Targeting the Meg3/Mir-181a/Egr1 Regulatory Axis Using Fucoidan in the Prevention of Oral Submucous Fibrosis and Its Translational Application

Project: A - Government Institutionb - National Science and Technology Council

Project Details

Description

本研究計畫重點為鑑定出口腔黏膜下纖維化症之關鍵致病途徑及其轉譯應用,將釐清MEG3/miR-181a/Egr1訊號途徑活化可調控肌纖維母細胞而促使口腔黏膜下纖維化致病,並使用褐藻醣膠來有效阻斷此路徑來作為防治口腔黏膜下纖維化症之新穎策略。研究成果將發表於績優SCI國際學術期刊, 並結合張口練習,進行臨床試驗成效,並進一步申請專利或技轉廠商,進行保健產品開發。
StatusFinished
Effective start/end date6/1/225/31/23

Keywords

  • oral submucous fibrosis
  • MEG3
  • miR-181a
  • Egr1
  • fucoidan