大蒜粉末對倉鼠降血脂作用及其體內抗氧化狀態之影響

The purpose of the study was to evaluate the effectiveness of garlic powder on lipid metabolism and the activities of antioxidative enzymes while treated with various lipids containing diet in hamsters. Thirty eight-week old hamsters were divided into five groups and fed with 15% dietary lipids and 0.1% cholesterol containing diet. The control group (S group) was given soy oil without garlic powder, other groups were added 3% garlic powder and various lipids such as soy oil (SG group), lard (LG group), fish oil (FG group) and canola oil (CG group). After 6 weeks, the animals were scarified. The lipids profile of plasma, livers and feces and the serum antioxidative status were also determined. Comparing each garlic subgroup, the LG group had the highest plasma total cholesterol, phospholipid, total lipids, low density lipoprotein-cholesterol (LDL-C), TG, very low density lipoprotein- triglyceride (VLDL-TG), LDL-TG and liver total lipids than other groups (P <0.05), but no significantly differences with S group. The LG group, SG group and CG group showed the higher liver total cholesterol than the FG group (P <0.05). The activities of plasma glutamateoxaloacetate transaminase (GOT) and glutamate-pyruvate transaminase (GPT) showed no significantly differences. All garlic groups exhibited an increase in the excretion of total bile acids in feces, and an inhibition in the accumulation of total cholesterol, phospholipids, and triglycerides (TG) in liver as compared to the control group. Hamsters consumed garlic powder showed higher plasma total antioxidative status (TAS), less activities of plasma glutamic-pyruvic transaminase (GPT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and lower liver lipid peroxides (TBARS). Garlic powder affected the lipid metabolism and antioxidative status while hamster fed with various lipids-containing diets. Garlic powder consumption may decrease the accumulation of lipids in liver, increase the excretion of total bile acids in feces, and higher the antioxidative capacity while hamsters fed with various lipids-containing diets.