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  4β-Hydroxywithanolide E from Physalis peruviana (golden berry) inhibits growth of human lung cancer cells through DNA damage, apoptosis and G2/M arrest

  Yen, C. Y., Chiu, C. C., Chang, F. R., Chen, J. Y., Hwang, C. C., Hseu, Y. C., Yang, H. L., Lee, A. Y. L., Tsai, M. T., Guo, Z. L., Cheng, Y. S., Liu, Y. C., Lan, Y. H., Chang, Y. C., Ko, Y. C., Chang, H. W. & Wu, Y. C., Feb 18 2010, In: BMC Cancer. 10, 46.

  Research output: Contribution to journal › Article › peer-review
  83 Citations (Scopus)

• 5,5-Diphenyl-2-thiohydantoin-N10 (DPTH-N10) suppresses proliferation of cultured colon cancer cell line COLO-205 by inhibiting DNA synthesis and activating apoptosis

  Lee, T. S., Chen, L. C., Liu, Y., Wu, J., Liang, Y. C. & Lee, W. S., Jul 2010, In: Naunyn-Schmiedeberg's Archives of Pharmacology. 382, 1, p. 43-50 8 p.

  Research output: Contribution to journal › Article › peer-review
  9 Citations (Scopus)

• 5-(2-Aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: Variation of N-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance

  Ruchelman, A. L., Houghton, P. J., Zhou, N., Liu, A., Liu, L-F. & LaVoie, E. J., Feb 10 2005, In: Journal of Medicinal Chemistry. 48, 3, p. 792-804 13 p.

  Research output: Contribution to journal › Article › peer-review
  97 Citations (Scopus)

• 5#x02B9;-CGA Motif Induces Other Sequences To Form Homo Base-Paired Parallel-Stranded DNA Duplex: The Structure of (G-A)_n Derived from Four DNA Oligomers Containing (G-A)₃ Sequence

  Robinson, H., Wang, A. H. J. & van Boom, J. H., Feb 1 1994, In: Journal of the American Chemical Society. 116, 4, p. 1565-1566 2 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• 500-Gray γ-Irradiation May Increase Adhesion Strength of Lyophilized Cadaveric Split-Thickness Skin Graft to Wound Bed

  Wei, L. G., Chen, C. F., Wang, C. H., Cheng, Y. C., Li, C. C., Chiu, W. K. & Wang, H-J., 2017, In: Annals of Plastic Surgery. 78, 3

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• 58-kDa microspherule protein (MSP58) is novel brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway

  Hsu, C. C., Lee, Y. C., Yeh, S. H., Chen, C. H., Wu, C. C., Wang, T. Y., Chen, Y. N., Hung, L. Y., Liu, Y. W., Chen, H. K., Hsiao, Y. T., Wang, W. S., Tsou, J. H., Tsou, Y. H., Wu, M. H., Chang, W. C. & Lin, D. Y., Jun 29 2012, In: Journal of Biological Chemistry. 287, 27, p. 22533-22548 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  33 Citations (Scopus)

• 5A/6A polymorphism of the stromelysin-1 gene and angiographic restenosis after coronary artery stenting

  Chiou, K. R., Chung, S. L. & Charng, M. J., Jan 1 2005, In: Journal of the Chinese Medical Association. 68, 11, p. 506-512 7 p.

  Research output: Contribution to journal › Article › peer-review
  2 Citations (Scopus)

• 5-ALA mediated photodynamic therapy induces autophagic cell death via AMP-activated protein kinase

  Ji, H-T., Chien, L-T., Lin, Y-H., Chien, H-F. & Chen, C-T., 2010, In: Molecular Cancer. 9

  Research output: Contribution to journal › Article › peer-review
  45 Citations (Scopus)

• 5-Amino-2-Aroylquinolines as highly potent tubulin polymerization inhibitors

  Nien, C. Y., Chen, Y. C., Kuo, C. C., Hsieh, H. P., Chang, C. Y., Wu, J. S., Wu, S. Y., Liou, J. P. & Chang, J. Y., Mar 11 2010, In: Journal of Medicinal Chemistry. 53, 5, p. 2309-2313 5 p.

