7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents

Jang Yang Chang; Hsing Pang Hsieh; Chi Yen Chang; Kuo Shun Hsu; Yi Fang Chiang; Chi Ming Chen; Ching Chuan Kuo; Jing Ping Liou

doi:10.1021/jm061076u

7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents

Jang Yang Chang, Hsing Pang Hsieh, Chi Yen Chang, Kuo Shun Hsu, Yi Fang Chiang, Chi Ming Chen, Ching Chuan Kuo, Jing Ping Liou

Research output: Contribution to journal › Article › peer-review

75 Citations (Scopus)

Abstract

A novel series of 7-aroyl-aminoindoline-1-benzenesulfonamides showed excellent activity as inhibitors of tubulin polymerization through binding with the colchicine binding site of microtubules. Compound 15 and 16 display IC ₅₀ values of 1.1 and 1.2 μM, respectively. Compound 15 inhibited the human cancer cell growth of KB, MKN45, H460, HT29, and TSGH, as well as one human-resistant cancer line of KB-vin 10, with an IC₅₀ of 9.6, 8.8, 9.4, 8.6, 10.8, and 8.9 nM, respectively.

Original language	English
Pages (from-to)	6656-6659
Number of pages	4
Journal	Journal of Medicinal Chemistry
Volume	49
Issue number	23
DOIs	https://doi.org/10.1021/jm061076u
Publication status	Published - Nov 16 2006

ASJC Scopus subject areas

Organic Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/jm061076u

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title = "7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents",

abstract = "A novel series of 7-aroyl-aminoindoline-1-benzenesulfonamides showed excellent activity as inhibitors of tubulin polymerization through binding with the colchicine binding site of microtubules. Compound 15 and 16 display IC 50 values of 1.1 and 1.2 μM, respectively. Compound 15 inhibited the human cancer cell growth of KB, MKN45, H460, HT29, and TSGH, as well as one human-resistant cancer line of KB-vin 10, with an IC50 of 9.6, 8.8, 9.4, 8.6, 10.8, and 8.9 nM, respectively.",

author = "Chang, {Jang Yang} and Hsieh, {Hsing Pang} and Chang, {Chi Yen} and Hsu, {Kuo Shun} and Chiang, {Yi Fang} and Chen, {Chi Ming} and Kuo, {Ching Chuan} and Liou, {Jing Ping}",

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doi = "10.1021/jm061076u",

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T1 - 7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents

AU - Chang, Jang Yang

AU - Hsieh, Hsing Pang

AU - Chang, Chi Yen

AU - Hsu, Kuo Shun

AU - Chiang, Yi Fang

AU - Chen, Chi Ming

AU - Kuo, Ching Chuan

AU - Liou, Jing Ping

PY - 2006/11/16

Y1 - 2006/11/16

N2 - A novel series of 7-aroyl-aminoindoline-1-benzenesulfonamides showed excellent activity as inhibitors of tubulin polymerization through binding with the colchicine binding site of microtubules. Compound 15 and 16 display IC 50 values of 1.1 and 1.2 μM, respectively. Compound 15 inhibited the human cancer cell growth of KB, MKN45, H460, HT29, and TSGH, as well as one human-resistant cancer line of KB-vin 10, with an IC50 of 9.6, 8.8, 9.4, 8.6, 10.8, and 8.9 nM, respectively.

AB - A novel series of 7-aroyl-aminoindoline-1-benzenesulfonamides showed excellent activity as inhibitors of tubulin polymerization through binding with the colchicine binding site of microtubules. Compound 15 and 16 display IC 50 values of 1.1 and 1.2 μM, respectively. Compound 15 inhibited the human cancer cell growth of KB, MKN45, H460, HT29, and TSGH, as well as one human-resistant cancer line of KB-vin 10, with an IC50 of 9.6, 8.8, 9.4, 8.6, 10.8, and 8.9 nM, respectively.

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7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents

Abstract

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UN SDGs

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