人類血小板抗原之基因多型性及第五凝血因子Leiden 在臺灣華人缺血性腦 中風之危險因子

Objective: Polymorphisms of human platelet antigens (HPA) have been considered to be independent risk factors for myocardial infarction and ischemic stroke. In addition, in the coagulation factor V gene (factor V Leiden), which results in activated protein C resistance, is also associated with increased risk of deep vein thrombosis or ischemic stroke. This study investigated the association polymorphism in HPA and factor V Leiden and the development of vascular diseases in Taiwanese ischemic stroke patients. Methods: A total of 67 patients with ischemic stroke and 149 healthy controls were recruited for participation in this study. The genetic polymorphisms of HPA and factor V Leiden were determined by polymerase chain reaction-restriction fragment length polymorphism. Results: We found difference in polymophisms of HPA between patients with ischemic stroke and controls. No factor V Leiden was found in patients or controls. These suggest that there is no V Leiden in Taiwanese population. Conclusions: We conclude that polymorphisms of HPAs and factor V Leiden are not the genetic risk factor ischemic stroke among Taiwanese.