9-cis retinoic acid induces neurorepair in stroke brain

Seong Jin Yu; Mikko Airavaara; Kuo Jen Wu; Brandon K. Harvey; H. S. Liu; Yihong Yang; Alex Zacharek; Jieli Chen; Yun Wang

doi:10.1038/s41598-017-04048-2

9-cis retinoic acid induces neurorepair in stroke brain

Seong Jin Yu, Mikko Airavaara, Kuo Jen Wu, Brandon K. Harvey, H. S. Liu, Yihong Yang, Alex Zacharek, Jieli Chen, Yun Wang

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

The purpose of this study was to examine the neurorestorative effect of delayed 9 cis retinoic acid (9cRA) treatment for stroke. Adult male rats received a 90-min right distal middle cerebral artery occlusion (dMCAo). Animals were separated into two groups with similar infarction sizes, based on magnetic resonance imaging on day 2 after dMCAo. 9cRA or vehicle was given via an intranasal route daily starting from day 3. Stroke rats receiving 9cRA post-treatment showed an increase in brain 9cRA levels and greater recovery in motor function. 9cRA enhanced the proliferation of bromodeoxyuridine (+) cells in the subventricular zone (SVZ) and lesioned cortex in the stroke brain. Using subventricular neurosphere and matrigel cultures, we demonstrated that proliferation and migration of SVZ neuroprogenitor cells were enhanced by 9cRA. Our data support a delayed and non-invasive drug therapy for stroke. Intranasal 9cRA can facilitate the functional recovery and endogenous repair in the ischemic brain.

Original language	English
Article number	4512
Journal	Scientific Reports
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41598-017-04048-2
Publication status	Published - Dec 1 2017

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title = "9-cis retinoic acid induces neurorepair in stroke brain",

abstract = "The purpose of this study was to examine the neurorestorative effect of delayed 9 cis retinoic acid (9cRA) treatment for stroke. Adult male rats received a 90-min right distal middle cerebral artery occlusion (dMCAo). Animals were separated into two groups with similar infarction sizes, based on magnetic resonance imaging on day 2 after dMCAo. 9cRA or vehicle was given via an intranasal route daily starting from day 3. Stroke rats receiving 9cRA post-treatment showed an increase in brain 9cRA levels and greater recovery in motor function. 9cRA enhanced the proliferation of bromodeoxyuridine (+) cells in the subventricular zone (SVZ) and lesioned cortex in the stroke brain. Using subventricular neurosphere and matrigel cultures, we demonstrated that proliferation and migration of SVZ neuroprogenitor cells were enhanced by 9cRA. Our data support a delayed and non-invasive drug therapy for stroke. Intranasal 9cRA can facilitate the functional recovery and endogenous repair in the ischemic brain.",

author = "Yu, {Seong Jin} and Mikko Airavaara and Wu, {Kuo Jen} and Harvey, {Brandon K.} and Liu, {H. S.} and Yihong Yang and Alex Zacharek and Jieli Chen and Yun Wang",

note = "Funding Information: This study was supported by the National Health Research Institutes, Central Government S and T grant (106-1901-01-10-02), Taiwan and the National Institute on Drug Abuse, U.S.A. Publisher Copyright: {\textcopyright} 2017 The Author(s).",

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AU - Yu, Seong Jin

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AU - Wu, Kuo Jen

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AU - Liu, H. S.

AU - Yang, Yihong

AU - Zacharek, Alex

AU - Chen, Jieli

AU - Wang, Yun

N1 - Funding Information: This study was supported by the National Health Research Institutes, Central Government S and T grant (106-1901-01-10-02), Taiwan and the National Institute on Drug Abuse, U.S.A. Publisher Copyright: © 2017 The Author(s).

PY - 2017/12/1

Y1 - 2017/12/1

N2 - The purpose of this study was to examine the neurorestorative effect of delayed 9 cis retinoic acid (9cRA) treatment for stroke. Adult male rats received a 90-min right distal middle cerebral artery occlusion (dMCAo). Animals were separated into two groups with similar infarction sizes, based on magnetic resonance imaging on day 2 after dMCAo. 9cRA or vehicle was given via an intranasal route daily starting from day 3. Stroke rats receiving 9cRA post-treatment showed an increase in brain 9cRA levels and greater recovery in motor function. 9cRA enhanced the proliferation of bromodeoxyuridine (+) cells in the subventricular zone (SVZ) and lesioned cortex in the stroke brain. Using subventricular neurosphere and matrigel cultures, we demonstrated that proliferation and migration of SVZ neuroprogenitor cells were enhanced by 9cRA. Our data support a delayed and non-invasive drug therapy for stroke. Intranasal 9cRA can facilitate the functional recovery and endogenous repair in the ischemic brain.

AB - The purpose of this study was to examine the neurorestorative effect of delayed 9 cis retinoic acid (9cRA) treatment for stroke. Adult male rats received a 90-min right distal middle cerebral artery occlusion (dMCAo). Animals were separated into two groups with similar infarction sizes, based on magnetic resonance imaging on day 2 after dMCAo. 9cRA or vehicle was given via an intranasal route daily starting from day 3. Stroke rats receiving 9cRA post-treatment showed an increase in brain 9cRA levels and greater recovery in motor function. 9cRA enhanced the proliferation of bromodeoxyuridine (+) cells in the subventricular zone (SVZ) and lesioned cortex in the stroke brain. Using subventricular neurosphere and matrigel cultures, we demonstrated that proliferation and migration of SVZ neuroprogenitor cells were enhanced by 9cRA. Our data support a delayed and non-invasive drug therapy for stroke. Intranasal 9cRA can facilitate the functional recovery and endogenous repair in the ischemic brain.

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9-cis retinoic acid induces neurorepair in stroke brain

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