  Research output: Contribution to journal › Article › peer-review
  75 Citations (Scopus)

• 5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2

  Lee, H. Y., Chang, J. Y., Nien, C. Y., Kuo, C. C., Shih, K. H., Wu, C. H., Chang, C. Y., Lai, W. Y. & Liou, J. P., Dec 22 2011, In: Journal of Medicinal Chemistry. 54, 24, p. 8517-8525 9 p.

  Research output: Contribution to journal › Article › peer-review
  49 Citations (Scopus)

• 5-Aminolevulinic acid induced photodynamic inactivation on Staphylococcus aureus and Pseudomonas aeruginosa

  Hsieh, C. M., Huang, Y. H., Chen, C. P., Hsieh, B. C. & Tsai, T., 2014, In: Journal of Food and Drug Analysis. 22, 3, p. 350-355 6 p.

  Research output: Contribution to journal › Article › peer-review
  26 Citations (Scopus)

• 5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

  Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Aug 23 2018, In: Journal of Medicinal Chemistry. 61, 16, p. 7087-7102 16 p.

  Research output: Contribution to journal › Article › peer-review
  46 Citations (Scopus)

• 5'-CGA Sequence is a strong motif for homo base-paired parallel-stranded DNA duplex as revealed by NMR analysis

  Robinson, H. & Wang, A. H. J., 1993, In: Proceedings of the National Academy of Sciences of the United States of America. 90, 11, p. 5224-5228 5 p.

  Research output: Contribution to journal › Article › peer-review
  15 Citations (Scopus)

• 5-Demethylnobiletin and 5-Acetoxy-6,7,8,3′,4′-pentamethoxyflavone Suppress Lipid Accumulation by Activating the LKB1-AMPK Pathway in 3T3-L1 Preadipocytes and High Fat Diet-Fed C57BL/6 Mice

  Tung, Y. C., Li, S., Huang, Q., Hung, W. L., Ho, C. T., Wei, G. J. & Pan, M. H., Apr 27 2016, In: Journal of Agricultural and Food Chemistry. 64, 16, p. 3196-3205 10 p.

  Research output: Contribution to journal › Article › peer-review
  26 Citations (Scopus)

• 5-Demethylnobiletin Inhibits Cell Proliferation, Downregulates ID1 Expression, Modulates the NF-κB/TNF-α Pathway and Exerts Antileukemic Effects in AML Cells

  Chen, P. Y., Wang, C. Y., Tsao, E. C., Chen, Y. T., Wu, M. J., Ho, C. T. & Yen, J. H., Jul 2022, In: International journal of molecular sciences. 23, 13, 7392.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Citations (Scopus)

• 5-Demethyltangeretin is more potent than tangeretin in inhibiting dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin tumorigenesis

  Ma, N., Lai, C. S., Chung, C. H., Yang, J. M., Hsu, K. C., Chen, C. Y., Chung, T. S., Li, S., Ho, C. T. & Pan, M. H., 2014, In: Journal of Functional Foods. 11, C, p. 528-537 10 p.

  Research output: Contribution to journal › Article › peer-review
  19 Citations (Scopus)

• 5-Fluorodeoxyuridine as an alternative to the synthesis of mixed hybridization probes for the detection of specific gene sequences

  Habener, J. F., Vo, C. D., Le, D. B., Gryan, G. P., Ercolani, L. & Wang, A. H. J., 1988, In: Proceedings of the National Academy of Sciences of the United States of America. 85, 6, p. 1735-1739 5 p.

  Research output: Contribution to journal › Article › peer-review
  29 Citations (Scopus)

• 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6] naphthyridin-6-ones and related compounds as TOP1-targeting agents: Influence of structure on the ternary cleavable complex formation

  Kerrigan, J. E., Pilch, D. S., Ruchelman, A. L., Zhou, N., Liu, A., Liu, L. & LaVoie, E. J., Oct 20 2003, In: Bioorganic and Medicinal Chemistry Letters. 13, 20, p. 3395-3399 5 p.

  Research output: Contribution to journal › Article › peer-review
  3 Citations (Scopus)

• 5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: Novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity

  Ruchelman, A. L., Singh, S. K., Ray, A., Wu, X. H., Yang, J. M., Li, T. K., Liu, A., Liu, L. F. & LaVoie, E. J., May 1 2003, In: Bioorganic and Medicinal Chemistry. 11, 9, p. 2061-2073 13 p.

