 38-46 9 p.

  Research output: Contribution to journal › Article › peer-review
  34 Citations (Scopus)

• Targeting β-tubulin: CCT-β complexes incurs Hsp90- and VCP-related protein degradation and induces ER stress-associated apoptosis by triggering capacitative Ca²⁺ entry, mitochondrial perturbation and caspase overactivation

  Lin, Y-F., Lee, Y. F. & Liang, P. H., Nov 2012, In: Cell Death and Disease. 3, 11, e434.

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• Tartrate-Resistant Acid Phosphatase 5a Activity as a Novel Biomarker for Flare of Systemic Lupus Erythematosus

  Chen, J. H., Wu, Y. Y., Huang, T. C., Lu, C. C., Liu, F. C., Janckila, A. J. & Chao, T-Y., Feb 2017, In: Academia Journal of Biotechnology. 5, 2, 6 p.

  Research output: Contribution to journal › Article › peer-review

• Tartrate-resistant acid phosphatase 5a in sarcoidosis: Further evidence for a novel macrophage biomarker in chronic inflammation

  Wu, Y. Y., Janckila, A. J., Slone, S. P., Perng, W. C. & Chao, T. Y., 2014, In: Journal of the Formosan Medical Association = Taiwan yi zhi. 113, 6, p. 364-370 7 p.

  Research output: Contribution to journal › Article › peer-review
  14 Citations (Scopus)

• Tartrate-resistant acid phosphatase 5b activity is a useful bone marker for monitoring bone metastases in breast cancer patients after treatment

  Chung, Y. C., Ku, C. H., Chao, T. Y., Yu, J. C., Chen, M. M. & Lee, S. H., Mar 2006, In: Cancer Epidemiology Biomarkers and Prevention. 15, 3, p. 424-428 5 p.

  Research output: Contribution to journal › Article › peer-review
  28 Citations (Scopus)

• Tartrate-resistant acid phosphatase 5b as a serum marker of bone metastasis in breast cancer patients

  Chao, T. Y., Ho, C. L., Lee, S. H., Chen, M. M. J., Janckila, A. & Yam, L. T., 2004, In: Journal of Biomedical Science. 11, 4, p. 511-516 6 p.

  Research output: Contribution to journal › Article › peer-review
  25 Citations (Scopus)

• Tartrate-resistant acid phosphatase 5b is a useful serum marker for extensive bone metastasis in breast cancer patients

  Chao, T. Y., Yu, J. C., Ku, C. H., Chen, M. M., Lee, S. H., Janckila, A. J. & Yam, L. T., Jan 15 2005, In: Clinical Cancer Research. 11, 2 I, p. 544-550 7 p.

  Research output: Contribution to journal › Article › peer-review
  52 Citations (Scopus)

• Task-related functional magnetic resonance imaging-based neuronavigation for the treatment of depression by individualized repetitive transcranial magnetic stimulation of the visual cortex

  Zhang, Z., Zhang, H., Xie, C. M., Zhang, M., Shi, Y., Song, R., Lu, X., Zhang, H., Li, K., Wang, B., Yang, Y., Li, X., Zhu, J., Zhao, Y., Yuan, T. F. & Northoff, G., Jan 2021, In: Science China Life Sciences. 64, 1, p. 96-106 11 p.

  Research output: Contribution to journal › Article › peer-review
  16 Citations (Scopus)

• Taurine supplementation improves the utilization of sulfur-containing amino acids in rats continually administrated alcohol

  Yang, H. T., Chien, Y. W., Tsen, J. H., Chang, C. C., Chang, J. H. & Huang, S. Y., Feb 2009, In: Journal of Nutritional Biochemistry. 20, 2, p. 132-139 8 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• Taxifolin resensitizes multidrug resistance cancer cells via uncompetitive inhibition of P-glycoprotein function

  Chen, H. J., Chung, Y. L., Li, C. Y., Chang, Y. T., Wang, C. C. N., Lee, H. Y., Lin, H. Y. & Hung, C. C., Nov 2018, In: Molecules. 23, 12, 3055.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  27 Citations (Scopus)

• Taxol-induced p34(cdc2) kinase activation and apoptosis inhibited by 12- O-Tetradecanoylphorbol-13-acetate in human breast MCF-7 carcinoma cells

  Shen, S. C., Huang, T. S., Jee, S. H. & Kuo, M. L., 1998, In: Cell Growth and Differentiation. 9, 1, p. 23-29 7 p.

  Research output: Contribution to journal › Article › peer-review
  15 Citations (Scopus)

• TB or TB plus vasculitis: Occam versus Hickam [2] (multiple letters)

  Agarwal, R., Gupta, D., Chen, H. A., Liao, H. T. & Huang, D. F., Dec 2005, In: Journal of Internal Medicine. 258, 6, p. 581-583 3 p.

  Research output: Contribution to journal › Article › peer-review

• Tc17 CD8 T cells: Functional plasticity and subset diversity

  Yen, H. R., Harris, T. J., Wada, S., Grosso, J. F., Getnet, D., Goldberg, M. V., Liang, K. L., Bruno, T. C., Pyle, K. J., Chan, S. L., Anders, R. A., Trimble, C. L., Adler, A. J., Lin, T. Y., Pardoll, D. M., Huang, C. T. & Drake, C. G., Dec 1 2009, In: Journal of Immunology. 183, 11, p. 7161-7168 8 p.

