Find Research outputs

Activation and induction of cytosolic phospholipase A2 by TNF-α mediated through Nox2, MAPKs, NF-κB, and p300 in human tracheal smooth muscle cells

Lee, C-W., Lin, C-C., Lee, I-T., Lee, H-C. & Yang, C-M., Aug 2011, In: Journal of Cellular Physiology. 226, 8, p. 2103-14 12 p.

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Activation and up-regulation of nitric oxide synthase in human umbilical vein endothelial cells by polycyclic aromatic hydrocarbons

Li, C. H., Lee, C. C., Cheng, Y. W., Juang, H. A. & Kang, J. J., Jul 15 2004, In: Toxicology Letters. 151, 2, p. 367-374 8 p.

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Activation by zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells

Huang, C. W., Huang, C. C. & Wu, S. N., Apr 2007, In: Journal of Pharmacology and Experimental Therapeutics. 321, 1, p. 98-106 9 p.

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Activation of a hippocampal CREB-pCREB-miRNA-MEF2 axis modulates individual variation of spatial learning and memory capability

Wang, I. F., Wang, Y., Yang, Y. H., Huang, G. J., Tsai, K. J. & Shen, C. K. J., Aug 2021, In: Cell Reports. 36, 5, 109477.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Activation of a novel ubiquitin-independent proteasome pathway when RNA polymerase II encounters a protein roadblock

Ban, Y., Ho, C. W., Lin, R. K., Lyu, Y. L. & Liu, L. F., 2013, In: Molecular and Cellular Biology. 33, 20, p. 4008-4016 9 p.

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Activation of a nuclear factor of activated T-lymphocyte-3 (NFAT3) by oxidative stress in carboplatin-mediated renal apoptosis

Lin, H., Sue, Y. M., Chou, Y., Cheng, C. F., Chang, C. C., Li, H. F., Chen, C. C. & Juan, S. H., Dec 2010, In: British Journal of Pharmacology. 161, 7, p. 1661-1676 16 p.

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Activation of aryl hydrocarbon receptor by kynurenine impairs progression and metastasis of neuroblastoma

Wu, P. Y., Yu, I. S., Lin, Y. C., Chang, Y. T., Chen, C. C., Lin, K. H., Tseng, T. H., Kargren, M., Tai, Y. L., Shen, T. L., Liu, Y. L., Wang, B. J., Chang, C. H., Chen, W. M., Juan, H. F., Huang, S. F., Chan, Y. Y., Liao, Y. F., Hsu, W. M. & Lee, H., Nov 1 2019, In: Cancer Research. 79, 21, p. 5550-5562 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Citations (Scopus)

Activation of Brain L-glutamate Decarboxylase 65 Isoform (GAD65) by Phosphorylation at Threonine 95 (T95)

Chou, C. C., Modi, J. P., Wang, C. Y., Hsu, P. C., Lee, Y-H., Huang, K. F., Wang, A. H. J., Nan, C., Huang, X., Prentice, H., Wei, J. & Wu, J. Y., Mar 1 2017, In: Molecular Neurobiology. 54, 2, p. 866-873 8 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Activation of brainstem catecholaminergic neurons by conditioned and unconditioned aversive stimuli as revealed by c-Fos immunoreactivity

Pezzone, M. A., Lee, W. S., Hoffman, G. E., Pezzone, K. M. & Rabin, B. S., Apr 16 1993, In: Brain Research. 608, 2, p. 310-318 9 p.

Research output: Contribution to journal › Article › peer-review

150 Citations (Scopus)

Activation of CDC 25 phosphatase and CDC 2 kinase involved in GL331- induced apoptosis

Huang, T. S., Shu, C. H., Yang, W. K. & Whang-Peng, J., Jul 15 1997, In: Cancer Research. 57, 14, p. 2974-2978 5 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Activation of c-Jun NH₂-terminal kinase and subsequent CPP32/Yama during topoisomerase inhibitor β-lapachone-induced apoptosis through an oxidation-dependent pathway

Shiah, S. G., Chuang, S. E., Chau, Y. P., Shen, S. C. & Kuo, M. L., Jan 16 1999, In: Cancer Research. 59, 2, p. 391-398 8 p.

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Activation of Class I histone deacetylases contributes to mitochondrial dysfunction in cardiomyocytes with altered complex activities

Lkhagva, B., Kao, Y. H., Lee, T. I., Lee, T. W., Cheng, W. L. & Chen, Y. J., Apr 3 2018, In: Epigenetics. 13, 4, p. 376-385 10 p.

