糖尿病患者血液中三價鉻與葡萄糖及脂質濃度之相關性

This study investigated the correlation between blood chromium (III) concentrations n normal, mild hyperglycemia and severe hyperglycemia for hemoglobin A1c (HbA1c), serum insulin and serum lipid concentrations. Eighty-four elderly subjects (aged 40~70 years; 41 male and 43 female) were divided into three groups: severe hyperglycemia group (fasting glucose ＞ 8.3 mol/L, n = 38), mild hyperglycemia group (fasting glucose = 7.0~8.3 mol/L, n = 24) and normal group (fasting glucose ＜ 7.0 mol/L, n = 24). The fasting glucose, postprandial glucose and hemoglobin A1c concentrations were higher ( p ＜ 0.05) in the mild hyperglycemia group and severe hyperglycemia group than the normal group. The blood chromium (III) concentration was lower ( p ＜ 0.05) in the severe hyperglycemia group and mild hyperglycemia group than the normal group. Triglyceride concentration, ratios of total cholesterol to HDL-cholesterol and LDL-cholesterol to HDL-cholesterol were higher in the severe hyperglycemia group and mild hyperglycemia group than the normal group. There was s significant negative correlation (r = -0.9931; -0.9529) between blood chromium level and fasting glucose or fasting insulin concentration. There was a significant negative correlation (r = -0.8504; -0.9894) between blood chromium level and LDL-cholesterol or triglyceride concentration. These results suggest that the blood chromium (III) concentration decreased with increasing blood glucose concentration and serum lipids in diabetes.