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• Discovery of Novel Protein Biomarkers in Urine for Diagnosis of Urothelial Cancer Using iTRAQ Proteomics

  Chen, C. J., Chou, C. Y., Shu, K. H., Chen, H. C., Wang, M. C., Chang, C. C., Hsu, B. G., Wu, M. S., Yang, Y. L., Liao, W. L., Yang, C., Hsiao, Y. T. & Huang, C. C., May 7 2021, In: Journal of Proteome Research. 20, 5, p. 2953-2963 11 p.

  Research output: Contribution to journal › Article › peer-review
  9 Citations (Scopus)

• Discovery of Novel N-Glycoside and Non-Glycoside hSGLT2 Inhibitors for the Treatment of Type 2 Diabetes Mellitus

  Chang, C. Y., Ho, Y., Lin, S-J. & Liu, H. L., Aug 2019, In: International Journal of Diabetes Mellitus.

  Research output: Contribution to journal › Article › peer-review

• Discovery of Novel Microtubule Inhibitors as Potential Anticancer Drugs

  張俊彥(Jang-Yang C, Jun 2005, In: 中華民國癌症醫學會雜誌. 21, 2, p. 25-33 9 p.

  Research output: Contribution to journal › Article › peer-review

• Discovery of Novel Irreversible HER2 Inhibitors for Breast Cancer Treatment

  Tang, J. Y., Ho, Y., Chang, C. Y. & Liu, H. L., Apr 2019, In: Journal of Biomedical Science and Engineering.

  Research output: Contribution to journal › Article › peer-review

• Discovery of novel bladder cancer biomarkers by comparative urine proteomics using iTRAQ technology

  Chen, Y. T., Chen, C. L., Chen, H. W., Chung, T., Wu, C. C., Chen, C. D., Hsu, C. W., Chen, M. C., Tsui, K. H., Chang, P. L., Chang, Y. S. & Yu, J. S., Nov 2010, In: Journal of Proteome Research. 9, 11, p. 5803-5815 13 p.

  Research output: Contribution to journal › Article › peer-review
  124 Citations (Scopus)

• Discovery of novel 5α-reductase type II inhibitors by pharmacophore modelling, virtual screening, molecular docking and molecular dynamics simulations

  Wang, J. L., Liu, H. L., Zhou, Z. L., Chen, W. H. & Ho, Y., Mar 4 2015, In: Molecular Simulation. 41, 4, p. 287-297 11 p.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• Discovery of Natural Veterinary Herbal Medicine Products in Commercial Cow Milk by Using Nontargeted Profiling on LC–ESI–TOF Platform

  Wang, S. Y. & Liao, H. W., Apr 2022, In: Food Analytical Methods.

  Research output: Contribution to journal › Article › peer-review

• Discovery of indeno[1,2-c]quinoline derivatives as potent dual antituberculosis and anti-inflammatory agents

  Tseng, C. H., Tung, C. W., Wu, C. H., Tzeng, C. C., Chen, Y. H., Hwang, T. L. & Chen, Y. L., Jun 1 2017, In: Molecules. 22, 6, 1001.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  26 Citations (Scopus)

• Discovery of HLA-DRB1*03: 20 allele in a Taiwanese volunteer hematopoietic stem cell donor and the probable HLA-A, -B, -C and -DRB1 haplotype in association with DRB1*03:20

  Yang, K. L., Lee, S. K., Yang, S. Y., Kao, R. H., Lin, C. L. & Lin, P. Y., Jun 1 2013, In: International Journal of Immunogenetics. 40, 3, p. 243-245 3 p.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• Discovery of highly potent tyrosinase inhibitor, T1, with significant anti-melanogenesis ability by zebrafish in vivo assay and computational molecular modeling

  Chen, W-C., Tseng, T-S., Hsiao, N-W., Lin, Y-L., Wen, Z-H., Tsai, C-C., Lee, Y-C., Lin, H-H. & Tsai, K-C., 2015, In: Scientific Reports. 5

  Research output: Contribution to journal › Article › peer-review
  116 Citations (Scopus)

• Discovery of genes from feces correlated with colorectal cancer progression

  Lee, C. L., Huang, C. J., Yang, S. H., Chang, C. C., Huang, C. C., Chien, C. C. & Yang, R. N., Nov 1 2016, In: Oncology Letters. 12, 5, p. 3378-3384 7 p.

  Research output: Contribution to journal › Article › peer-review
  13 Citations (Scopus)

• Discovery of enzymes for toluene synthesis from anoxic microbial communities

  Beller, H. R., Rodrigues, A. V., Zargar, K., Wu, Y. W., Saini, A. K., Saville, R. M., Pereira, J. H., Adams, P. D., Tringe, S. G., Petzold, C. J. & Keasling, J. D., May 1 2018, In: Nature Chemical Biology. 14, 5, p. 451-457 7 p.