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Activation of delta-opioid receptor contributes to the antinociceptive effect of oxycodone in mice

Yang, P. P., Yeh, G. C., Yeh, T. K., Xi, J., Loh, H. H., Law, P. Y. & Tao, P. L., Sept 1 2016, In: Pharmacological Research. 111, p. 867-876 10 p.

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Activation of deoxyribonuclease I by nicotinamide as a new strategy to attenuate tetracycline-resistant biofilms of cutibacterium acnes

Shih, Y. H., Liu, D., Chen, Y. C., Liao, M. H., Lee, W. R. & Shen, S. C., Jun 1 2021, In: Pharmaceutics. 13, 6, 819.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Activation of DNA methyltransferase 1 by EBV LMP1 involves c-Jun NH 2-terminal kinase signaling

Tsai, C. L., Li, H. P., Lu, Y. J., Hsueh, C., Liang, Y., Chen, C. L., Tsao, S. W., Tse, K. P., Yu, J. S. & Chang, Y. S., Dec 15 2006, In: Cancer Research. 66, 24, p. 11668-11676 9 p.

Research output: Contribution to journal › Article › peer-review

147 Citations (Scopus)

Activation of dopamine D₂-like receptors attenuates pulmonary C-fiber hypersensitivity in rats

Lin, Y. S., Gu, Q. & Lee, L. Y., Apr 15 2003, In: American Journal of Respiratory and Critical Care Medicine. 167, 8, p. 1096-1101 6 p.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Activation of estrogen receptor is crucial for resveratrol-stimulating muscular glucose uptake via both insulin-dependent and -independent pathways

Deng, J. Y., Hsieh, P. S., Huang, J. P., Lu, L. S. & Hung, L. M., Jul 2008, In: Diabetes. 57, 7, p. 1814-1823 10 p.

Research output: Contribution to journal › Article › peer-review

130 Citations (Scopus)

Activation of estrogen receptors with E2 downregulates peroxisome proliferator-activated receptor γ in hepatocellular carcinoma

Lin, Y. M., Velmurugan, B. K., Yeh, Y. L., Tu, C. C., Ho, T. J., Lai, T-I., Tsai, C. H., Tsai, F. J., Tsai, C. H. & Huang, C. Y., Dec 2013, In: Oncology Reports. 30, 6, p. 3027-3031 5 p.

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Activation of extracellular signal-regulated kinase (ERK)1/2, but not p38 and c-Jun N-terminal kinase, is involved in signaling of a novel cytokine, ML-1

Kawaguchi, M., Onuchic, L. F. & Huang, S. K., May 3 2002, In: Journal of Biological Chemistry. 277, 18, p. 15229-15232 4 p.

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Activation of extracellular signal-regulated kinase signaling by epidermal growth factor mediates c-Jun activation and p300 recruitment in keratin 16 gene expression

Wang, Y. N., Chen, Y. J. & Chang, W. C., Jan 2006, In: Molecular Pharmacology. 69, 1, p. 85-98 14 p.

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Activation of fibroblast growth factor 8 gene expression in human embryonal carcinoma cells

Wu, J., Payson, R. A., Lang, J. C. & Chiu, I. M., May 1997, In: Journal of Steroid Biochemistry and Molecular Biology. 62, 1, p. 1-10 10 p.

Research output: Contribution to journal › Article › peer-review

Activation of fibroblasts by nicotine promotes the epithelial-mesenchymal transition and motility of breast cancer cells

Chen, P. C., Lee, W. Y., Ling, H. H., Cheng, C. H., Chen, K. C. & Lin, C. W., Jun 2018, In: Journal of Cellular Physiology. 233, 6, p. 4972-4980 9 p.

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Activation of free fatty acid receptor 1 improves hepatic steatosis through a p38-dependent pathway

Ou, H. Y., Wu, H. T., Lu, F. H., Su, Y. C., Hung, H. C., Wu, J. S., Yang, Y. C., Wu, C. L. & Chang, C. J., Jul 9 2014, In: Journal of Molecular Endocrinology. 53, 2, p. 165-174 10 p.

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Activation of gonadotropin-releasing hormone receptors produces neuronal excitation in the rat hippocampus

Lu, F., Yang, J. M., Wu, J. N., Chen, Y. C., Kao, Y. H., Tung, C. S. & Yang, S. N., 1999, In: Chinese Journal of Physiology. 42, 2, p. 67-71 5 p.

