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  Targeted concurrent and sequential delivery of chemotherapeutic and antiangiogenic agents to the brain by using drug-loaded nanofibrous membranes

  Tseng, Y. Y., Yang, T. C., Wang, Y. C., Lee, W. H., Chang, T. M., Kau, Y. C. & Liu, S. J., Feb 14 2017, In: International Journal of Nanomedicine. 12, p. 1265-1276 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  17 Citations (Scopus)

• Targeted Covalent Inhibitors Allosterically Deactivate the DEDDh Lassa Fever Virus NP Exonuclease from Alternative Distal Sites

  Huang, K. W., Chen, J. W., Hua, T. Y., Chu, Y. Y., Chiu, T. Y., Liu, J. Y., Tu, C. I., Hsu, K. C., Kao, Y. T., Chu, J. W. & Hsiao, Y. Y., Dec 27 2021, In: Journal of the American Chemical Society. 1, 12, p. 2315-2327 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Citation (Scopus)

• Targeted delivery of cisplatin to tumor xenografts via the nanoparticle component of nano-diamino-tetrac

  Sudha, T., Bharali, D. J., Yalcin, M., Darwish, N. H. E., Coskun, M. D., Keating, K. A., Lin, H. Y., Davis, P. J. & Mousa, S. A., Feb 2017, In: Nanomedicine. 12, 3, p. 195-205 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  32 Citations (Scopus)

• Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac

  Sudha, T., Bharali, D. J., Yalcin, M., Darwish, N. H. E., Coskun, M. D., Keating, K. A., Lin, H. Y., Davis, P. J. & Mousa, S. A., Feb 15 2017, In: International Journal of Nanomedicine. 12, p. 1305-1315 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  36 Citations (Scopus)

• Targeted delivery system for juxtacrine signaling growth factor based on rhBMP-2-mediated carrier-protein conjugation

  Liu, H. W., Chen, C. H., Tsai, C. L. & Hsiue, G. H., Oct 2006, In: Bone. 39, 4, p. 825-836 12 p.

  Research output: Contribution to journal › Article › peer-review
  41 Citations (Scopus)

• Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice

  Wu, L. S., Cheng, W. C. & Shen, C. K. J., Aug 10 2012, In: Journal of Biological Chemistry. 287, 33, p. 27335-27344 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  116 Citations (Scopus)

• Targeted Disruption in Mice of a Neural Stem Cell-Maintaining, KRAB-Zn Finger-Encoding Gene That Has Rapidly Evolved in the Human Lineage

  Chien, H. C., Wang, H. Y., Su, Y. N., Lai, K. Y., Lu, L. C., Chen, P. C., Tsai, S. F., Wu, C. I., Hsieh, W. S. & Shen, C. K. J., Oct 10 2012, In: PLoS ONE. 7, 10, e47481.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  11 Citations (Scopus)

• Targeted disruption of nebulette protein expression alters cardiac myofibril assembly and function

  Moncman, C. L. & Wang, K., 2002, In: Experimental Cell Research. 273, 2, p. 204-218 15 p.

  Research output: Contribution to journal › Article › peer-review
  28 Citations (Scopus)

• Targeted gene delivery to alveolar macrophages via Fc receptor-mediated endocytosis

  Rojanasakul, Y., Wang, L. Y., Malanga, C. J., Ma, J. K. H. & Liaw, J., 1994, In: Pharmaceutical Research. 11, 12, p. 1731-1736 6 p.

  Research output: Contribution to journal › Article › peer-review
  38 Citations (Scopus)

• Targeted mass CPR training for families of cardiac patients - Experience in Taipei city

  Cheng, Y. C., Hu, S. C., Yen, D., Kao, W. F. & Lee, C. H., 1997, In: Tzu Chi Medical Journal. 9, 4, p. 273-278 6 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• Targeted methylation of CMV and E1A viral promoters

  Hsu, C. C., Li, H. P., Hung, Y. H., Leu, Y. W., Wu, W. H., Wang, F. S., Lee, K. D., Chang, P. J., Wu, C. S., Lu, Y. J., Huang, T. H. M., Chang, Y. S. & Hsiao, S. H., Nov 12 2010, In: Biochemical and Biophysical Research Communications. 402, 2, p. 228-234 7 p.

