3D-Printable Photothermal and Temperature-Controlled Polycaprolactone Scaffolds Incorporating Gold Plasmonic Blackbodies for Bone Tissue Engineering

Chieh Ying Chen; Ruaina Lily Hope Gadia Moreno; Po Yao Wang; Thanh Sang Nguyen; Jia Lin Wu; Kuan Hao Chen; Chih Hwa Chen; Chia Ying Lin; Pei Chun Wong

doi:10.1021/acsami.5c05707

3D-Printable Photothermal and Temperature-Controlled Polycaprolactone Scaffolds Incorporating Gold Plasmonic Blackbodies for Bone Tissue Engineering

Chieh Ying Chen, Ruaina Lily Hope Gadia Moreno, Po Yao Wang, Thanh Sang Nguyen, Jia Lin Wu, Kuan Hao Chen, Chih Hwa Chen, Chia Ying Lin, Pei Chun Wong

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Three-dimensional (3D) printing technology has revolutionized the design and fabrication of bone scaffolds, offering precise and customizable solutions for bone tissue engineering. In this study, we developed polycaprolactone (PCL) scaffolds that incorporated gold plasmonic blackbodies (AuPBs) to harness photothermal properties for temperature-controlled bone regeneration. The AuPB-PCL scaffolds demonstrated enhanced mechanical strength, a tunable thermal response under near-infrared (NIR) laser irradiation, and improved osteogenic potential. Photothermal stimulation effectively modulated cellular responses, promoting osteoblast proliferation, alkaline phosphatase (ALP) activity, and mineralization. Notably, mild hyperthermia (39-41 °C) induced by laser irradiation optimized osteogenesis, while excessive temperatures (≥42.5 °C) impaired cellular function due to mitochondrial stress and oxidative damage. These findings highlight the potential of AuPB-PCL scaffolds for controlled photothermal bone regeneration, offering a promising strategy for precise, completely noninvasive stimulation of bone repair.

Original language	English
Pages (from-to)	29455-29468
Number of pages	14
Journal	ACS Applied Materials and Interfaces
Volume	17
Issue number	20
DOIs	https://doi.org/10.1021/acsami.5c05707
Publication status	Published - May 21 2025

Keywords

3D printing
gold plasmonic blackbody
NIR laser irradiation
photothermal effect
polycaprolactone

ASJC Scopus subject areas

General Materials Science

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10.1021/acsami.5c05707

Cite this

Chen, C. Y., Hope Gadia Moreno, R. L., Wang, P. Y., Nguyen, T. S., Wu, J. L., Chen, K. H., Chen, C. H., Lin, C. Y., & Wong, P. C. (2025). 3D-Printable Photothermal and Temperature-Controlled Polycaprolactone Scaffolds Incorporating Gold Plasmonic Blackbodies for Bone Tissue Engineering. ACS Applied Materials and Interfaces, 17(20), 29455-29468. https://doi.org/10.1021/acsami.5c05707

3D-Printable Photothermal and Temperature-Controlled Polycaprolactone Scaffolds Incorporating Gold Plasmonic Blackbodies for Bone Tissue Engineering. / Chen, Chieh Ying; Hope Gadia Moreno, Ruaina Lily; Wang, Po Yao et al.
In: ACS Applied Materials and Interfaces, Vol. 17, No. 20, 21.05.2025, p. 29455-29468.

Research output: Contribution to journal › Article › peer-review

Chen, CY, Hope Gadia Moreno, RL, Wang, PY, Nguyen, TS, Wu, JL , Chen, KH , Chen, CH, Lin, CY & Wong, PC 2025, '3D-Printable Photothermal and Temperature-Controlled Polycaprolactone Scaffolds Incorporating Gold Plasmonic Blackbodies for Bone Tissue Engineering', ACS Applied Materials and Interfaces, vol. 17, no. 20, pp. 29455-29468. https://doi.org/10.1021/acsami.5c05707

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abstract = "Three-dimensional (3D) printing technology has revolutionized the design and fabrication of bone scaffolds, offering precise and customizable solutions for bone tissue engineering. In this study, we developed polycaprolactone (PCL) scaffolds that incorporated gold plasmonic blackbodies (AuPBs) to harness photothermal properties for temperature-controlled bone regeneration. The AuPB-PCL scaffolds demonstrated enhanced mechanical strength, a tunable thermal response under near-infrared (NIR) laser irradiation, and improved osteogenic potential. Photothermal stimulation effectively modulated cellular responses, promoting osteoblast proliferation, alkaline phosphatase (ALP) activity, and mineralization. Notably, mild hyperthermia (39-41 °C) induced by laser irradiation optimized osteogenesis, while excessive temperatures (≥42.5 °C) impaired cellular function due to mitochondrial stress and oxidative damage. These findings highlight the potential of AuPB-PCL scaffolds for controlled photothermal bone regeneration, offering a promising strategy for precise, completely noninvasive stimulation of bone repair.",

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3D-Printable Photothermal and Temperature-Controlled Polycaprolactone Scaffolds Incorporating Gold Plasmonic Blackbodies for Bone Tissue Engineering

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