  Research output: Contribution to journal › Article › peer-review
  160 Citations (Scopus)

• Tc-99m-HL91 imaging in the early detection of neuronal injury in a neonatal rat model of hypoxic ischemia

  Lee, B. F., Wang, L. W., Lin, S. H., Jhuo, T. J., Chiu, N. T., Huang, C. C., Hsia, C. C. & Shen, L. H., Jun 2012, In: Critical Care Medicine. 40, 6, p. 1930-1938 9 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• Tc-99m HMPAO brain SPECT Imaging in children with acute cerebellar ataxia

  Hung, P. L., Huang, S. H., Huang, C. C., Huang, S. C. & Chang, Y. C., Dec 2008, In: Clinical Nuclear Medicine. 33, 12, p. 841-844 4 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• Tc-99m imaging in thyroidectomized differentiated thyroid cancer patients immediately before I-131 treatment

  Tsai, C. J., Cheng, C. Y., Shen, D. H. Y., Kuo, S. J., Wang, L. Y., Lee, C. H., Wang, J. J., Chang, M. C. & Huang, W. S., 2016, In: Nuclear Medicine Communications. 37, 2, p. 182-187 6 p.

  Research output: Contribution to journal › Article › peer-review
  9 Citations (Scopus)

• Tc-99m MIBI SPECT in detecting metastatic papillary thyroid carcinoma in patients with elevated human serum thyroglobulin levels but negative I-131 whole body scan

  Hsu, C-H., Liu, F. Y., Yen, R. F. & Kao, C. H., 2003, In: Endocrine Research. 29, 1, p. 9-15 7 p.

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• Tc-99m TRODAT-1 SPECT is a potential biomarker for restless leg syndrome in patients with end-stage

  Hou, Y. C., Fan, Y. M., Huang, Y. C., Chen, R. M., Wang, C. H., Lin, Y. T., Yen, T. H., Lu, K. C. & Lin, Y. F., Mar 2020, In: Journal of Clinical Medicine. 9, 3, 889.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Citations (Scopus)

• TcaR-ssDNA complex crystal structure reveals new DNA binding mechanism of the MarR family proteins

  Chang, Y. M., Ho, C. H., Chen, C. K. M., Maestre-Reyna, M., Chang-Chien, M. W. & Wang, A. H. J., Apr 2014, In: Nucleic Acids Research. 42, 8, p. 5314-5321 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  8 Citations (Scopus)

• TCDD induces the hypoxia-inducible factor (HIF)-1α regulatory pathway in human trophoblastic JAR cells

  Liao, T. L., Chen, S. C., Tzeng, C. R. & Kao, S. H., Sept 30 2014, In: International journal of molecular sciences. 15, 10, p. 17733-17750 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  16 Citations (Scopus)

• TCDD promotes lung tumors via attenuation of apoptosis through activation of the Akt and ERK1/2 signaling pathways

  Chen, R. J., Siao, S. H., Hsu, C. H., Chang, C. Y., Chang, L. W., Wu, C. H., Lin, P. & Wang, Y. J., Jun 13 2014, In: PLoS One. 9, 6, e99586.

  Research output: Contribution to journal › Article › peer-review
  15 Citations (Scopus)

• T-cell lymphoblastic lymphoma with eosinophilia associated with subsequent myeloid malignancy

  Abruzzo, L. V., Jaffe, E. S., Cotelingam, J. D., Whang-Peng, J., Del Duca, V. & Medeiros, L. J., Jan 1 1992, In: American Journal of Surgical Pathology. 16, 3, p. 236-245 10 p.

  Research output: Contribution to journal › Article › peer-review
  105 Citations (Scopus)

• T-cell lymphoma in the eyelid following intestinal B-cell lymphona [8]

  Kau, H. C., Ho, H. C., Kao, S. C., Yang, C. F., Hsu, W. M. & Tsai, C. C., Nov 2002, In: Eye. 16, 6, p. 794-796 3 p.

  Research output: Contribution to journal › Article › peer-review
  2 Citations (Scopus)

• TCF7 is suppressed by the androgen receptor via microRNA-1-mediated downregulation and is involved in the development of resistance to androgen deprivation in prostate cancer

  Siu, M. K., Chen, W-Y., Tsai, H-Y., Chen, H-Y., Yin, J. J., Chen, C-L., Tsai, Y-C. & Liu, Y-N., Jun 2017, In: Prostate Cancer and Prostatic Diseases. 20, 2, p. 172-178 7 p.

  Research output: Contribution to journal › Article › peer-review
  21 Citations (Scopus)

• TCF7L1 regulates cytokine response and neuroendocrine differentiation of prostate cancer

  Wen, Y. C., Liu, Y. N., Yeh, H. L., Chen, W. H., Jiang, K. C., Lin, S. R., Huang, J., Hsiao, M. & Chen, W. Y., Nov 2021, In: Oncogenesis. 10, 11, 81.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Citations (Scopus)

• TC-N19, a novel dual inhibitor of EGFR and cMET, efficiently overcomes EGFR-TKI resistance in non-small-cell lung cancer cells

  Wu, D. W., Chen, T. C., Huang, H. S. & Lee, H., Jun 30 2016, In: Cell death & disease. 7, 6, p. e2290

  Research output: Contribution to journal › Article › peer-review
  27 Citations (Scopus)

• TDAG8 deficiency reduces satellite glial number and pro-inflammatory macrophage number to relieve rheumatoid arthritis disease severity and chronic pain

  Dai, S. P., Hsieh, W. S., Chen, C. H., Lu, Y. H., Huang, H. S., Chang, D. M., Huang, S. L. & Sun, W. H., May 29 2020, In: Journal of Neuroinflammation. 17, 1, 170.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  11 Citations (Scopus)