  Research output: Contribution to journal › Article › peer-review
  34 Citations (Scopus)

• Discovery of a role of the novel hepatokine, hepassocin, in obesity

  Huang, R. L., Li, C. H., Du, Y. F., Cheng, K. P., Lin, C. H., Hu, C. Y., Wu, J. S., Chang, C. J., Wu, H. T. & Ou, H. Y., Jan 2020, In: BioFactors. 46, 1, p. 100-105 6 p.

  Research output: Contribution to journal › Article › peer-review
  9 Citations (Scopus)

• Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations

  Tseng, T. S., Chuang, S. M., Hsiao, N. W., Chen, Y. W., Lee, Y. C., Lin, C. C., Huang, C. & Tsai, K. C., Jan 1 2016, In: Molecular BioSystems. 12, 8, p. 2541-2551 11 p.

  Research output: Contribution to journal › Article › peer-review
  3 Citations (Scopus)

• Discovery of a novel cyclin-dependent kinase 8 inhibitor with an oxindole core for anti-inflammatory treatment

  Lin, T. E., Yang, C. R., Chou, C. H., Hsu, J. Y., Chao, M. W., Sung, T. Y., Hsieh, J. H., Huang, W. J. & Hsu, K. C., Feb 2022, In: Biomedicine and Pharmacotherapy. 146, 112459.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  4 Citations (Scopus)

• Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activities

  Chao, S. W., Chen, L. C., Yu, C. C., Liu, C. Y., Lin, T. E., Guh, J. H., Wang, C. Y., Chen, C. Y., Hsu, K. C. & Huang, W. J., Jan 1 2018, In: European Journal of Medicinal Chemistry. 143, p. 792-805 14 p.

  Research output: Contribution to journal › Article › peer-review
  16 Citations (Scopus)

• Discovery of akt kinase inhibitors through structure-based virtual screening and their evaluation as potential anticancer agents

  Chuang, C. H., Cheng, T. C., Leu, Y. L., Chuang, K. H., Tzou, S. C. & Chen, C. S., Feb 2 2015, In: International journal of molecular sciences. 16, 2, p. 3202-3212 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  27 Citations (Scopus)

• Discovery of 5-(2′,4′-difluorophenyl)-salicylanilides as new inhibitors of receptor activator of NF-κ°B ligand (RANKL)-induced osteoclastogenesis

  Lee, C. C., Liu, F. L., Chen, C. L., Chen, T. C., Chang, D. M. & Huang, H. S., May 25 2015, In: European Journal of Medicinal Chemistry. 98, p. 115-126 12 p.

  Research output: Contribution to journal › Article › peer-review
  28 Citations (Scopus)

• Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors

  Liou, J. P., Wu, Z. Y., Kuo, C. C., Chang, C. Y., Lu, P. Y., Chen, C. M., Hsieh, H. P. & Chang, J. Y., Jul 24 2008, In: Journal of Medicinal Chemistry. 51, 14, p. 4351-4355 5 p.

  Research output: Contribution to journal › Article › peer-review
  70 Citations (Scopus)

• Discovery and quantification of Irgacure-907 in commercial cow milk by using untargeted liquid chromatography high-resolution mass spectrometry

  Tseng, Z-R., Wei, C-C., Wang, S-Y. & Liao, H-W., 2020, In: Journal of Food Composition and Analysis.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• Discovery and mechanisms of host defense to oncogenesis: targeting the β-defensin-1 peptide as a natural tumor inhibitor

  Sun, C. Q., Arnold, R. S., Hsieh, C. L., Dorin, J. R., Lian, F., Li, Z. & Petros, J. A., Jun 3 2019, In: Cancer Biology and Therapy. 20, 6, p. 774-786 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  8 Citations (Scopus)

• Discover the semantic topology in high-dimensional data

  Chiang, I. J., Jul 2007, In: Expert Systems with Applications. 33, 1, p. 256-262 7 p.

  Research output: Contribution to journal › Article › peer-review
  9 Citations (Scopus)

• Discovering the two-step lag behavioral patterns of learners in the college SPOC platform

  Liu, Z., Cheng, H. N. H., Liu, S. & Sun, J., Jan 1 2017, In: International Journal of Information and Communication Technology Education. 13, 1, p. 1-13 13 p.

  Research output: Contribution to journal › Article › peer-review
  8 Citations (Scopus)

• Discovering neutralizing antibodies targeting the stem epitope of H1N1 influenza hemagglutinin with synthetic phage-displayed antibody libraries

  Tung, C. P., Chen, I. C., Yu, C. M., Peng, H. P., Jian, J. W., Ma, S. H., Lee, Y. C., Jan, J. T. & Yang, A. S., Oct 12 2015, In: Scientific Reports. 5, 15053.

