第一期下期與第二期上期之子宮頸癌經不同治療模式後的長期生活品質比較

Purpose: To compare the difference treatment modalities for complications and long-term quality of life (QoL) in patients with stage IB and stage IIA uterine cervical carcinoma.Materials and Methods: Three hundred and thirty-six patients of two institutions were invited to participate in this study. Inclusive patients were follow-up at least 2 years after the completion of the treatment (follow-up periods: 25-218 months) and were between ages 45-74 years. According to the treatment modalities, they were divided into 3 groups: surgery (OP), radiation therapy (RT), and surgery with postoperative radiation therapy (OP+RT). All patients were asked to complete the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire (QLQ C-30) and complications Questionnaire for the assessment of QoL.Results: Total 8 items of complicatons were statistically significant, including abdominal pain, diarrhea, constipation, blood stools, dysuria, urine incontience, edema of lower extremities and hot flush. Constipation, dysuria, and hot flush were statistically higher in OP group; diarrhea and blood stools were highter in RT group. Significant higher complications treated by OP+RT were: diarrhea, blood stools, urine incontience and edema of lower extremities. Comparison of EORTC QLQ-C30, the majority of items showed little difference among these three treatment modalities, except cognitive functioning and social functioning in functional scales and fatique, nausea/vomiting, poor appetite, constipation and economical difficult in symptoms scales.Conclusion: Our study revealed the different complications in stage IB and Stage IIA uterine cervical cancer patients treated by different modalities, whereas long-term QoL seem little difference among these three different modalities. These data were helpful for clinical physician not only for selecting treatment modalities when concerning with QoL changes of the patients, but also for rehabilitation and supportive care of the patients after treatment.