The Effects of Glyoxalase 1 Gene Manipulation on Metabolic Stress-Mediated Lung Cancer Cell Epithelial-Mesenchymal Transition and Metastasis in Malignant Pleural Effusion

Project: A - Government Institution › b - National Science and Technology Council

Project Details

Description

惡性肋膜積水為肺癌晚期表現且預後不佳，本研究發現惡性肋膜積水中MG含量偏高，且可誘發肺癌細胞轉移，而過量表現GLO1則可減少MG並抑制腫瘤轉移。因此開發具GLO1激活功效的藥物，或許可以改善肺癌合併惡性肋膜積水病人的預後。
StatusFinished
Effective start/end date8/1/22 → 7/31/23

Keywords

  • malignant pleural effusion
  • lung adenocarcinoma
  • epithelial-mesenchymal transition
  • metastasis
  • methylglyoxal
  • glycative stress
  • dicarbonyl
  • glyoxalase 1

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