  Research output: Contribution to journal › Article › peer-review
  109 Citations (Scopus)

• 5-HT modulates multiple conductances in immature rat rostral ventrolateral medulla neurones in vitro

  Hwang, L. L. & Dun, N. J., May 15 1999, In: Journal of Physiology. 517, 1, p. 217-228 12 p.

  Research output: Contribution to journal › Article › peer-review
  3 Citations (Scopus)

• 5-Hydroxytryptamine responses in immature rat rostral ventrolateral medulla neurons in vitro

  Hwang, L-L. & Dun, N. J., Sept 1998, In: Journal of Neurophysiology. 80, 3, p. 1033-1041 9 p.

  Research output: Contribution to journal › Article › peer-review
  10 Citations (Scopus)

• 5′CpG island hypermethylation and aberrant transcript splicing both contribute to the inactivation of the FHIT gene in resected non-small cell lung cancer

  Tzao, C., Tsai, H. Y., Chen, J. T., Chen, C. Y. & Wang, Y. C., Sept 2004, In: European Journal of Cancer. 40, 14, p. 2175-2183 9 p.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• 5-氟尿嘧啶單獨或併用遊離輻射治療人類結腸直腸癌細胞之效果

  Translated title of the contribution: Combined Treatment Effect of 5-Fluorouracil with Ionizing Radiation on Human Colorectal Carcinoma Cells黃正仲, 陳柏元, 鄧文炳, 黃家瑜, 林冠如, 吳國海, 傅秉三 & 林芳仁, 1999, In: 放射治療與腫瘤學. 6, 2, p. 73-82 10 p.

  Research output: Contribution to journal › Article › peer-review

• 6,7-dihydroxy-2-(4′-hydroxyphenyl)naphthalene induces HCT116 cell apoptosis through activation of endoplasmic reticulum stress and the extrinsic apoptotic pathway

  Chiu, C. F., Lai, G. Y., Chen, C. H., Chiu, C. C., Hung, S. W. & Chang, C. F., Jan 1 2019, In: Drug Design, Development and Therapy. 13, p. 1609-1621 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  5 Citations (Scopus)

• ⁶⁰Co contamination in recycled steel resulting in elevated civilian radiation doses: Causes and challenges

  Chang, W. P., Chan, C. C. & Wang, J. D., Sept 1997, In: Health Physics. 73, 3, p. 465-472 8 p.

  Research output: Contribution to journal › Article › peer-review
  27 Citations (Scopus)

• 677TT polymorphism of methelenetetrahydrofolate reductase in combination with low serum vitamin B12 is associated with coronary in-stent restenosis

  Chung, S. L., Chiou, K. R. & Charng, M. J., Mar 1 2006, In: Catheterization and Cardiovascular Interventions. 67, 3, p. 349-355 7 p.

  Research output: Contribution to journal › Article › peer-review

• 6-Acyl-4-aryl/alkyl-5,7-dihydroxycoumarins as anti-inflammatory agents

  Lin, C. M., Huang, S. T., Lee, F. W., Kuo, H-S. & Lin, M. H., Jul 1 2006, In: Bioorganic and Medicinal Chemistry. 14, 13, p. 4402-4409 8 p.

  Research output: Contribution to journal › Article › peer-review
  56 Citations (Scopus)

• 6-Dehydrogingerdione sensitizes human hepatoblastoma hep G2 cells to trail-induced apoptosis via reactive oxygen species-mediated increase of dr5

  Chen, C. Y., Tai, C. J., Cheng, J. T., Zheng, J. J., Chen, Y. Z., Liu, T. Z., Yiin, S. J. & Chern, C. L., May 12 2010, In: Journal of Agricultural and Food Chemistry. 58, 9, p. 5604-5611 8 p.

  Research output: Contribution to journal › Article › peer-review
  25 Citations (Scopus)

• 6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: Reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity

  Zhu, S., Ruchelman, A. L., Zhou, N., Liu, A., Liu, L. F. & LaVoie, E. J., May 1 2006, In: Bioorganic and Medicinal Chemistry. 14, 9, p. 3131-3143 13 p.