  Research output: Contribution to journal › Article › peer-review
  16 Citations (Scopus)

• Discovering Latent Semantics in Web Documents Using Fuzzy Clustering

  Chiang, I-J., Liu, C. C. H., Tsai, Y. H. & Kumar, A., Dec 1 2015, In: IEEE Transactions on Fuzzy Systems. 23, 6, p. 2122-2134 13 p., 7042824.

  Research output: Contribution to journal › Article › peer-review
  28 Citations (Scopus)

• Discovering imaging endophenotypes for major depression

  Hasler, G. & Northoff, G., Jun 2011, In: Molecular Psychiatry. 16, 6, p. 604-619 16 p.

  Research output: Contribution to journal › Article › peer-review
  224 Citations (Scopus)

• Discovering Elements and Developing Strategies to Implement the Tailored Care Education for Patients with Diabetes through A Systematic Review

  Pranata, S., Vivienne Wu, S. F., Tiffany Wang, T. J., Liang, S. Y., Chuang, Y. H., Lu, K. C. & Khoiriyah, K., Apr 2022, In: Nurse Media Journal of Nursing. 12, 1, p. 75-87 13 p.

  Research output: Contribution to journal › Review article › peer-review
  3 Citations (Scopus)

• Discovering EEG signals response to musical signal stimuli by time-frequency analysis and independent component analysis

  Lin, W. C., Chiu, H. W. & Hsu, C-Y., 2005, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 7 VOLS. p. 2765-2768 4 p. 1617045

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
  20 Citations (Scopus)

• Discovering drug targets for cancer therapy

  Huang, T-C., Chang, H-Y. & Juan, H. F., 2012, World Scientific Publishing Co. Pte Ltd. 299 p.

  Research output: Book/Report › Book

• Discourse organization in high school students' writing and their teachers' writing instruction: The case of taiwan

  Chien, S. C., Jun 2011, In: Foreign Language Annals. 44, 2, p. 417-435 19 p.

  Research output: Contribution to journal › Article › peer-review
  13 Citations (Scopus)

• Discordant molecular characterization results in a Mycobacterium avium complex strain isolated from an AIDS patient

  Huang, T. S., Lee, S. S. J., Chen, Y. S., Tu, H. Z., Huang, W. K. & Liu, Y. C., Jul 2005, In: Journal of Medical Microbiology. 54, 7, p. 681-683 3 p.

  Research output: Contribution to journal › Article › peer-review

• Discontinuous residues of factor IX constitute a surface for binding the anti-factor IX monoclonal antibody A-5

  Chang, Y. J., Wu, H. L., Hsu, Y. C., Hamaguchi, N., Shi, G. Y., Shen, M. C. & Lin, S. W., 2003, In: Thrombosis Research. 111, 4-5, p. 293-299 7 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• Discontinuation rate of newly prescribed donepezil in alzheimer’s disease patients in asia

  Park, K. H., Yang, Y., Chen, C., Shim, Y. S., Dominguez, J. C., Lee, C. N., Kang, K., Kim, H. J., Jeong, S. K., Jeong, J. H., Hong, Z., Yoon, S. J., Zhang, Z. X., Kim, E. J., Jang, J. W., Li, Y., Xu, Y., Lin, Y. T., Qu, Q., Hu, C. J., & 10 othersChou, C. H., Fan, D., Kandiah, N., Yang, Y. H., Lau, C. I., Chu, L. W., Wang, H., Jung, S., Choi, S. H. & Kim, S., Jul 2021, In: Journal of Clinical Neurology (Korea). 17, 3, p. 376-384 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  3 Citations (Scopus)

• Discontinuation of lamivudine treatment for hepatitis flare after kidney or heart transplantation in hepatitis B surface antigen-positive patients: A retrospective case series

  Huang, Y. W., Liu, C. J., Lai, M. Y., Lee, P. H., Tsai, M. K., Wang, S. S., Lai, M. K. & Kao, J. H., Sept 2006, In: Clinical Therapeutics. 28, 9, p. 1327-1334 8 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• Discoloration Improvement by Mechanically-Milled Binary Oxides as Radiopacifier for Mineral Trioxide Aggregates

  Lin, H. N., Wang, L. C., Chen, M. S., Chang, P. J., Lin, P. Y., Fang, A., Chen, C. Y., Lee, P. Y. & Lin, C. K., Nov 2022, In: Materials. 15, 22, 7934.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Discoid menisci and their treatment

  Chen, C. H. & Lee, C. H., Feb 21 2017, The Menisci: A Comprehensive Review of their Anatomy, Biomechanical Function and Surgical Treatment. Springer Berlin Heidelberg, p. 165-173 9 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Discoidin Domain Receptor-Driven Gene Signatures as Markers of Patient Response to Anti-PD-L1 Immune Checkpoint Therapy