  Research output: Contribution to journal › Article › peer-review
  59 Citations (Scopus)

• Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells

  Teng, I. W., Hou, P. C., Lee, K. D., Chu, P. Y., Yeh, K. T., Jin, V. X., Tseng, M. J., Tsai, S. J., Chang, Y. S., Wu, C. S., Sun, H. S., Tsai, K. D., Jeng, L. B., Nephew, K. P., Huang, T. H. M., Hsiao, S. H. & Leu, Y. W., Jul 1 2011, In: Cancer Research. 71, 13, p. 4653-4663 11 p.

  Research output: Contribution to journal › Article › peer-review
  87 Citations (Scopus)

• Targeted next-generation sequencing for genetic variants of left ventricular mass status among community-based adults in Taiwan

  Fan, H. Y., Lin, W. Y., Lu, T. P., Chen, Y. Y., Hsu, J. B. K., Yu, S. L., Su, T. C., Lin, H. J., Chen, Y. C. & Chien, K. L., Jan 12 2023, In: Frontiers in Genetics. 13, 1064980.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Targeted Next-generation Sequencing Reveals a Wide Morphologic and Immunophenotypic Spectrum of Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma

  Hang, J. F., Yuan, C. T., Chang, K. C., Wang, R. C., Chen, B. J., Hsieh, P. P., Huang, W. T., Chuang, W. Y., Chen, T. W., Yeh, Y. C., Lin, S. Y., Hsiao, C. H., Chou, S. C., Tseng, C. E., Pan, S. T., Chang, S. L. & Chuang, S. S., Sept 1 2022, In: American Journal of Surgical Pathology. 46, 9, p. 1207-1218 12 p.

  Research output: Contribution to journal › Article › peer-review
  2 Citations (Scopus)

• Targeted PARP Inhibition Combined with FGFR1 Blockade is Synthetically Lethal to Malignant Cells in Patients with Pancreatic Cancer

  Lai, S. W., Bamodu, O. A., Chen, J. H., Wu, A. T., Lee, W. H., Chao, T. Y. & Yeh, C. T., Apr 8 2020, In: Cells. 9, 4

  Research output: Contribution to journal › Article › peer-review

  Open Access
  6 Citations (Scopus)

• Targeted treatment of primary aldosteronism – The consensus of Taiwan Society of Aldosteronism

  TAIPAI, Taiwan Primary Aldosteronism Investigator, Jan 2019, In: Journal of the Formosan Medical Association. 118, 1P1, p. 72-82 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  14 Citations (Scopus)

• Targeting annexin A2 reduces tumorigenesis and therapeutic resistance of nasopharyngeal carcinoma

  Chen, C. Y., Lin, Y-S., Chen, C. L., Chao, P. Z., Chiou, J. F., Kuo, C. C., Lee, F. P., Lin, Y. F., Sung, Y. H., Lin, Y. T., Li, C. F., Chen, Y. J. & Chen, C. H., 2015, In: Oncotarget. 6, 29, p. 26946-26959 14 p.

  Research output: Contribution to journal › Article › peer-review
  35 Citations (Scopus)

• Targeting Autophagy Augments BBR-Mediated Cell Death in Human Hepatoma Cells Harboring Hepatitis C Virus RNA

  Tai, C. J., Jassey, A., Liu, C. H., Tai, C. J., Richardson, C. D., Wong, S. H. & Lin, L. T., Apr 8 2020, In: Cells. 9, 4

  Research output: Contribution to journal › Article › peer-review

  Open Access
  11 Citations (Scopus)

• Targeting autophagy by MPT0L145, a highly potent pik3c3 inhibitor, provides synergistic interaction to targeted or chemotherapeutic agents in cancer cells

  Chen, C. H., Hsieh, T. H., Lin, Y. C., Liu, Y. R., Liou, J. P. & Yen, Y., Sept 2019, In: Cancers. 11, 9, 1345.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  11 Citations (Scopus)

• Targeting autophagy overcomes Enzalutamide resistance in castration-resistant prostate cancer cells and improves therapeutic response in a xenograft model

  Nguyen, H. G., Yang, J. C., Kung, H. J., Shi, X. B., Tilki, D., Lara, P. N., Devere White, R. W., Gao, A. C. & Evans, C. P., Sept 4 2014, In: Oncogene. 33, 36, p. 4521-4530 10 p.

