15‐Hydroxyprostaglandin Dehydrogenase Activity in the Lower Genitourinary Tract A Preliminary Report

C. C. CHANG; S. N. LIN; F. S. CHEN; W. C. CHANG

doi:10.1111/j.1464-410X.1991.tb15418.x

15‐Hydroxyprostaglandin Dehydrogenase Activity in the Lower Genitourinary Tract A Preliminary Report

C. C. CHANG, S. N. LIN, F. S. CHEN, W. C. CHANG

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Summary— In the pathway of prostaglandin inactivation, 15‐hydroxyprostaglandin dehydrogenase (15‐OHPGDH) has been proven to be the catalyst of the primary catabolic step in the oxidation of the 15‐hydroxyl group into a 15‐keto moiety in most derivatives of prostaglandins. In this study, we analysed 15‐OHPGDH activity in the lower genitourinary tract. The specimens were obtained with permission from patients who underwent surgery. These specimens were then sent for quantitative determination using a tritium release assay specific for 15‐OHPGDH. The highest enzyme activity was found in the ureter with a mean ± SE (pmol/min/mg) of 94.99 ± 51.00; the lowest activity was in the vas deferens, with a value of 0.18 ± 0.21. This preliminary study indicated that the activity of 15‐OHPGDH in the lower genitourinary tract was significant and that prostaglandin levels in the genitourinary tract may be regulated by this enzyme.

Original language	English
Pages (from-to)	579-581
Number of pages	3
Journal	British Journal of Urology
Volume	68
Issue number	6
DOIs	https://doi.org/10.1111/j.1464-410X.1991.tb15418.x
Publication status	Published - Dec 1991
Externally published	Yes

ASJC Scopus subject areas

Urology

Access to Document

10.1111/j.1464-410X.1991.tb15418.x

Cite this

@article{ba6d89f0d5f14503a7d20277e6d4c893,

title = "15‐Hydroxyprostaglandin Dehydrogenase Activity in the Lower Genitourinary Tract A Preliminary Report",

abstract = "Summary— In the pathway of prostaglandin inactivation, 15‐hydroxyprostaglandin dehydrogenase (15‐OHPGDH) has been proven to be the catalyst of the primary catabolic step in the oxidation of the 15‐hydroxyl group into a 15‐keto moiety in most derivatives of prostaglandins. In this study, we analysed 15‐OHPGDH activity in the lower genitourinary tract. The specimens were obtained with permission from patients who underwent surgery. These specimens were then sent for quantitative determination using a tritium release assay specific for 15‐OHPGDH. The highest enzyme activity was found in the ureter with a mean ± SE (pmol/min/mg) of 94.99 ± 51.00; the lowest activity was in the vas deferens, with a value of 0.18 ± 0.21. This preliminary study indicated that the activity of 15‐OHPGDH in the lower genitourinary tract was significant and that prostaglandin levels in the genitourinary tract may be regulated by this enzyme.",

author = "CHANG, {C. C.} and LIN, {S. N.} and CHEN, {F. S.} and CHANG, {W. C.}",

year = "1991",

month = dec,

doi = "10.1111/j.1464-410X.1991.tb15418.x",

language = "English",

volume = "68",

pages = "579--581",

journal = "British Journal of Urology",

issn = "1464-4096",

publisher = "Wiley-Blackwell",

number = "6",

}

TY - JOUR

T1 - 15‐Hydroxyprostaglandin Dehydrogenase Activity in the Lower Genitourinary Tract A Preliminary Report

AU - CHANG, C. C.

AU - LIN, S. N.

AU - CHEN, F. S.

AU - CHANG, W. C.

PY - 1991/12

Y1 - 1991/12

N2 - Summary— In the pathway of prostaglandin inactivation, 15‐hydroxyprostaglandin dehydrogenase (15‐OHPGDH) has been proven to be the catalyst of the primary catabolic step in the oxidation of the 15‐hydroxyl group into a 15‐keto moiety in most derivatives of prostaglandins. In this study, we analysed 15‐OHPGDH activity in the lower genitourinary tract. The specimens were obtained with permission from patients who underwent surgery. These specimens were then sent for quantitative determination using a tritium release assay specific for 15‐OHPGDH. The highest enzyme activity was found in the ureter with a mean ± SE (pmol/min/mg) of 94.99 ± 51.00; the lowest activity was in the vas deferens, with a value of 0.18 ± 0.21. This preliminary study indicated that the activity of 15‐OHPGDH in the lower genitourinary tract was significant and that prostaglandin levels in the genitourinary tract may be regulated by this enzyme.

AB - Summary— In the pathway of prostaglandin inactivation, 15‐hydroxyprostaglandin dehydrogenase (15‐OHPGDH) has been proven to be the catalyst of the primary catabolic step in the oxidation of the 15‐hydroxyl group into a 15‐keto moiety in most derivatives of prostaglandins. In this study, we analysed 15‐OHPGDH activity in the lower genitourinary tract. The specimens were obtained with permission from patients who underwent surgery. These specimens were then sent for quantitative determination using a tritium release assay specific for 15‐OHPGDH. The highest enzyme activity was found in the ureter with a mean ± SE (pmol/min/mg) of 94.99 ± 51.00; the lowest activity was in the vas deferens, with a value of 0.18 ± 0.21. This preliminary study indicated that the activity of 15‐OHPGDH in the lower genitourinary tract was significant and that prostaglandin levels in the genitourinary tract may be regulated by this enzyme.

UR - http://www.scopus.com/inward/record.url?scp=0025885502&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025885502&partnerID=8YFLogxK

U2 - 10.1111/j.1464-410X.1991.tb15418.x

DO - 10.1111/j.1464-410X.1991.tb15418.x

M3 - Article

C2 - 1773286

AN - SCOPUS:0025885502

SN - 1464-4096

VL - 68

SP - 579

EP - 581

JO - British Journal of Urology

JF - British Journal of Urology

IS - 6

ER -

15‐Hydroxyprostaglandin Dehydrogenase Activity in the Lower Genitourinary Tract A Preliminary Report

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this