  You, S., Kim, M., Hoi, X. P., Lee, Y. C., Wang, L., Spetzler, D., Abraham, J., Magee, D., Jain, P., Galsky, M. D., Chan, K. S. & Theodorescu, D., Oct 6 2022, In: Journal of the National Cancer Institute. 114, 10, p. 1380-1391 12 p.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• Discoidin domain receptor-1 (DDR1) is involved in angiolymphatic invasion in oral cancer

  Chen, Y. L., Tsai, W. H., Ko, Y. C., Lai, T. Y., Cheng, A. J., Shiah, S. G., Hsiao, J. R., Chang, J. Y. & Lin, S. F., Apr 2020, In: Cancers. 12, 4, 841.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  14 Citations (Scopus)

• Disclosure of the cancer diagnosis as it relates to the quality of pain management among patients with cancer pain in Taiwan

  Lin, C-C., 1999, In: Journal of Pain and Symptom Management. 18, 5, p. 331-337 7 p.

  Research output: Contribution to journal › Article › peer-review
  32 Citations (Scopus)

• Disaster Medicine Training for Paramedics in Taiwan

  Wang, T. & Chang, H., 2006, In: Annals of Disaster Medicine. 4, 2, p. 60-65

  Research output: Contribution to journal › Article › peer-review

• Disaster epidemiology and medical response in the Chi-Chi earthquake in Taiwan

  Liang, N. J., Shih, Y. T., Shih, F. Y., Wu, H. M., Wang, H-J., Shi, S. F., Liu, M. Y. & Wang, B. B., Jan 1 2001, In: Annals of Emergency Medicine. 38, 5, p. 549-555 7 p.

  Research output: Contribution to journal › Article › peer-review
  73 Citations (Scopus)

• Disassembly and dislocation of a bipolar hip prosthesis

  Lee, H. H., Lo, Y. C., Lin, L. C. & Wu, S. S., Jan 2008, In: Journal of the Formosan Medical Association. 107, 1, p. 84-88 5 p.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• Disappearing Calvarium in Gorham Disease: MR Imaging Characteristics with Pathologic Correlation

  Lo, C. P., Chen, C. Y., Chin, S. C., Juan, C. J., Hsueh, C. J. & Chen, A., Mar 2004, In: American Journal of Neuroradiology. 25, 3, p. 415-418 4 p.

  Research output: Contribution to journal › Article › peer-review
  26 Citations (Scopus)

• Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts

  Yoshizumi, M., Lee, W. S., Hsieh, C. M., Tsai, J. C., Li, J., Perrella, M. A., Patterson, C., Endege, W. O., Schlegel, R. & Lee, M. E., May 1995, In: Journal of Clinical Investigation. 95, 5, p. 2275-2280 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  52 Citations (Scopus)

• Disablement

  Janke, M. C., Chen, T-Y. & Young, T. L., 2015, The Encyclopedia of Adulthood and Aging.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Disabled-2 is a negative immune regulator of lipopolysaccharide-stimulated Toll-like receptor 4 internalization and signaling

  Hung, W. S., Ling, P., Cheng, J. C., Chang, S. S. & Tseng, C. P., Oct 17 2016, In: Scientific Reports. 6, 35343.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  14 Citations (Scopus)

• Disability in patients with chronic neck pain: Heart rate variability analysis and cluster analysis

  Kang, J. H., Chen, H. S., Chen, S. C. & Jaw, F. S., Nov 2012, In: Clinical Journal of Pain. 28, 9, p. 797-803 7 p.

  Research output: Contribution to journal › Article › peer-review
  36 Citations (Scopus)

• Disability and hospital care expenses among national health insurance beneficiaries: Analyses of population-based data in Taiwan

  Lin, L. P., Lee, J. T., Lin, F. G., Lin, P. Y., Tang, C. C., Chu, C. M., Wu, C. L. & Lin, J. D., Sept 1 2011, In: Research in Developmental Disabilities. 32, 5, p. 1589-1595 7 p.

  Research output: Contribution to journal › Article › peer-review
  15 Citations (Scopus)

• Disability among the elderly of Taiwan

  Hsieh, R. L., Lein, I. N., Lee, W. C. & Lee, T. K., 1995, In: American Journal of Physical Medicine and Rehabilitation. 74, 5, p. 370-374 5 p.

  Research output: Contribution to journal › Article › peer-review
  10 Citations (Scopus)

• Direct visualization of microcirculation impairment after acute subdural hemorrhage in a novel animal model

  Wang, H. C., Tsai, J. C., Lee, J. E., Huang, S. J., Po-Hao Huang, A., Lin, W. C., Hsieh, S. T. & Wang, K. C., Oct 2018, In: Journal of Neurosurgery. 129, 4, p. 997-1007 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  3 Citations (Scopus)