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Activation of heme oxygenase-1 by Ginkgo biloba extract differentially modulates endothelial and smooth muscle-like progenitor cells for vascular repair

Wu, T. C., Chen, J. S., Wang, C. H., Huang, P. H., Lin, F. Y., Lin, L. Y., Lin, S. J. & Chen, J. W., Dec 1 2019, In: Scientific Reports. 9, 1, 17316.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Citations (Scopus)

Activation of human orbital fibroblasts through CD40 engagement results in a dramatic induction of hyaluronan synthesis and prostaglandin endoperoxide H synthase-2 expression: Insights into potential pathogenic mechanisms of thyroid-associated ophthalmopathy

Cao, H. J., Wang, H. S., Zhang, Y., Lin, H. Y., Phipps, R. P. & Smith, T. J., Nov 6 1998, In: Journal of Biological Chemistry. 273, 45, p. 29615-29625 11 p.

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Activation of human telomerase reverse transcriptase expression by some new symmetrical bis-substituted derivatives of the anthraquinone

Huang, H. S., Chiou, J. F., Fong, Y., Hou, C. C., Lu, Y. C., Wang, J. Y., Shih, J. W., Pan, Y. R. & Lin, J. J., Jul 17 2003, In: Journal of Medicinal Chemistry. 46, 15, p. 3300-3307 8 p.

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Activation of IGF-I survival signaling and its compensative inhibition of the cardiac apoptosis on carotid arteries balloon-injured rat hearts

Hsieh, C. H., Pai, P., Wu, J. P., Ho, T. J., Wu, C. H., Shibu, M. A., Day, C. H., Viswanadha, V. P., Chuang, H. L. & Huang, C. Y., 2017, In: Chinese Journal of Physiology. 60, 3, p. 166-173 8 p.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Activation of IL6/IGFIR confers poor prognosis of HBV-related hepatocellular carcinoma through induction of OCT4/NANOG expression

Chang, T. S., Wu, Y. C., Chi, C. C., Su, W. C., Chang, P. J., Lee, K. F., Tung, T. H., Wang, J., Liu, J-J., Tung, S. Y., Kuo, L. M., Ho, H. N., Ling, T. Y. & Huang, Y-H., Jan 1 2015, In: Clinical Cancer Research. 21, 1, p. 201-210 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

79 Citations (Scopus)

Activation of imidazoline I2B receptors is linked with AMP kinase pathway to increase glucose uptake in cultured C₂C₁₂ cells

Lui, T. N., Tsao, C. W., Huang, S. Y., Chang, C. H. & Cheng, J. T., May 2010, In: Neuroscience Letters. 474, 3, p. 144-147 4 p.

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Activation of indices of cell-mediated immunity in bipolar mania

Tsai, S. Y., Chen, K. P., Yang, Y. Y., Chen, C. C., Lee, J-C., Singh, V. K. & Leu, S. J. C., Apr 15 1999, In: Biological Psychiatry. 45, 8, p. 989-994 6 p.

Research output: Contribution to journal › Article › peer-review

104 Citations (Scopus)

Activation of iodosobenzene by catalytic tetrabutylammonium iodide and its application in the oxidation of some isoquinoline alkaloids

Huang, W. J., Singh, O. V., Chen, C. H., Chiou, S. Y. & Lee, S. S., 2002, In: Helvetica Chimica Acta. 85, 4, p. 1069-1078 10 p.

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Activation of JNK contributes to evodiamine-induced apoptosis and G ₂/M arrest in human colorectal carcinoma cells: A structure-activity study of evodiamine

Chien, C. C., Wu, M. S., Shen, S. C., Ko, C. H., Chen, C. H., Yang, L. L. & Chen, Y. C., Jun 24 2014, In: PLoS One. 9, 6, e99729.

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Activation of kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2/antioxidant response element pathway by curcumin enhances the anti-oxidative capacity of corneal endothelial cells

Guo, S. P., Chang, H. C., Lu, L. S., Liu, D. Z. & Wang, T. J., Sept 2021, In: Biomedicine and Pharmacotherapy. 141, 111834.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

Activation of MEK2 is sufficient to induce skin papilloma formation in transgenic zebrafish Application of Zebrafish in Biomedical Research

Chou, C. M., Chen, Y. C., Su, S., Chen, G. D., Huang, K. Y., Lien, H. W., Huang, C. J. & Cheng, C. H., Nov 17 2015, In: Journal of Biomedical Science. 22, 1, 102.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Activation of mitogen-activated protein kinase by oxidized low-density lipoprotein in canine cultured vascular smooth muscle cells

Yang, C. M., Chiu, C. T., Wang, C. C., Chien, C. S., Hsiao, L. D., Lin, C. C., Tu, M. T. & Pan, S. L., Apr 2000, In: Cellular Signalling. 12, 4, p. 205-214 10 p.

