紅麴粉末對倉鼠體內CoQ10、維生素E及低密度脂蛋白脂肪酸的影響

The aim of this study was to assess the effect of the Monascus rice powder on coenzyme Q₁₀ (CoQ₁₀), vitamin E, and plasma low-density lipoprotein (LDL) fatty acid profiles in male hamsters. Seventytwo male hamsters (110 g) were divided into six treatment groups (C, control diet; L, low-dose 0.5% Monascus rice powder diet; H, high-dose 4% Monascus rice powder diet; CE, LE, and HE, are the C, L, and H group each with the addition of 0.3% vitamin E). After a 4-week experimental period, blood and liver samples were taken for cholesterol, triglycerides, malondialdehyde (MDA), vitamin E, and CoQ₁₀ analysis. Results indicated that Monascus rice powder could significantly lower plasma cholesterol level, the LDL-C/HDL-C ratio, and plasma triglyceride, hepatic total cholesterol, and triglyceride levels. In addition, Monascus rice powder also decreased both the linoleic acid/arachidonic acid and PUFA/MUFA ratios in the low-ensity lipoprotein. However, Monascus rice powder reduced the plasma vitamin E content, the vitamin E/LDL-C ratio but hepatic vitamin E significantly increased. Vitamin E but not Monascus rice powder inhibited hepatic MDA production. The content of hamster hepatic CoQ₁₀ significantly decreased with Monascus rice powder, whereas the CoQ₁₀/cholesterol ratio increased. In summary, the antioxidative effect of Monascus rice powder was affected by many factors. Monascus rice powder not only decreased the hepatic levels of CoQ₁₀ and vitamin E but decreased the cholesterol content simultaneously, with the result that it had no effect on antioxidative activity.