To Explore the Mechanism and Precise Therapy of the Novel Copper Death Mtf1/Lias Axis in the Treatment of Intervertebral Disc Degeneration

Project: A - Government Institutionb - National Science and Technology Council

Project Details

Description

Cuproptosis是一種以磷脂過氧化為標誌的銅依賴性程式性細胞死亡,受複雜的細 胞代謝途徑調節,包括脂質代謝、銅平衡、氧化還原穩態和線粒體活性。銅死亡在調節椎間盤退化(IVDD)中的作用是一個重要的研究課題。本計劃將釐清新穎性銅死亡MTF1/LIAS訊號軸與椎間盤退化的關係,以及在髓核、纖維環細胞中的調控網路,為椎間盤退化的精準治療發展提供參考。
StatusFinished
Effective start/end date8/1/237/31/24

Keywords

  • intervertebral disc degeneration
  • matrix metalloproteinases
  • cuproptosis
  • oxidative stress
  • MTF1/LIAS axis