糙薏仁對餵與高脂高膽固醇飲食倉鼠血液脂質及肝臟損傷指標的影響

Consumption of high fat and high cholesterol diet is always associated with hyperlipidemia, increased hepatic lipid accumulation, oxidative stress, and liver injury. Dehulled adlay (DA) is one of the staple foods consumed by Taiwanese people. This study is aimed at investigating the effects of DA on hyperlipidemia, hepatic lipid accumulation and injury in animals fed with a high-fat high-cholesterol diet (HFHCD). Male Syrian hamsters were randomly assigned into 5 groups and fed with different diets, control, HFHCD, HFHCD with 10, 20, and 40% freezed-dried DA, for 8 weeks. The animals were sacrificed, and blood, liver, and fecal samples were collected for analysis. The results showed that 20 and 40% DA significantly reduced serum total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) and malondialdehyde (MDA) induced by HFHCD, and such effects were associated with decreased atherogenic coefficient (AC). Besides, reduction of hepatic injury markers, aspartate aminotransferase (AST), alanine aminotransferase (ALT), matrix metalloproteinase (MMP)-2, and MMP-9 activities were also observed in 20 and 40% DA groups, although hepatic TC accumulation was increased. In conclusion, 20 and 40% DA has protective effects on hyperlipidemia and hepatic injury by decreasing serum TC, LDL-C, AST, ALT concentrations, and hepatic MMP-2 and MMP-9 activities in hamster fed with a HFHCD.