  Research output: Contribution to journal › Article › peer-review
  16 Citations (Scopus)

• 7-Acetylsinumaximol b induces apoptosis and autophagy in human gastric carcinoma cells through mitochondria dysfunction and activation of the perk/eif2α/atf4/chop signaling pathway

  Tsai, T. C., Lai, K. H., Su, J. H., Wu, Y. J. & Sheu, J. H., Apr 2018, In: Marine Drugs. 16, 4, 104.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  33 Citations (Scopus)

• 7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents

  Chang, J. Y., Hsieh, H. P., Chang, C. Y., Hsu, K. S., Chiang, Y. F., Chen, C. M., Kuo, C. C. & Liou, J. P., Nov 16 2006, In: Journal of Medicinal Chemistry. 49, 23, p. 6656-6659 4 p.

  Research output: Contribution to journal › Article › peer-review
  54 Citations (Scopus)

• 7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel ROCK inhibitor blocks cytoskeleton function and cell migration

  Tsai, C. C., Liu, H. F., Hsu, K. C., Yang, J. M., Chen, C., Liu, K. K., Hsu, T. S. & Chao, J. I., Apr 1 2011, In: Biochemical Pharmacology. 81, 7, p. 856-865 10 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• 7-Ketocholesterol and cholesterol-5α,6α-epoxide induce smooth muscle cell migration and proliferation through the epidermal growth factor receptor/phosphoinositide 3-kinase/Akt signaling pathways

  Liao, P. L., Cheng, Y. W., Li, C. H., Wang, Y. T. & Kang, J. J., Aug 2010, In: Toxicology Letters. 197, 2, p. 88-96 9 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• 8,9-Methylenedioxybenzo[i]phenanthridines: Topoisomerase I-targeting activity and cytotoxicity

  Li, D., Zhao, B., Sim, S. P., Li, T. K., Liu, A., Liu, L. F. & LaVoie, E. J., Aug 15 2003, In: Bioorganic and Medicinal Chemistry. 11, 17, p. 3795-3805 11 p.

  Research output: Contribution to journal › Article › peer-review
  24 Citations (Scopus)

• 836 10-years experience in cystitis glandularis

  Chang, C. H. C., Chen, K-K., Lin, T. L., Pan, C-C., Chang, Y-H., Huang, J., Kuo, J-Y., Chung, H-J. & Lin, T. L., Apr 1 2015, In: European Urology, Supplements. 14, 2, p. e836

  Research output: Contribution to journal › Article › peer-review

• 872 IL-1β is a potential central mediator to Papulopustular Rosacea pathology as determined by paired transcriptomic and proteomic analysis

  Harden, J., Shih, Y., Rajendran, D., Xu, J., Li, R., Hofland, H. & Chang, A. L., 2020, In: Journal of Investigative Dermatology. 140, 7, Supplement, p. S114

  Research output: Contribution to journal › Article › peer-review

• 8‐hydroxydaidzein, an isoflavone from fermented soybean, induces autophagy, apoptosis, differentiation, and degradation of oncoprotein bcr‐abl in k562 cells

  Wu, P. S., Yen, J. H., Wang, C. Y., Chen, P. Y., Hung, J. H. & Wu, M. J., Nov 2020, In: Biomedicines. 8, 11, p. 1-23 23 p., 506.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  15 Citations (Scopus)

• 8-hydroxydaidzein downregulates JAK/STAT, MMP, oxidative phosphorylation, and PI3K/AKT pathways in K562 cells

  Wu, P. S., Wang, C. Y., Chen, P. S., Hung, J. H., Yen, J. H. & Wu, M. J., Dec 2021, In: Biomedicines. 9, 12, 1907.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  7 Citations (Scopus)

• 981 Alterations of gene expression in papulopustular rosacea by whole transcriptome analysis

  Shih, Y., Xu, J., Kumar, A., Li, R. & Chang, A., 2019, In: Journal of Investigative Dermatology. 139, 5, Supplement, p. S170

  Research output: Contribution to journal › Article › peer-review

• 99mTc pyrene derivative complex causes double-strand breaks in dsDNA mainly through cluster-mediated indirect effect in aqueous solution

