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The Use of Mass Spectrometry Strategy for Effects of Dietary and Exercise Models on Progression of Nonalcoholic Fatty Liver Disease in Morbidly Obese Rats Undergoing Bariatric Surgery

Project: A - Government Institution › b - National Science and Technology Council

Project Details

Description

模擬罹患NAFLD之病態性肥胖患者經由手術、飲食及運動介入後對其血液與肝臟病理(發炎與纖維化因子)與脂質代謝之影響。 一、監測病態性肥胖大鼠於不同時間點的血液與肝臟中脂質代謝酵素與代謝物之組態，以了解減重手術、飲食及運動介入的成效。 二、以質譜分析策略(脂質體與代謝體)解析肝臟與血液脂質代謝組態，並嘗試了解飲食與運動介入階段中，檢測各時間點肝臟與血液中脂質代謝相關產物是否具備發展成為預測NAFLD病理狀態的前期指標。
StatusFinished
Effective start/end date8/1/23 → 7/31/25

Keywords

  • Nonalcoholic fatty liver disease
  • Bariatric surgery
  • Diet and exercise intervention
  • lipidomes and metabolites

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