  Research output: Contribution to journal › Article › peer-review
  121 Citations (Scopus)

• Targeting BC200/miR218-5p Signaling Axis for Overcoming Temozolomide Resistance and Suppressing Glioma Stemness

  Su, Y. K., Lin, J. W., Shih, J. W., Chuang, H. Y., Fong, I. H., Yeh, C-T. & Lin, C-M., Aug 8 2020, In: Cells. 9, 8

  Research output: Contribution to journal › Article › peer-review

  Open Access
  13 Citations (Scopus)

• Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor

  Guo, W., Liu, R., Bhardwaj, G., Yang, J. C., Changou, C., Ma, A. H., Mazloom, A., Chintapalli, S., Xiao, K., Xiao, W., Kumaresan, P., Sanchez, E., Yeh, C. T., Evans, C. P., Patterson, R., Lam, K. S. & Kung, H. J., Jan 1 2014, In: Cell Death and Disease. 5, 9, e1409.

  Research output: Contribution to journal › Article › peer-review
  34 Citations (Scopus)

• Targeting cancer initiating cells by promoting cell differentiation and restoring chemosensitivity via dual inactivation of STAT3 and src activity using an active component of antrodia cinnamomea mycelia

  Chang, C. W., Chen, Y. S., Chen, C. C., Chan, I. O., Chen, C. C., Sheu, S. J., Lin, T. W., Chou, S. H., Liu, C. J., Lee, T. C. & Lo, J. F., 2016, In: Oncotarget. 7, 45, p. 73016-73031 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  14 Citations (Scopus)

• Targeting cancer stem cells in breast cancer: Potential anticancer properties of 6-shogaol and pterostilbene

  Wu, C. H., Hong, B. H., Ho, C. T. & Yen, G. C., 2015, In: Journal of Agricultural and Food Chemistry. 63, 9, p. 2432-2441 10 p.

  Research output: Contribution to journal › Article › peer-review
  67 Citations (Scopus)

• Targeting Castration-Resistant Prostate Cancer Using Mesenchymal Stem Cell Exosomes for Therapeutic MicroRNA-let-7c Delivery

  Kurniawati, I., Liu, M. C., Hsieh, C. L., Do, A. D. & Sung, S. Y., Sept 2022, In: Frontiers in Bioscience - Landmark. 27, 9, 256.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  3 Citations (Scopus)

• Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway

  Chen, K. L., Chang, W. S. W., Cheung, C. H. A., Lin, C. C., Huang, C. C., Yang, Y. N., Kuo, C. P., Kuo, C. C., Chang, Y. H., Liu, K. J., Wu, C. M. & Chang, J. Y., Apr 2012, In: Cancer Letters. 317, 1, p. 89-98 10 p.

  Research output: Contribution to journal › Article › peer-review
  59 Citations (Scopus)

• Targeting chemotherapy-induced PTX3 in tumor stroma to prevent the progression of drug-resistant cancers

  Chi, J. Y., Hsiao, Y. W., Li, C. F., Lo, Y. C., Lin, Z. Y., Hong, J. Y., Liu, Y. M., Han, X., Wang, S. M., Chen, B. K., Tsai, K-C. & Wang, J. M., 2015, In: Oncotarget. 6, 27, p. 23987-24001 15 p.

  Research output: Contribution to journal › Article › peer-review
  43 Citations (Scopus)

• Targeting c-Myc as a novel approach for hepatocellular carcinoma

  Lin, C. P., Liu, C. R., Lee, C. N., Chan, T. S. & Liu, H. E., 2010, In: World Journal of Hepatology. 2, 1, p. 16-20 5 p.

  Research output: Contribution to journal › Article › peer-review
  105 Citations (Scopus)

• Targeting constitutively activated β1 integrins inhibits prostate cancer metastasis

  Lee, Y. C., Jin, J. K., Cheng, C. J., Huang, C. F., Song, J. H., Huang, M., Brown, W. S., Zhang, S., Yu-Lee, L. Y., Yeh, E. T., McIntyre, B. W., Logothetis, C. J., Gallick, G. E. & Lin, S. H., Apr 2013, In: Molecular Cancer Research. 11, 4, p. 405-417 13 p.

