The Association between the Gene Polymorphisms and Plasma Concentration of Tissue Inhibitors of Metalloproteinase 3, Total Urinary Arsenic Concentration, Red Blood Cell Cadmium and Lead Levels, and Plasma Selenium Concentration and Chronic Kidney Disease

預期能建立與評估血漿金屬蛋白酶組織抑制劑3濃度、TIMP3 rs2234921與TIMP3 rs9619311基因型或單倍型、總尿液砷濃度、血漿硒濃度和紅血球鉛與鎘濃度對慢性腎臟病的相關性與交互作用。此研究結果將有助於預防環境汙染物砷、鉛與鎘的暴露、低硒攝取和低血漿TIMP3濃度以及TIMP3高危險基因型所造成之慢性腎臟病的發生與減緩慢性腎臟病的惡化。