Project Details
Description
Studies have demonstrated that immediate muscle endurance training enhances brain-derived neurotrophic factor (BDNF), therefore, it is more consistent. However, the effects of high-intensity circuit training that has both time efficiency and multiple fitness benefits on BDNF and cognitive in the elderly are unknown. On the other hand, whether the two trainings are affected by the BDNF Val66Met polymorphism remains to be clarified. The purpose of this study at the first year is to observe the changes of serum BDNF concentration and cognitive function (global cognitive and executive function) in the elderly with different BDNF Val66Met genotypes after single resistance exercise (RT), high-intensity circuit training (HICT) and stretching control (SC) intervention. In the second year, the focus is to understand the effects of an 8-week interventional RT, HICT and SC on serum BDNF concentration, cognitive function and physical performance (balance, muscle fitness and aerobic capacity) in the elderly with different BDNF Val66Met genotypes. The method of the research in the first year will encompass the recruitment of ninety elders with different BDNF Val66Met genotypes to undertake RT, HICT and SC with a counterbalanced order to examine the change of serum BDNF concentration; pre and immediate post cognitive function, and a 24-hour post-exercise. In the second year, ninety elders will be recruited with different BDNF Val66Met genotypes, thus all participants will be randomly assigned into groups- RT-Met-, RT-Met+, HICT -Met-, HICT -Met+, SC -Met-, SC -Met+. Each group will be assigned to do the training 3 times per week for a 8-week period and all the participants will be evaluated based on serum BDNF concentration, cognitive function and physical performance before, fourth week and after the training. Data will be analyzed using two-way ANOVA. This study expects to understand the response of traditional resistance exercise and high-intensity circuit training of neurotrophic factors and cognition in the elderly with BDNF gene polymorphisms. Thus, the research results may provide a reference for exercise prescriptions for fall prevention, to strengthen the brain and healthy aging in the elderly.
Status | Finished |
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Effective start/end date | 8/1/20 → 7/31/21 |
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