  Research output: Contribution to journal › Article › peer-review
  73 Citations (Scopus)

• Targeting DRD2 by the antipsychotic drug, penfluridol, retards growth of renal cell carcinoma via inducing stemness inhibition and autophagy-mediated apoptosis

  Tung, M. C., Lin, Y. W., Lee, W. J., Wen, Y. C., Liu, Y. C., Chen, J. Q., Hsiao, M., Yang, Y. C. & Chien, M. H., Apr 2022, In: Cell Death and Disease. 13, 4, 400.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  4 Citations (Scopus)

• Targeting ECM-integrin interaction with liposome-encapsulated small interfering RNAs inhibits the growth of human prostate cancer in a bone xenograft imaging model

  Bisanz, K., Yu, J., Edlund, M., Spohn, B., Hung, M. C., Chung, L. W. K. & Hsieh, C. L., Oct 2005, In: Molecular Therapy. 12, 4, p. 634-643 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  40 Citations (Scopus)

• Targeting efficiency and biodistribution of biotinylated-EGF-conjugated gelatin nanoparticles administered via aerosol delivery in nude mice with lung cancer

  Tseng, C. L., Wu, S. Y. H., Wang, W. H., Peng, C. L., Lin, F. H., Lin, C. C., Young, T. H. & Shieh, M. J., Jul 2008, In: Biomaterials. 29, 20, p. 3014-3022 9 p.

  Research output: Contribution to journal › Article › peer-review
  131 Citations (Scopus)

• Targeting endothelium-pericyte cross talk by inhibiting VEGF receptor signaling attenuates kidney microvascular rarefaction and fibrosis

  Lin, S. L., Chang, F. C., Schrimpf, C., Chen, Y. T., Wu, C. F., Wu, V. C., Chiang, W. C., Kuhnert, F., Kuo, C. J., Chen, Y. M., Wu, K. D., Tsai, T. J. & Duffield, J. S., Feb 2011, In: American Journal of Pathology. 178, 2, p. 911-923 13 p.

  Research output: Contribution to journal › Article › peer-review
  204 Citations (Scopus)

• Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator

  Lee, K. H., Hsu, E. C., Guh, J. H., Yang, H. C., Wang, D., Kulp, S. K., Shapiro, C. L. & Chen, C. S., Nov 11 2011, In: Journal of Biological Chemistry. 286, 45, p. 39247-39258 12 p.

  Research output: Contribution to journal › Article › peer-review
  86 Citations (Scopus)

• Targeting epidermal growth factor receptor in lung cancer: Perspective from the Asia-Pacific region

  Liu, H. E., Lim, K. H., Huang, M. J. & Huang, B. S., Mar 2006, In: Asia-Pacific Journal of Clinical Oncology. 2, 1, p. 22-31 10 p.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• Targeting FAT1 inhibits carcinogenesis, induces oxidative stress and enhances cisplatin sensitivity through deregulation of LRP5/WNT2/GSS signaling axis in oral squamous cell carcinoma

  Hsu, T. N., Huang, C. M., Huang, C. S., Huang, M. S., Yeh, C. T., Chao, T. Y. & Bamodu, O. A., Dec 2019, In: Cancers. 11, 12, 1883.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  18 Citations (Scopus)

• Targeting fibrinogen-like protein 1 is a novel therapeutic strategy to combat obesity

  Wu, H. T., Chen, S. C., Fan, K. C., Kuo, C. H., Lin, S. Y., Wang, S. H., Chang, C. J. & Li, H. Y., Feb 1 2020, In: FASEB Journal. 34, 2, p. 2958-2967 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  20 Citations (Scopus)

• Targeting galectin-1 impairs castration-resistant prostate cancer progression and invasion

  Shih, T-C., Liu, R., Wu, C-T., Li, X., Xiao, W., Deng, X., Kiss, S., Wang, T., Chen, X-J., Carney, R., Kung, H-J., Duan, Y., Ghosh, P. M. & Lam, K. S., 2018, In: Clinical Cancer Research. 24, 17, p. 4319-4331 13 p.

  Research output: Contribution to journal › Article › peer-review
  29 Citations (Scopus)

• Targeting galectin-1 in carcinoma-associated fibroblasts inhibits oral squamous cell carcinoma metastasis by downregulating MCP-1/CCL2 expression

  Wu, M. H., Hong, H. C., Hong, T. M., Chiang, W. F., Jin, Y. T. & Chen, Y. L., Mar 15 2011, In: Clinical Cancer Research. 17, 6, p. 1306-1316 11 p.

  Research output: Contribution to journal › Article › peer-review
  108 Citations (Scopus)

• Targeting glutamine metabolism enhances responses to platinum-based chemotherapy in triple-negative breast cancers (TNBC)

  Hong, J., Shen, Y. A., Hsu, C. Y., Huang, P., Tomaszewski, A., Gabrielson, E., Shih, I. M., Gaillard, S. & Wang, T. L., 2022, (Accepted/In press) In: Genes and Diseases. 9, 6, p. 1408-1411 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Citations (Scopus)

• Targeting heat shock factor 1 as an antiviral strategy against dengue virus replication in vitro and in vivo

  Tsai, T. T., Chen, C. L., Tsai, C. C. & Lin, C. F., Sept 1 2017, In: Antiviral Research. 145, p. 44-53 10 p.