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats

Yang, T. T., Chang, C. K., Tsao, C. W., Hsu, Y. M., Hsu, C. T. & Cheng, J. T., Feb 13 2009, In: Neuroscience Letters. 451, 1, p. 57-59 3 p.

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Activation of NF-κB by SOD2 promotes the aggressiveness of lung adenocarcinoma by modulating NKX2-1-mediated IKKβ expression

Chen, P. M., Wu, T. C., Wang, Y. C., Cheng, Y. W., Sheu, G. T., Chen, C. Y. & Lee, H., Nov 2013, In: Carcinogenesis. 34, 11, p. 2655-2663 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Citations (Scopus)

Activation of NPFFR2 leads to hyperalgesia through the spinal inflammatory mediator CGRP in mice

Lin, Y. T., Liu, H. L., Day, Y. J., Chang, C. C., Hsu, P. H. & Chen, J. C., May 2017, In: Experimental Neurology. 291, p. 62-73 12 p.

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Activation of Nrf2/HO-1signaling pathway involves the anti-inflammatory activity of magnolol in Porphyromonas gingivalis lipopolysaccharide-stimulated mouse RAW 264.7 macrophages

Lu, S. H., Hsu, W. L., Chen, T. H. & Chou, T. C., Dec 1 2015, In: International Immunopharmacology. 29, 2, p. 770-778 9 p.

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Activation of Nrf2 by Esculetin Mitigates Inflammatory Responses through Suppression of NF-κB Signaling Cascade in RAW 264.7 Cells

Jayakumar, T., Huang, C. J., Yen, T. L., Hsia, C. W., Sheu, J. R., Bhavan, P. S., Huang, W. C., Hsieh, C. Y. & Hsia, C. H., Aug 2022, In: Molecules. 27, 16, 5143.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Activation of Nrf2 by the dengue virus causes an increase in CLEC5A, which enhances TNF-α production by mononuclear phagocytes

Cheng, Y. L., Lin, Y. S., Chen, C. L., Tsai, T. T., Tsai, C. C., Wu, Y. W., Ou, Y. D., Chu, Y. Y., Wang, J. M., Yu, C. Y. & Lin, C. F., Aug 26 2016, In: Scientific Reports. 6, 32000.

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Activation of opioid μ-receptor by sinomenine in cell and mice

Wang, M. H., Chang, C. K., Cheng, J. H., Wu, H. T., Li, Y. X. & Cheng, J. T., Oct 10 2008, In: Neuroscience Letters. 443, 3, p. 209-212 4 p.

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Activation of p38 MAPK-regulated Bcl-xL signaling increases survival against zoledronic acid-induced apoptosis in osteoclast precursors

Tai, T. W., Su, F. C., Chen, C. Y., Jou, I. M. & Lin, C. F., Oct 2014, In: Bone. 67, p. 166-174 9 p.

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Activation of p38 mitogen-activated protein kinase in spinal microglia contributes to incision-induced mechanical allodynia

Wen, Y-R., Suter, M. R., Ji, R. R., Yeh, G. C., Wu, Y. S., Wang, K. C., Kohno, T., Sun, W. Z. & Wang, C. C., Jan 2009, In: Anesthesiology. 110, 1, p. 155-165 11 p.

Research output: Contribution to journal › Article › peer-review

118 Citations (Scopus)

Activation of p53/miR-34a tumor suppressor axis by Chinese herbal formula JP-1 in A549 lung adenocarcinoma cells

Yao, C. J., Chow, J. M., Lin, P. C., Hu, T. S., Kuo, H. C., Huang, J. S., Bai, K. J. & Lai, G. M., 2016, In: Evidence-based Complementary and Alternative Medicine. 2016, 5989681.

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Activation of peripheral TRPM8 mitigates ischemic stroke by topically applied menthol

Huang, S. S., Su, H. H., Chien, S. Y., Chung, H. Y., Luo, S. T., Chu, Y. T., Wang, Y. H., MacDonald, I. J., Lee, H. H. & Chen, Y. H., Dec 2022, In: Journal of Neuroinflammation. 19, 1, 192.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)