3D scaffold with PCL combined biomedical ceramic materials for bone tissue regeneration

Ming Jyh Chern; Liang Yo Yang; Yung Kang Shen; Jia Hsiang Hung

doi:10.1007/s12541-013-0298-1

3D scaffold with PCL combined biomedical ceramic materials for bone tissue regeneration

Ming Jyh Chern, Liang Yo Yang, Yung Kang Shen, Jia Hsiang Hung

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Three-dimensional porous biodegradable polymer scaffolds have been widely used for tissue engineering of bone repair or regeneration. The primary function of scaffolds is to provide structure support for the cells adhesion and proliferation. This study selects the Poly-e{open}-caprolactone (PCL) as material, NaCl mixed with hydroxyapatite (HA) or nano-aluminum oxide (nAl₂O₃) for porous scaffold. This study uses the solvent casting/particulate leaching method to fabricate the porous scaffold. The authors discuss the compression mechanical properties, physical properties (porosity, moisture content, contact angle) of a pure PCL, PCL/mHA, PCL/nHA and PCL/nAl₂O₃ scaffolds. In vitro cell culture is used for osteoblast cell (MG63) and the microculture tetrazolium test (MTT) is undertaken in the scaffold. The scaffolds are implanted to the femur of rats and histological examination is attempted after 2 weeks. The experimental results indicate that HA and nAl₂O₃ can improve the hydrophilic property. In conclusion, the PCL/nHA scaffold exhibits splendid in vivo biocompatibility and osteogenesis.

Original language	English
Pages (from-to)	2201-2207
Number of pages	7
Journal	International Journal of Precision Engineering and Manufacturing
Volume	14
Issue number	12
DOIs	https://doi.org/10.1007/s12541-013-0298-1
Publication status	Published - Dec 2013

Keywords

In vitro/In vivo
Mechanical properties
Porosity/Voids
Scanning electron microscopy (SEM)

ASJC Scopus subject areas

Mechanical Engineering
Industrial and Manufacturing Engineering
Electrical and Electronic Engineering

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10.1007/s12541-013-0298-1

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title = "3D scaffold with PCL combined biomedical ceramic materials for bone tissue regeneration",

abstract = "Three-dimensional porous biodegradable polymer scaffolds have been widely used for tissue engineering of bone repair or regeneration. The primary function of scaffolds is to provide structure support for the cells adhesion and proliferation. This study selects the Poly-e\{open\}-caprolactone (PCL) as material, NaCl mixed with hydroxyapatite (HA) or nano-aluminum oxide (nAl2O3) for porous scaffold. This study uses the solvent casting/particulate leaching method to fabricate the porous scaffold. The authors discuss the compression mechanical properties, physical properties (porosity, moisture content, contact angle) of a pure PCL, PCL/mHA, PCL/nHA and PCL/nAl2O3 scaffolds. In vitro cell culture is used for osteoblast cell (MG63) and the microculture tetrazolium test (MTT) is undertaken in the scaffold. The scaffolds are implanted to the femur of rats and histological examination is attempted after 2 weeks. The experimental results indicate that HA and nAl2O3 can improve the hydrophilic property. In conclusion, the PCL/nHA scaffold exhibits splendid in vivo biocompatibility and osteogenesis.",

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author = "Chern, \{Ming Jyh\} and Yang, \{Liang Yo\} and Shen, \{Yung Kang\} and Hung, \{Jia Hsiang\}",

note = "Funding Information: This work was supported by Taipei Medical University and National Taiwan University of Science and Technology. We also gratefully acknowledge the financial support from Taipei Medical University under contract TMU-NTUST-100-06. This research was also supported by Grant NSC 100-2314-B-038-011 (LYY) and Department of Health Grant DOH99-TD-B-111-003, Center of Excellence for Clinical Trial and Research in Neuroscience.",

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AU - Chern, Ming Jyh

AU - Yang, Liang Yo

AU - Shen, Yung Kang

AU - Hung, Jia Hsiang

N1 - Funding Information: This work was supported by Taipei Medical University and National Taiwan University of Science and Technology. We also gratefully acknowledge the financial support from Taipei Medical University under contract TMU-NTUST-100-06. This research was also supported by Grant NSC 100-2314-B-038-011 (LYY) and Department of Health Grant DOH99-TD-B-111-003, Center of Excellence for Clinical Trial and Research in Neuroscience.

PY - 2013/12

Y1 - 2013/12

N2 - Three-dimensional porous biodegradable polymer scaffolds have been widely used for tissue engineering of bone repair or regeneration. The primary function of scaffolds is to provide structure support for the cells adhesion and proliferation. This study selects the Poly-e{open}-caprolactone (PCL) as material, NaCl mixed with hydroxyapatite (HA) or nano-aluminum oxide (nAl2O3) for porous scaffold. This study uses the solvent casting/particulate leaching method to fabricate the porous scaffold. The authors discuss the compression mechanical properties, physical properties (porosity, moisture content, contact angle) of a pure PCL, PCL/mHA, PCL/nHA and PCL/nAl2O3 scaffolds. In vitro cell culture is used for osteoblast cell (MG63) and the microculture tetrazolium test (MTT) is undertaken in the scaffold. The scaffolds are implanted to the femur of rats and histological examination is attempted after 2 weeks. The experimental results indicate that HA and nAl2O3 can improve the hydrophilic property. In conclusion, the PCL/nHA scaffold exhibits splendid in vivo biocompatibility and osteogenesis.

AB - Three-dimensional porous biodegradable polymer scaffolds have been widely used for tissue engineering of bone repair or regeneration. The primary function of scaffolds is to provide structure support for the cells adhesion and proliferation. This study selects the Poly-e{open}-caprolactone (PCL) as material, NaCl mixed with hydroxyapatite (HA) or nano-aluminum oxide (nAl2O3) for porous scaffold. This study uses the solvent casting/particulate leaching method to fabricate the porous scaffold. The authors discuss the compression mechanical properties, physical properties (porosity, moisture content, contact angle) of a pure PCL, PCL/mHA, PCL/nHA and PCL/nAl2O3 scaffolds. In vitro cell culture is used for osteoblast cell (MG63) and the microculture tetrazolium test (MTT) is undertaken in the scaffold. The scaffolds are implanted to the femur of rats and histological examination is attempted after 2 weeks. The experimental results indicate that HA and nAl2O3 can improve the hydrophilic property. In conclusion, the PCL/nHA scaffold exhibits splendid in vivo biocompatibility and osteogenesis.

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KW - Mechanical properties

KW - Porosity/Voids

KW - Scanning electron microscopy (SEM)

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3D scaffold with PCL combined biomedical ceramic materials for bone tissue regeneration

Abstract

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