  Research output: Contribution to journal › Article › peer-review
  8 Citations (Scopus)

• Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells

  Cheung, C. H. A., Chen, H. H., Cheng, L. T., Lyu, K. W., Kanwar, J. R. & Chang, J. Y., Apr 2010, In: Molecular Cancer. 9, 77.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  43 Citations (Scopus)

• Targeting inhibitors of apoptosis proteins suppresses medulloblastoma cell proliferation via G2/M phase arrest and attenuated neddylation of p21

  Chen, S. M., Lin, T. K., Tseng, Y. Y., Tu, C. H., Lui, T. N., Huang, S. F., Hsieh, L. L. & Li, Y. Y., Aug 2018, In: Cancer Medicine. 7, 8, p. 3988-4003 16 p.

  Research output: Contribution to journal › Article › peer-review
  9 Citations (Scopus)

• Targeting insulin-like growth factor-binding protein-3 by microRNA-125b promotes tumor invasion and poor outcomes in non-small-cell lung cancer

  Wang, H. H., Wang, Y. C., Wu, D-W., Hung, C. S., Chen, C. Y. & Lee, H., Apr 1 2017, In: Tumor Biology. 39, 4

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• Targeting integrins with RGD-conjugated gold nanoparticles in radiotherapy decreases the invasive activity of breast cancer cells

  Wu, P-H., Onodera, Y., Ichikawa, Y., Rankin, E. B., Giaccia, A. J., Watanabe, Y., Qian, W., Hashimoto, T., Shirato, H. & Nam, J-M., 2017, In: International Journal of Nanomedicine. 12, p. 5069-5085 17 p.

  Research output: Contribution to journal › Article › peer-review
  79 Citations (Scopus)

• Targeting KDM4B that coactivates c-Myc-regulated metabolism to suppress tumor growth in castrationresistant prostate cancer

  Wu, M. J., Chen, C. J., Lin, T. Y., Liu, Y. Y., Tseng, L. L., Cheng, M. L., Chuu, C. P., Tsai, H. K., Kuo, W. L., Kung, H. J. & Wang, W. C., 2021, In: Theranostics. 11, 16, p. 7779-7796 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  13 Citations (Scopus)

• Targeting L1 cell adhesion molecule expression using liposomeencapsulated siRNA suppresses prostate cancer bone metastasis and growth

  Sung, S. Y., Wu, I. H., Chuang, P. H., Petros, J. A., Wu, H. C., Zeng, H. J., Huang, W. C., Chung, L. W. K. & Hsieh, C. L., 2014, In: Oncotarget. 5, 20, p. 9911-9929 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  19 Citations (Scopus)

• Targeting L1 cell adhesion molecule using lentivirus-mediated short hairpin RNA interference reverses aggressiveness of oral squamous cell carcinoma

  Hung, S. C., Wu, I. H., Hsue, S. S., Liao, C. H., Wang, H. C., Chuang, P. H., Sung, S. Y. & Hsieh, C. L., Dec 6 2010, In: Molecular Pharmaceutics. 7, 6, p. 2312-2323 12 p.

  Research output: Contribution to journal › Article › peer-review
  21 Citations (Scopus)

• Targeting LncRNA HOTAIR suppresses cancer stemness and metastasis in oral carcinomas stem cells through modulation of EMT

  Lu, M. Y., Liao, Y. W., Chen, P. Y., Hsieh, P. L., Fang, C. Y., Wu, C. Y., Yen, M. L., Peng, B. Y., Wang, D. P., Cheng, H. C., Wu, C. Z., Shih, Y. H., Wang, D. J., Yu, C. C. & Tsai, L. L., Jan 1 2017, In: Oncotarget. 8, 58, p. 98542-98552 11 p.

  Research output: Contribution to journal › Article › peer-review
  57 Citations (Scopus)

• Targeting Lung–Gut Axis for Regulating Pollution Particle–Mediated Inflammation and Metabolic Disorders

  Cheng, W-L., Chang, C-C., Luo, C-S., Chen, K-Y., Yeh, Y-K., Zheng, J-Q. & Wu, S-M., 2023, In: Cells. 12, 6

  Research output: Contribution to journal › Article › peer-review