  Chung, W. J., Cui, Y., Huang, F. Y. J., Tu, T. H., Yang, T. S., Lo, J. M., Chiang, C. S. & Hsu, I. C., Sept 22 2014, In: PLoS One. 9, 9, e108162.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• ^99mTc-TRODAT-1 SPECT in healthy and 6-OHDA lesioned parkinsonian monkeys: Comparison with ¹⁸F-FDOPA PET

  Huang, W. S., Ma, K. H., Chou, Y. H., Chen, C. Y., Liu, R. S. & Liu, J. C., Jan 2003, In: Nuclear Medicine Communications. 24, 1, p. 77-83 7 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• ^99mTc-TRODAT-1 SPECT Revealed That Striatal Dopamine Transport Availability Significantly Decreases in Late Mid-Aged Healthy Taiwanese and Then Remains Stable

  Yeh, S. H. H., Tsai, C. J., Yu, T. H., Chiang, Y. H., Lin, S. Z., Peng, N. J. & Huang, W. S., Mar 1 2022, In: Clinical Nuclear Medicine. 47, 3, p. 201-208 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Citations (Scopus)

• 9-Anthracenecarboxamide fluorescent probes for selective discrimination of picric acid from mono- and di-nitrophenols in ethanol

  Pandith, A., Kumar, A., Lee, J. Y. & Kim, H. S., Dec 23 2015, In: Tetrahedron Letters. 56, 51, p. 7094-7099 6 p.

  Research output: Contribution to journal › Article › peer-review
  33 Citations (Scopus)

• 9-cis retinoic acid induces neurorepair in stroke brain

  Yu, S. J., Airavaara, M., Wu, K. J., Harvey, B. K., Liu, H. S., Yang, Y., Zacharek, A., Chen, J. & Wang, Y., Dec 1 2017, In: Scientific Reports. 7, 1, 4512.

  Research output: Contribution to journal › Article › peer-review
  15 Citations (Scopus)

• 9-cis retinoic acid induces retinoid X receptor localized to the mitochondria for mediation of mitochondrial transcription

  Lin, Y. W., Lien, L. M., Yeh, T. S., Wu, H. M., Liu, Y. L. & Hsieh, R. H., Dec 12 2008, In: Biochemical and Biophysical Research Communications. 377, 2, p. 351-354 4 p.

  Research output: Contribution to journal › Article › peer-review
  14 Citations (Scopus)

• 9-Cis-retinoic acid reduces ischemic brain injury in rodents via bone morphogenetic protein

  Shen, H., Luo, Y., Kuo, C. C., Deng, X., Fang, C. F., Harvey, B. K., Hoffer, B. J. & Wang, Y., Feb 1 2009, In: Journal of Neuroscience Research. 87, 2, p. 545-555 11 p.

  Research output: Contribution to journal › Article › peer-review
  32 Citations (Scopus)

• 9-N-Alkylaminomethylanthracene probes for selective fluorescence sensing of pentafluorophenol

  Pandith, A., Kumar, A. & Kim, H. S., Sept 18 2015, In: RSC Advances. 5, 100, p. 81808-81816 9 p.

  Research output: Contribution to journal › Article › peer-review
  22 Citations (Scopus)

• A 10-item Fugl-Meyer Motor Scale Based on Machine Learning

  Lin, G. H., Huang, C. Y., Lee, S. C., Chen, K. L., Lien, J. J. J., Chen, M. H., Huang, Y. H. & Hsieh, C. L., Apr 1 2021, In: Physical Therapy. 101, 4

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• A 10-year follow-up of triple-negative breast cancer patients in Taiwan

  Lin, C., Chien, S. Y., Kuo, S. J., Chen, L. S., Chen, S. T., Lai, H. W., Chang, T. W. & Chen, D. R., Mar 2012, In: Japanese Journal of Clinical Oncology. 42, 3, p. 161-167 7 p., hyr196.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• A 10-year follow-up study on suicidal mortality after 1999 Taiwan earthquake

  Chen, S. L. S., Lee, C. S., Yen, A. M. F., Chen, H. H., Chan, C. C., Chiu, S. Y. H., Fann, J. C. Y. & Chang, J. C., Aug 1 2016, In: Journal of Psychiatric Research. 79, p. 42-49 8 p.

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)